Protein aggregates,mitochondrial import stress and neurodegenerative disorders:A salient hallmark of several neurodegenerative diseases,including Parkinson’s disease,is the abundance of protein aggregates(Goiran et a...
Supported by the Shandong Province Medical and Health Technology Development Plan,No.202204011069.
BACKGROUND Peripherally inserted central catheters(PICCs)are widely used for administering chemotherapy to breast cancer patients due to their long-term indwelling capability,versatility in drug administration,and fle...
supported by a grant from the General Research Fund(CityU 11102918)of the Research Grants Council of Hong Kong SAR of China.
Hypoxia is one of the most pressing global challenges affecting aquatic ecosystems and is primarily driven by global warming and eutrophication.17α-ethinylestradiol(EE2),a representative endocrine-disrupting chemical...
BACKGROUND Ileum adenocarcinoma(IA),a type of small bowel adenocarcinoma,is a rather uncommon factor associated with obstruction in small bowel.Owing to its location and indefinite clinical symptoms,the diagnosis of I...
Mitochondrial cytopathies are characterized by energy failure within the cellular system.These disorders exhibit a wide range of clinical presentations and are highly heterogeneous.The mitochondrial diseases include m...
BACKGROUND Dystrophic epidermolysis bullosa is characterized by fragile ulcerations of the skin caused by mutations in specific genes.However,genetic typing of this con-dition is rare.CASE SUMMARY An 11-year-old femal...
Supported by the National Natural Science Foundation of China(No.82271132).
Dear Editor,Leber congenital amaurosis with early-onset deafness syndrome(LCAEOD,OMIM 617879)is a rare autosomal dominant syndromic disease that was first described in 2017.The TUBB4B gene,encoding the betatubulin 4B ...
supported by grants from the Excellent Youth Incubation Program of Chinese People's Liberation Army General Hospital (No.2020-YQPY-007);the Natural Science Foundation of Hainan Province,China (No.821QN389,821MS117,823MS161,820MS124,821MS112,822MS198,820MS126,820QN383,822MS193);the Military Medical Science and Technology Youth Incubation Program (China) (No.20QNPY110,19QNPY060);the Key R&D Program of Hainan Province,China (No.ZDYF2023SHFZ145);the Health Care Project of PLA (China) (No.22BJZ30);the Clinical Medical Research Center Project of Hainan Province,China (LCYX202106,LCYX202201,LCYX202303);the National Key R&D Program of China (No.2018YFC2000400);the National S&T Resource Sharing Service Platform Project of China (No.YCZYPT[2018]07);the Specific Research Fund of Innovation Platform for Academicians of Hainan Province,China (No.YSPTZX202216);the Heatstroke Treatment and Research Center of PLA (China) (No.413EGZ1D10);the Major Science and Technology Programme of Hainan Province,China (No.ZDKJ2019012).
B-type natriuretic peptide(BNP)system is critical to cardiovascular physiological and pathological processes,especially in the development and progression of heart failure(HF)caused by dilated cardiomyopathy(DCMHF).1,...
Objective:To explore the adverse reactions associated with antibiotics and analyze strategies for their rational use.Methods:A retrospective analysis was conducted on 60 patients who experienced adverse reactions to a...
supported by grants from the National Natural Science Foundation of China(32125031);the Fundamental Research Funds for the Central Universities(JUSRP222001);Collaborative Innovation Center for Food Safety and Quality Control,China。
Aflatoxin B_1(AFB_1)is a common contaminant in cereals of global concern,and long-term low-dose exposure can adversely affect human health.Here,we showed that populations with dietary patterns characterized by high-fa...