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AΒ: 作品数：2698被引量：8108H指数：25; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：姚志彬王延江汪华侨祝其锋谢朝阳更多>>; 相关机构：中国医科大学山东大学中山大学山西医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>

艾灸“得气”对阿尔茨海默病模型大鼠脑海马Aβ受体介导转运和酶降解相关蛋白的影响被引量：5: 《中国针灸》2022年第8期899-906,共8页吕志迈黄丹丹谢丁一岳瑞珍王金伟罗蔚锋陈日新; 国家重点基础研究发展(“973”)计划项目:2015CB554503;江西省2011协同创新中心:灸疗研究与临床转化协同创新中心。; 目的:观察艾灸“得气”对阿尔茨海默病(Alzhemier’s disease, AD)模型大鼠的疗效及脑内β淀粉样蛋白(Aβ)转运和降解相关酶蛋白表达的影响,探讨其改善认知功能的分子机制。方法:将60只SPF级SD雄性大鼠随机分为空白组(8只)、假手术组(8...; 关键词：阿尔茨海默病艾灸穴大椎得气 Aβ受体介导转运 Aβ降解相关酶

Targeting the Transnitrosylation Cascade Provides a Novel Therapeutic Strategy for Alzheimer’s Disease被引量：2: 《Neuroscience Bulletin》2021年第9期1373-1376,共4页Yi Liu Gang Wu Xiji Shu Xiaochuan Wang; This research highlight article was supported by grants from the National Natural Science Foundation of China(92049107 and 31771114);Innovative Research Groups of the National Natural Science Foundation of China(81721005);the Ministry of Science and Technology of China(2016YFC1305800)。; As a major public health problem in modern society,Alzheimer’s disease(AD)is currently the most widely prevalent neurodegenerative disease,which will indubitably increase dramatically in the coming years,unless drugs...; 关键词：ALZHEIMER DRUGS AΒ

Advances in Drug Therapy for Alzheimer’s Disease被引量：7: 《Current Medical Science》2020年第6期999-1008,共10页Chuan-cong ZHU Si-yu FU Yu-xin CHEN Ling LI Ruo-lin MAO Jian-zhi WANG Rong LIU Yi LIU Xiao-chuan WANG; This study was supported by the Ministry of Science and Technology of China(No.2016YFC1305800);the National Natural Science Foundation of China(No.31771114 and No.31929002);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Academic Frontier Youth Team Project to Xiao-chuan WANG from Huazhong University of Science and Technology。; Alzheimer’s disease(AD)is a chronic neurodegenerative disease that mainly causes dementia.It is a serious threat to the health of the global elderly population.Considerable money and effort has been invested in the d...; 关键词：Alzheimer’s disease AΒ TAU drug therapy

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models被引量：6: 《Signal Transduction and Targeted Therapy》2019年第1期149-160,共12页Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong; This work was supported by grants from the National Natural Science Foundation of China(NSFC)(grant no.91749116,81622015,81671257,and 81571042);the National Basic Research Program of China(grant no.2014CB548100);the Science and Technology Research Program of Chongqing Municipal Education Commission(grant no.KJZD-K201900403);the Innovation Research Group at Institutions of Higher Education in Chongqing(grant no.CXQTP19019019034).; Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has ...; 关键词：ALZHEIMER AΒ IMPAIRMENT

Reduced Smoothened level rescues Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease被引量：3: 《Journal of Genetics and Genomics》2018年第5期237-246,共10页Weiwei Ma Mengnan Wu Siyan Zhou Ye Tao Zuolei Xie Yi Zhong; supported by grants from the National Science Foundation of China(Nos.91332207 and 91632301,to Yi Zhong);the Beijing Municipal Science and Technology Commission(Z161100002616010,to Yi Zhong);the National Basic Research Project(973 program)of the Ministry of Science and Technology of China(2013cb835100,to Yi Zhong);the Tsinghua-Peking Joint Center for Life Sciences; Emerging evidence suggests that neuro-inflammation begins early and drives the pathogenesis of Alzheimer＇s disease （AD）, and anti-inflammatory therapies are under clinical development. However, several anti-inflamm...; 关键词：Alzheimer disease INFLAMMATION Learning and memory SMOOTHENED

