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Constipation aff ects more than 14%of the global population with complex pathogenesis.Compound Traditional Chinese medicines(TCM),such as CDD-2101,a manufactured version of a time-tested TCM,hold great promise for con...
supported by National Key Research and Development Program of China(2018YFA0108500);NSFC82341006,81673334,31970740,31801144,31800684 and 31701227;Natural Science Foundation of Beijing(IS23071);Postdoctoral Research Foundation of China(2021M703206);Natural Science Foundation of Shanxi Province(202203021211155);the State Key Laboratory of Membrane Biology.
Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug resistance.Given its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS ...