CANCER_CELLS

作品数：433被引量：1403H指数：15
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Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli被引量：4
《Signal Transduction and Targeted Therapy》2021年第7期2238-2250,共13页Hao Wu Yuqi Wang Minfeng Ying Chengmeng Jin Jiangtao Li Xun Hu 
This work has been supported in part by the China National 973 project(2013CB911303);China Natural Sciences Foundation projects(81470126);a key project(2018C03009)funded by Zhejiang Provincial Department of Sciences and Technologies;the Fundamental Research Funds for the Central Universities(2017XZZX001-012019FZJD009);National Ministry of Education,China,to X.H.,and Zhejiang Provincial Natural Science Foundation of China(LY17H160036);the Fundamental Research Funds for the Central Universities(2017FZA7010);China Natural Sciences Foundation project(81301707),to H.W.
Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase,but its physiological relevance is unknown.Here we showed that LDHA and LDHB both ex...
关键词：amplify CANCER OXIDATIVE 
Targeting peptide-decorated biomimetic lipoproteins improve deep penetration and cancer cells accessibility in solid tumor被引量：5
《Acta Pharmaceutica Sinica B》2020年第3期529-545,共17页Tao Tan Yuqi Wang Jing Wang Zhiwan Wang Hong Wang Haiqiang Cao Jie Li Yaping Li Zhiwen Zhang Siling Wang 
financially supported by the National Basic Research Program of China(2015CB932103);the National Natural Science Foundation of China(31771092,81521005,81690265);the Youth Innovation Promotion Association of Chinese Academy of Sciences and Fudan-SIMM Joint Research Fund(FU-SIMM20182005,China).
The limited penetration of nanoparticles and their poor accessibility to cancer cell fractions in tumor remain essential challenges for effective anticancer therapy.Herein,we designed a targeting peptide-decorated bio...
关键词：LIPOPROTEIN Drug delivery Tumor penetration Nanoparticles Cancer therapy 
Prion Protein Protects Cancer Cells against Endoplasmic Reticulum Stress Induced Apoptosis被引量：3
《Virologica Sinica》2019年第2期222-234,共13页Zhenxing Gao Min Peng Liang Chen Xiaowen Yang Huan Li Run Shi Guiru Wu Lili Cai Qibin Song Chaoyang Li 
supported by the Strategic Priority Research Program A of the Chinese Academy of Sciences (XDA12010309);the National Natural Science Foundation of China (31670170 and 31270209);the National Key R&D program of China (2018YFA0507201);the National Basic Research Priorities Program of China (2013CB911102) from the Ministry of Science and Technology of China
Unfolded protein response(UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum(ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, cancer cells may harness ER stress to f...
关键词：Endoplasmic reticulum stress Brefeldin A (BFA) PRION protein (PrP)- GLYCOSYLATION Apoptosis 
Biological effects of radiation on cancer cells被引量：7
《Military Medical Research》2018年第4期350-360,共11页Jin-Song Wang Hai-Juan Wang Hai-Li Qian 
financially supported by grants from the CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2016-I2M-1-001);the National Basic Research Program of China(973 Program)(No.2015CB553904);the National Natural Science Foundation of China(No.81372158,81372159,81572842,81672459);the Independent Issue of State Key Laboratory of Molecular Oncology(No.SKL-2017-16)
With the development of radiotherapeutic oncology, computer technology and medical imaging technology, radiation therapy has made great progress. Research on the impact and the specific mechanism of radiation on tumor...
关键词：RADIATION CANCER CELLS BIOLOGICAL features Combinational THERAPY 
Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments被引量：9
《Acta Pharmacologica Sinica》2018年第3期425-437,共13页Hui GUO Shan KUANG Qiao-ling SONG Man LIU Xiao-xiao SUN Qiang YU 
This work was supported by the China Ministry of Science and Technology Key New Drug Creation and Manufacturing Program （No 2014ZX9102001002 to Qiang YU）, the China National Key Basic Research Program （No 2013CB9i0900 to Qiang YU）, and the National Natural Science Foundation of China （No 81373447 and 81673465 to Qiang YU）.
