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Functions of nuclear factor Y in nervous system development,function and health: 《Neural Regeneration Research》2025年第10期2887-2894,共8页Pedro Moreira Roger Pocock; supported by National Health and Medical Research Council GNT1105374,GNT1137645,GNT2000766 and veski Innovation Fellowship(VIF23)to RP.; Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 y...; 关键词：axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology: 《Neural Regeneration Research》2025年第9期2655-2666,共12页Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang; supported by the National Key R&D Program of China,No.2021YFA0805200(to SY);the National Natural Science Foundation of China,No.31970954(to SY);two grants from the Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(both to XJL)。; Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r...; 关键词：androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression: 《Neural Regeneration Research》2025年第7期2068-2083,共16页Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song; supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。; Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in...; 关键词：5′end trimming Alzheimer's disease AMYLOID-BETA amyloid-β-dependent transcription FUBP3 INFLAMMASOME inflammation neuron NLRP3 tau transcription factor

Transcription factor ELF4 in physiology and diseases:Molecular roles and clinical implications: 《Genes & Diseases》2025年第3期329-346,共18页Dian Hu Zerui Zhang Yijun Wang Siwen Li Jiaqian Zhang Zhangfan Wu Mengyu Sun Junqing Jiang Danfei Liu Xiaoyu Ji Shuai Wang Yufei Wang Xiangyuan Luo Wenjie Huang Limin Xia; funded by the National Natural Science Foundation of China(No.U23A20451,82273310,82372917,82173313);the Natural Science Foundation of Hubei Province,China(No.2022CFA016);the Basic Research Support Program of Huazhong University of Science and Technology(China)(No.2023BR038).; Transcription factor E74 like ETS transcription factor 4(ELF4),a member of the ETS family,is highly expressed in normal human hematopoietic tissue,ovary,placenta,colon,and certain pathological cell lines.During normal...; 关键词：BIOMARKER Cancer ELF4/MEF Immune system METASTASIS

Integration of transcriptome and metabolome reveals regulatory mechanisms of volatile flavor formation during tomato fruit ripening: 《Horticultural Plant Journal》2025年第2期680-692,共13页Zhiqiang Liu Jianxin Wu Licai Wang Xiaonan Lu Golam Jalal Ahammed Xiaolan Zhang Xia Cui Haijing Wang; supported by the National Natural Science Foundation of China(Grant Nos.32120103010,32002050);Beijing Joint Research Program for Germplasm Innovation and New Variety Breeding(Grant No.G20220628003-03);the Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences。; Tomato is an important economic crop all over the world.Volatile flavors in tomato fruit are key factors influencing consumer liking and commercial quality.However,the regulatory mechanism controlling the volatile fla...; 关键词：TOMATO Volatile flavor TRANSCRIPTOME Transcription factor CO-EXPRESSION

Brassica napus BnaWIP2 transcription factor promotes seed germination under salinity stress by repressing ABA biosynthesis and signaling: 《The Crop Journal》2025年第2期444-455,共12页Shuangcheng He Saiqi Yang Yuanchang Min Ankang Ge Junjin Liu Zijin Liu Yuan Guo Mingxun Chen; supported by the Biological Breeding-National Science and Technology Major Project(2022ZD04010);Scientific and Technological Innovation Team of Shaanxi Province(2024RS-CXTD-69);Key Research and Development Program of Shaanxi Province(2021LLRH-07);a grant from the Yang Ling Seed Industry Innovation Center(K3031122024).; Rapeseed(Brassica napus L.)is a global oil crop.Salinity stress impedes the growth of rapeseed,especially during seed germination.The key genes mediating salinity stress response during seed germination in B.napus rem...; 关键词：Rapeseed C2H2 zinc finger transcription factor Seed germination Abscisic acid Salt tolerance

Curcumol ameliorates diabetic retinopathy via modulating fat mass and obesity-associated protein-demethylated MAF transcription factor G antisense RNA 1: 《World Journal of Diabetes》2025年第4期220-235,共16页Han Rong Yu Hu Wei Wei; BACKGROUND Diabetic retinopathy(DR)is a major microvascular complication of diabetes mellitus,leading to significant visual impairment and blindness among adults.Current treatment options are limited,making it essenti...; 关键词：Diabetic retinopathy CURCUMOL MAF transcription factor G antisense RNA 1 Fat mass and obesity-associated protein Diabetes mellitus

Comparative transcriptomics analysis reveals stage-specific gene expression profiles associated with gamete formation in Garlic: 《Horticultural Plant Journal》2025年第2期839-853,共15页Jie Ge Jide Fan Yongqiang Zhao Xinjuan Lu Canyu Liu Biwei Zhang Qingqing Yang Mengqian Li Yan Yang Feng Yang; supported by the National Characteristic Vegetable Industry Technology System of China(Grant No.CARS24-A-07);the Jiangsu Modern Agricultural Industry Technology System Construction Special Fund(Grant No.JATS[2023]050);Xuzhou Academy of Agricultural Sciences Research Fund Project(Grant No.XM2021003)。; Commercial cultivars of garlic,a popular condiment,are sterile,making genetic variation and germplasm innovation of this plant challenging.Understanding mechanism of gamete sterility in garlic and their key regulatory...; 关键词：Allium sativum L. STERILITY MEIOSIS Genome expression Transcription factor TRANSCRIPTOME Ribosome biogenesis

Role of octamer transcription factor 4 in proliferation,migration,drug sensitivity,and stemness maintenance of pancreatic cancer cells: 《World Journal of Clinical Oncology》2025年第3期83-94,共12页Xue-Ying Shi Xi-Lan Wang Jin Zhao Shi-Hai Yang Cheng-Hai Zhang; Supported by Inner Mongolia Natural Science Foundation and the 3rd Affiliated of Inner Medical University,No.2021MS08067.; BACKGROUND Pancreatic cancer(PC)is one of the most aggressive malignancies characterized by rapid progression and poor prognosis.The involvement of cancer stem cells(CSCs)and Octamer transcription factor 4(OCT4)in PC ...; 关键词：Pancreatic cancer Octamer transcription factor 4 Cancer stem cells PROLIFERATION Drug sensitivity STEMNESS

SP7 transcription factor ameliorates bone defect healing in low-density lipoprotein receptor-related protein 5(LRP5)-dependent osteoporosis mice: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第3期254-268,共15页Yue XI Qifeng JIANG Wei DAI Chaozhen CHEN Yang WANG Xiaoyan MIAO Kaichen LAI Zhiwei JIANG Guoli YANG Ying WANG; Loss-of-function variants of low-density lipoprotein receptor-related protein 5(LRP5)can lead to reduced bone formation,culminating in diminished bone mass.Our previous study reported transcription factor osterix(SP7)...; 关键词：Gene therapy Low-density lipoprotein receptor-related protein 5(LRP5) Transcription factor osterix(SP7) OSTEOPOROSIS Defect healing

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