supported in partial by the National Natural Science Foundation of China(Nos.21232002,21372254,21621064 and 21672255)
A dermatan sulfate (DS) repeating disaccharide analog, β-L-idopyranosiduronate-(1→3)-2-amino-2- deoxy-4,6-di-O-sulfo-β-D-galactopyranoside, has been convergently synthesized and successfully applied to prepare ...
financially supported by National Natural Science Foundation of China(Nos.21402111,81473415);Basic research program of Shanxi Province(No.2015021039);Shanxi Scholarship Council of China(No.2015-020);science and technology innovation project of Shanxi Province(No.2016115)
An efficient route to the natural products bupleurynol and its analog(RB-2),isolated from Bupleuri Radix,was established based on versatile intermediate(15).In this synthetic route,Sonogashira and CadiotChodkiewic...
provided by Natural Science Foundation of Jiangsu Province(NoBK2008112);Department of Health of Jiangsu Province(NoH200624)
The synthesis and labeling of ^(99m)Tc-N^3-(N'-[2-sulfanyl-ethylamino)acetyl]-2-aminoethyl-sulfanyl-1-hexanamide}thymidine (^(99m)Tc-NHT) were studied.In the presence of sodium glucoheptonate(GH) and ethyle...
An analog of phthalascidin (Pt-650) was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor te...
Financial support from Funding to Outstanding Doctor Thesis Authors of Chinese Universities (Grant No. 199949) is gratefully acknowledged by W. S. Fang.
A 2a-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin III 3 via double inversion of C-2 configuration. This compound showed very weak cytotoxicity toward several tumo...
We synthesised a natural product (10), isolated from G. parvifolium, and its analog. The synthetic product was characterized by elemental analysis and H-1-NMR in comparision with the corresponding natural product.
Secondary structure of [Val. Ala]sCT- an analog of salmon calcitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform intrared spectroscopy (FTIR) ...
Two types of N-phenyl and N,N-diphenyl azathiacrown ether analogs, Which contain two sulfur atoms, one or two oxygen atoms. and one or two nitrogen atoms, were synthesized by the reaction of an appropriate halide with...