STAT1 and STAT3 are two important members of the STAT （signal transducers and activators of transcription） protein family and play opposing roles in regulating cancer cell growth. Suppressing STAT3 and/or enhancing ...
关键词：cucurbitacin I cancer cells STAT1 STAT3 ACTIN phosphorylation 
Apoptotic Signal Pathways and Regulatory Mechanisms of Cancer Cells Induced by IL-24
《Wuhan University Journal of Natural Sciences》2016年第6期519-530,共12页LIU Huilin CHEN Jiaojiao JIANG Xingyan WANG Tao XIE Xiaoyuan HU Hui YU Fang WANG Xingzhi FAN Handong 
Supported by the National Program on Key Basic Research Project(973 Program)(2012CB518900);the National Natural Science Foundation of China(31160240,31260621);the 12th Five Years Key Programs for Science and Technology Development of China(2012ZX10002006);the Hangzhou Normal University Supporting Project(PE13002004042);the Natural Science Foundation of China of Jiangxi(20114BAB204016)
The melanoma differentiation-associated gene-7（mda-7）,IL-24,has the specific functions that induce cancer cell apoptosis without doing harm to normal cells. We systematically review the apoptotic signal pathways and...
关键词：apoptosis IL-24 signal pathway tumor 
Anticancer strategies based on the metabolic profile of tumor cells： therapeutic targeting of the Warburg effect被引量：10
《Acta Pharmacologica Sinica》2016年第8期1013-1019,共7页Xi-sha CHEN Lan-ya LI Yi-di GUAN Jin-ming YANG Yan CHENG 
This work was supported by grants from the National Basic Research Program of China （973 Program, 2015CB910700） （Yan CHENG） and the National Natural Science Foundation of China （81422051, 81472593, and 31401208） （Yan CHENG）.
Tumor cells rely mainly on glycolysis for energy production even in the presence of sufficient oxygen, a phenomenon termed the Warburg effect, which is the most outstanding characteristic of energy metabolism in cance...
关键词：glycolysis cancer cells cancer cells metabolism Warburg effect anticancer strategy 
Relationship of VEGF/VEGFR with immune and cancer cells:staggering or forward?被引量：10
《Cancer Biology & Medicine》2016年第2期206-214,共9页Yu-Ling Li Hua Zhao Xiu-Bao Ren 
supported by grants from the key program of the National Basic Research Program of China (973 program) (Grant No. 2012CB9333004);the National Natural Science Foundation of China (Grant No. 81401888)
Vascular endothelial growth factor(VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium. However, recent studies have shown...
关键词：Vascular endothelial growth factor （VEGF） VEGF receptors （VEGFRs） dendritic cell （DC） MACROPHAGE T lymphocyte tumor 
A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity被引量：4
《Signal Transduction and Targeted Therapy》2016年第1期31-40,共10页Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng 
This work was supported by The National Key Basic Research Program(973 Program)of China(2012CB917104 and 2013CB967201);National Natural Science Foundation of China Program grant(No:81372445);National Institute of Health grant(AI109317-01A1 and AI109373-01).
Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating im...
关键词：VACCINE immunity simultaneous 
Facile construction of carbon dots via acid catalytic hydrothermal method and their application for target imaging of cancer cells被引量：10
《Nano Research》2016年第1期214-223,共10页Zhenggang Wang Boshi Fu Siwei Zou Bo Duan Chunyu Chang Bai Yang Xiang Zhou Lina Zhang 
This work was supported by the Major Program of National Natural Science Foundation of China （No. 21334005）, the National Natural Science Foundation of China （Nos. 21304021 and 21432008）, and the National Basic Research Program of China （Nos. 2010CB732203 and 2012CB720603）.
To solve the problem of high temperature or long reaction time in hydrothermal synthesis of carbon dots （CDs）, a novel method based on the promoting carbonization by hydrochloric acid as catalysis was developed in p...
关键词：hydrothermal method carbon dots carbon nanomaterials DNA-aptamer BIOIMAGING 
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