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia被引量：12: 《Protein & Cell》2016年第6期417-433,共17页Jintao Bao Liangjun Zheng Qi Zhang Xinya Li Xuefei Zhang Zeyang Li Xue Bai Zhong Zhang Wei Huo Xuyang Zhao Shujiang Shang Qingsong Wang Chen Zhang Jianguo Ji; Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid pla- que pathogenesis in Alzheimer＇s disease （AD）. Recent evidence suggests that lysosomal dysfunction leads to i...; 关键词：Alzheimer＇s disease microglia lysosomes TFEB SIRT1 DEACETYLATION

益肾化浊方对Aβ_(25-35)介导神经干细胞增殖与分化的影响被引量：6: 《中国实验方剂学杂志》2015年第20期99-102,共4页韩文文张玉莲周震张琳琳王凯宋宛珊崔远武; 国家自然科学基金项目(81102577);国家重点基础研究发展计划(973计划)项目(2010CB530405); 目的:观察益肾化浊方对阿尔茨海默病(AD)脑中神经干细胞(NSCs)增殖分化的影响,为益肾化浊方治疗AD提供实验依据。方法:分离孕14 d小鼠胚胎NSCs,并以β淀粉样蛋白25-35(Aβ25-35)处理,分为空白组(正常培养基),模型组(5μmol·L-1Aβ25-35...; 关键词：阿尔茨海默病益肾化浊方神经干细胞神经元星形胶质细胞

Chemically exfoliated WS2 nanosheets efficiently inhibit amyloid β-peptide aggregation and can be used for photothermal treatment of Alzheimer＇s disease被引量：5: 《Nano Research》2015年第10期3216-3227,共12页Meng Li Andong Zhao Kai Dong Wen Li Jinsong Ren Xiaogang Qu; This work was supported by the National Basic Research Program of China （Nos. 2011CB936004 and 2012CB720602）, and the National Natural Science Foundation of China （Nos. 21210002, 91213302, 21431007, and 91413111）.; Polymerization of amyloid-β peptide （Aβ） into amyloid fibrils is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of Aβ aggregation and destabilization of preformed Aβ fibrils have ...; 关键词：Alzheimer disease WS2 nanosheets Aβ inhibitors photothermal treatment Aβ aggregation near infrared （NIR）

益智胶囊对Aβ_(1-42)致阿尔茨海默病大鼠学习记忆障碍的影响被引量：4: 《中成药》2014年第11期2233-2237,共5页李雪娜李向军王宏涛朱慧明魏刚刘雪涛; 国家重点基础研究发展计划(973计划)(2012CB518606); 目的观察益智胶囊(管花肉苁蓉、刺五加、益智仁、丹参)对注射Aβ引起阿尔茨海默病大鼠学习记忆能力的影响,并对其可能的机制进行初步探讨。方法将SD大鼠随机分为7组。假手术组右侧海马单次注射生理盐水5μL,模型组、石杉碱甲组及益智胶...; 关键词：益智胶囊 AΒ1-42 海马 MORRIS水迷宫炎症神经元凋亡

何首乌有效成分二苯乙烯苷对Aβ_(25-31)诱导神经干细胞定向分化的影响被引量：25: 《中医杂志》2014年第4期323-327,共5页张玉莲周震韩文文宋宛珊黄建华张琳琳; 国家重点基础研究发展计划("973"计划)资助项目(2010CB530405); 目的探讨何首乌有效成分二苯乙烯苷(TSG)对β-淀粉样肽(Aβ25-31)诱导神经干细胞(NSCs)定向分化的影响。方法从孕14d昆明小鼠体外提取并培养NSCs,分别建立起两组分化系统可溶性Aβ25-31体外诱导NSCs损伤的阿尔茨海默病(AD)细胞模型:神...; 关键词：何首乌二苯乙烯苷阿尔茨海默病 Β-淀粉样肽定向分化神经元细胞星形胶质细胞

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