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Exosome-mediated transfer of circRNA563 promoting hepatocellular carcinoma by targeting the microRNA148a-3p/metal-regulatory transcription factor-1 pathway被引量：1: 《World Journal of Gastroenterology》2023年第46期6060-6075,共16页Zhuo-Zhen Lyu Meng Li Ming-Yu Yang Mei-Hong Han Zhen Yang; the National Natural Science Foundation of China,No.81972606 and 82271774.; BACKGROUND Mesenchymal stem cells(MSCs)exert anti-oncogenic effects via exosomes containing non-coding RNA(ncRNA),which play important roles in tumor biology.Our preliminary study identified the interaction of the ncR...; 关键词：EXOSOME Cell communication Noncoding RNA Metal-regulatory transcription factor-1 Mesenchymal stem cells

Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma被引量：1: 《World Journal of Gastroenterology》2020年第42期6599-6613,共15页Yuri Cho Min Ji Park Koeun Kim Sun Woong Kim Wonjin Kim Sooyeon Oh Joo Ho Lee; BACKGROUND The Hippo signaling pathway regulates organ size by regulating cell proliferation and apoptosis with terminal effectors including Yes-associated protein-1(YAP-1).Dysregulation in Hippo pathway has been prop...; 关键词：Hepatocellular carcinoma Yes-associated protein-1 C-MYC Reactive oxygen species Unfolded protein response Activating transcription factor-6

Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells被引量：4: 《World Journal of Gastroenterology》2020年第5期499-513,共15页Hong Zheng Jin-Jing Wang Xiao-Rong Yang Yong-Lin Yu; BACKGROUND MicroRNA 34c(miR-34c)has been reported to be associated with malignant types of cancer,however,it remains unknown whether miR-34c is involved in chemoresistance in gastric cancer(GC).AIM To investigate the ...; 关键词：E2F transcription factor 1 MicroRNA 34c Gastric cancer Paclitaxel combined with cisplatin resistance

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation被引量：11: 《World Journal of Gastroenterology》2017年第6期986-998,共13页Li-Jia Bu Han-Qing Yu Lu-Lu Fan Xiao-Qiu Li Fang Wang Jia-Tao Liu Fei Zhong Cong-Jun Zhang Wei Wei Hua Wang Guo-Ping Sun; grants from the National Natural Science Foundation of China,No.81572430 and No.81272739; AIM To clarify the mechanisms involved in the critical endoplasmic reticulum(ER) stress initiating unfolded protein response pathway modified by melatonin.METHODS Hepatoma cells, Hep G2, were cultured in vitro. Flow c...; 关键词：MELATONIN Endoplasmic reticulum stress Activating transcription factor 6 CYCLOOXYGENASE-2 Hepatocellular carcinoma

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities被引量：5: 《World Journal of Gastroenterology》2015年第5期1436-1443,共8页Jean-Noel Freund Isabelle Duluc Jean-Marie Reimund Isabelle Gross Claire Domon-Dell; The homeoprotein encoded by the intestinal-specific Cdx2 gene is a major regulator of gut development and homeostasis,also involved in colon cancer as well as in intestinal-type metaplasias when it is abnormally expre...; 关键词：HOMEOBOX Transcription Signaling DNA repair RNA splicing INTESTINE Development Cancer HOMEOSTASIS

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer被引量：10: 《World Journal of Gastroenterology》2014年第14期3960-3966,共7页Lin-Hai Yan Wei-Yuan Wei Yu-Bo Xie Qiang Xiao; Supported by The National Natural Science Foundation of China,No.81060201;Natural Science Foundation of Guangxi Zhuang Autonomous Region of China,No.2011GXNS-FA018273 and No.2013GXNSFAA019163;the Key Health Science Fund of Guangxi Zhuang Autonomous Region of China,No.1298003-2-6; Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human g...; 关键词：Caudal-related homeobox transcription factor 2 Gastric cancer Intestinal metaplasia Apoptosis Drug resistance

Transcription factor ERG is a specific and sensitive diagnostic marker for hepatic angiosarcoma被引量：11: 《World Journal of Gastroenterology》2014年第13期3672-3679,共8页Zhan-Bo Wang Jing Yuan Wei Chen Li-Xin Wei; AIM: To investigate the expression of ERG, CD34, CD31 (PECAM-1, platelet/endothelial cell adhesion molecule 1) and factor VIII-related antigen (FVIIIRAg) in the diagnosis of hepatic angiosarcoma patients.; 关键词：LIVER ANGIOSARCOMA ERG IMMUNOHISTOCHEMISTRY Diagnosis

Basic transcription factor 3 is involved in gastric cancer development and progression被引量：6: 《World Journal of Gastroenterology》2013年第28期4495-4503,共9页Qi Liu Jian-Ping Zhou Bin Li Zhong-Cheng Huang Hong-Yu Dong Guang-Yi Li Ke Zhou Shao-Lin Nie; Supported by Science and Technology Project of Hunan Province, China, No. 2013FJ3151; AIM: To further analyse cancer involvement of basic transcription factor 3 (BTF3) after detection of its upregulation in gastric tumor samples. METHODS: BTF3 transcription rates in human gastric tumor tissue samples (...; 关键词：Basic TRANSCRIPTION factor 3 GASTRIC cancer Small interfering RNA Proliferation Apoptosis Cell cycle

Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats被引量：20: 《World Journal of Gastroenterology》2010年第21期2657-2663,共7页Wang, Yu-Ping Cheng, Ming-Liang Zhang, Bao-Fang Mu, Mao Wu, Jun; Supported by A grant from Foundation of High Level Talented Specialists of Guizhou Province,China,No. TZJF-200850;a grant from Foundation of the Program for Tackling Key Problems of Guizhou Science and Technology Department,China,No. 2010GZ97666; AIM:To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2(Nrf2) transcription factor in rats.METHODS:Forty-five male Sprague-Dawley rats were randomly divided into control group(A);CCl...; 关键词：BLUEBERRY Hepatic fibrosis NF-E2-related factor 2 NADPH quinone oxidoreductase 1 GlutathioneS-transferase

Silencing of signal transducer and activator of transcription 3 expression by RNA interference suppresses growth of human hepatocellular carcinoma in tumor-bearing nude mice被引量：13: 《World Journal of Gastroenterology》2009年第21期2602-2608,共7页Jing Li Yun-Feng Piao Zheng Jiang Li Chen Hai-Bo Sun; Supported by The Science and Technology Fund of Jilin Province,No. 200505219; AIM： To explore the effect of silencing of signal transducer and activator of transcription 3 （STAT3） expression by RNA interference （RNAi） on growth of human hepatocellular carcinoma （HCC） in tumorbearing nude...; 关键词：RNA interference Signal transducerand activator of transcription 3 transcription factor Hepatocellular carcinoma Xenograft model antitumorassays Nude mouse

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