TRANSDUCTION

作品数：235被引量：648H指数：13
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Cre-recombinase systems for induction of neuronspecific knockout models:a guide for biomedical researchers被引量：1
《Neural Regeneration Research》2023年第2期273-279,共7页Tetiana Shcholok Eftekhar Eftekharpour 
Gene deletion has been a valuable tool for unraveling the mysteries of molecular biology.Early approaches included gene trapping and gene targetting to disrupt or delete a gene randomly or at a specific location,respe...
关键词：central nervous system CEREBELLUM Cre/LoxP system Cre-recombinase transduction gene deletion gene delivery hippocampus in vivo genome editing stereotaxic injection 
AAV8 transduction capacity is reduced by prior exposure to endosome-like pH conditions
《Neural Regeneration Research》2021年第5期851-855,共5页Jeffrey ALowell Kar Men Mah John LBixby Vance PLemmon 
This work was supported by grants to JLB and VPL from the National Institutes of Health(NS100531);the Craig H.Neilsen Foundation(598684);the Miami Project to Cure Paralysis.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience.
Adeno-associated virus(AAV)is an essential instrument in the neuroscientist’s toolkit,which allows delivery of DNA to provide labeling with fluorescent proteins or genetic instructions to regulate gene expression.In ...
关键词：adeno-associated virus autolytic CAPSID low pH PROTEASE PROTEOLYTIC temperature TRAFFICKING TRANSDUCTION viral inactivation 
Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease被引量：1
《Neural Regeneration Research》2020年第10期1850-1851,共2页Eunju Leem Sang Ryong Kim 
supported by a grant from the National Research Foundation of Korea(NRF-2020R1A2C2007954)
Biological roles of astrocyte elevated gene-1(AEG-1):AEG-1,also known as metadherin,was originally identified as a human immunodeficiency virus-1-and tumor necrosis factor-alpha-inducible gene in human fetal astrocyte...
关键词：ELEVATED al. INVASION 
A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis被引量：4
《Neural Regeneration Research》2014年第11期1145-1153,共9页Xiqing Chai Weina Kong Lingyun Liu Wenguo Yu Zhenqing Zhang Yimin Sun 
supported by the National Natural Science Foundation of China,No.81273983;the Natural Science Foundation of Hebei Province of China,No.C2010001471;the Scientific Research Fund of Hebei Provincial Education Department in China,No.Q2012036
Hypoxia-inducible factor 1 （HIF-1） attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. In this study, we construct-ed a recombinant adeno...
关键词：nerve regeneration Alzheimer＇s disease adeno-associated virus hypoxia-inducible fac-tor 1~ apoptosis gene therapy calcium concentration TRANSDUCTION intracerebroventricular injec-tion NSFC grant neural regeneration 
Transactivating-transduction protein-polyethylene glycol modified liposomes traverse the blood-spinal cord and blood-brain barriers被引量：1
《Neural Regeneration Research》2012年第35期2784-2792,共9页Xianhu Zhou Chunyuan Wang Shiqing Feng Jin Chang Xiaohong Kong Yang Liu Shijie Gao 
sponsored by grants from the National Natural Science Foundation of China,No.30872603;the New Century Excellent Talents Program of the Ministry of Education of China,No.NCET-06-0251;the Applied Basic Research Programs of Science and Technology Commission Foundation of Tianjin,China,No.07JCYBJC10200
Naive liposomes can cross the blood-brain barrier and blood-spinal cord barrier in small amounts. Liposomes modified by a transactivating-transduction protein can deliver antibiotics for the treatment of acute bacteri...
关键词：liposomes transactivating-transduction protein polyethylene glycol blood-spinal cord barrier blood-brain barrier caudal vein fiuorescein isothiocyanate rat human breast adenocarcinomacells （MCF-7） cytobiology neural regeneration 
Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene following transplantation in vivo
《Neural Regeneration Research》2011年第19期1462-1466,共5页Guangchun Ji Fei Song Qi Xing Jian Liu Kedong Song Daqing Zhang Zihan Wang 
the Natural Science Foundation of Liaoning Province, China, No. 20092165
This experiment sought to observe the migration and distribution of bone mesenchymal stem cells transfected with the cytosine deaminase gone （BMSCs-CD/eGFP） after transplantation in vivo through three pathways. In a...
关键词：cytosine deaminase gone bone mesenchymal stem cells GLIOMA TRANSDUCTION MIGRATION 
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