CORTICAL_NEURONS

作品数：91被引量：300H指数：9
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相关作者：开丽薛春生王中峰华田苗化国鹏更多>>
相关机构：第三军医大学天津医科大学中国科学院上海生命科学研究院重庆医科大学更多>>
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Whole-brain Mapping of Inputs and Outputs of Specific Orbitofrontal Cortical Neurons in Mice
《Neuroscience Bulletin》2024年第11期1681-1698,共18页Yijie Zhang Wen Zhang Lizhao Wang Dechen Liu Taorong Xie Ziwei Le Xiangning Li Hui Gong Xiao-Hong Xu Min Xu Haishan Yao 
supported by the STI2030-Major Projects(2021ZD0203700/2021ZD0203703);the National Natural Science Foundation of China(31771151 and 32171030 to H.Y.,32100829 to D.L.);the Lingang Lab(Grant LG202104-01-03);Shanghai Municipal Science and Technology Major Project(grant No.2018SHZDZX05);the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB32010200).
The orbitofrontal cortex(ORB),a region crucial for stimulus-reward association,decision-making,and flexible behaviors,extensively connects with other brain areas.However,brain-wide inputs to projection-defined ORB neu...
关键词：Orbitofrontal cortex Projection specific Rabies virus retrograde tracing Anterograde transsynaptic virus tracing Inhibitory neurons 
Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells,Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice
《Neuroscience Bulletin》2023年第7期1131-1145,共15页Xue Li Shimin Zou Xiaomeng Tu Shishuai Hao Tian Jiang Jie-Guang Chen 
supported by the Wenzhou Municipal Science and Technology Bureau(Y20210901);the Natural Science Foundation of Zhejiang Province(LQ20H090001);the Scientific Research Fund of Wenling Science and Technology Bureau(2018C320001).
Heterozygous loss-of-function variants of FOXP4 are associated with neurodevelopmental disorders(NDDs)that exhibit delayed speech development,intellectual disability,and congenital abnormalities.The etiology of NDDs i...
关键词：NEUROGENESIS Radial migration Radial glial cell Ventricular zone N-CADHERIN 
Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
《Neuroscience Bulletin》2022年第10期1139-1152,共14页Yuan-Jie Xiao Lidan Wang Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru Wang 
This work was supported by grants from the National Natural Science Foundation of China(31970957 and 31471078);the Shanghai Science and Technology Commission(19ZR1416600);funding from 2021-JCJQ-JJ-1089.
Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in bra...
关键词：Crossmodal input Crossmodal response Crossmodal plasticity Sensory cortex Crossmodal task Sensory loss GABAergic transmission 
NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury被引量：4
《Neuroscience Bulletin》2020年第3期277-288,共12页Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye 
the National Natural Science Foundation of China(81570840 and 81200926);the Academician-Led Science and Technological Innovation of Chongqing(cstc2017jcyj-yszxX0006);the Research Foundation of the Department of Ophthalmology in Daping Hospital,AMU(9-2543).
In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impai...
关键词：NLRP3 VISUAL CORTEX Optic nerve injury VISUAL CORTICAL DEGENERATION 
Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex
《Neuroscience Bulletin》2018年第5期759-768,共10页Yan-Lin He Kai Wang Qian-Ru Zhao Yan-Ai Mei 
supported by the National Natural Science Foundation of China(31370827);the Shanghai Leading Academic Discipline Project [B111]
Cyproheptadine （CPH）, a first-generation anti- histamine, enhances the delayed rectifier outward K＋ current （IK） in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this stu...
关键词：CYPROHEPTADINE Neuronal excitability Te-traethylammonium-sensitive Ik cortical neurons Sigma-1 receptor 
Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse
《Neuroscience Bulletin》2014年第3期425-432,共8页Yan Hu Sen Li Hua Jiang Ming-Tao Li Jia-Wei Zhou 
supported by grants from the Chinese Academy of Sciences;the National Basic Research Development Program of China (2011CB504102);the National Natural Science Foundation of China (31123002 and 31321091)
Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of...
关键词：neuron migration Eph receptor A4 ephrin-B2 cerebral cortex development 
Neurotrophic effects of 7,8-dihydroxycoumarin in primary cultured rat cortical neurons被引量：3
《Neuroscience Bulletin》2012年第5期493-498,共6页Li Yan Xiaowen Zhou Xing Zhou Zheng Zhang Huan-Min Luo 
supported by grants from the National Natural Science Foundation of China (30672450);the National Basic Research Development Program (973 Program) of China (2011CB707500);the Third Stage Construction Funds of National "Project 211", Department of Education, China (2005–2010)
Objective Neuronal loss in the central nervous system is central to the occurrence of neurodegenerative diseases. Pharmaceutical companies have devoted much effort to developing new drugs against such diseases, since ...
关键词：7 8-dihydroxycoumarin DAPHNETIN rat cortical neurons brain-derived neurotrophic factor neurodegenerative disease 
Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via anti-apoptosis被引量：4
《Neuroscience Bulletin》2012年第5期509-516,共8页Xuemei Wu Jing Zhao Shanshan Yu Yanlin Chen , Jingxian Wu Yong Zhao 
supported by grants from the National Natural Science Foundation of China (30900457 and 81070917)
Objective To determine whether sulforaphane （SFN） protects neurons against injury caused by oxygen-glucose deprivation/reoxygenation （OGD/R） and, if so, to investigate the possible mechanisms. Methods Primary cult...
关键词：SULFORAPHANE oxygen-glucose deprivation apoptosis NEUROPROTECTION 
Knock-down of postsynaptic density protein 95 expression by antisense oligonucleotides protects against apoptosis-like cell death induced by oxygen-glucose deprivation in vitro被引量：1
《Neuroscience Bulletin》2012年第1期69-76,共8页Jing-Zhi Yan Yong Liu Yan-Yan Zong Guang-Yi Zhang 
supported by the National Natural Science Foundation of China (30170220);Xuzhou Science and Technology Bureau of China (XZZD1157);Xuzhou Medical College (2011KJZ03);A Project Funded by the Priority Academic Program Development of Jingsu Higher Education Institutions
Objective Postsynaptic density protein 95 （PSD-95） plays important roles in the regulation of glutamate signaling, such as that of N-methyl-D-aspartate receptors （NMDARs）. In this study, the functional roles of PS...
关键词：postsynaptic density protein 95 N-methyl-D-aspartate receptor oxygen-glucose deprivation tyrosine phos-phorylation SRC cortical neurons 
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