supported by the National Key R&D Program of China(Grant No.2021YFF1201004);the National Natural Science Foundation of China(Grant No.82273358,No.81802306,No.81903002,No.81672821,No.82071742,No.32270926);Natural Science Foundation of Guangdong Province of China(Grant No.2019A1515012196,No.2022A1515012059).
Dysfunction of CD8^(+)T cells in the tumor microenvironment(TME)contributes to tumor immune escape and immunotherapy tolerance.The effects of hormones such as leptin,steroid hormones,and glucocorticoids on T cell func...