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The Regulatory Role and Mechanism of Circadian Rhythm in Hemoglobin Co-cultured Neurovascular Unit
《Biomedical and Environmental Sciences》2024年第7期726-738,共13页Fang Xue Wenchao Chen Xia Lian Guanghui He Jingyuan Tian Yinghong Liu Gaiqing Wang 
supported by the National Natural Science Foundation of China(No.82160237);the Key Research and Development Program in Hainan Province(No.ZDYF2023SHFZ104);Natural Science Foundation of Hainan Province(No.822MS210).
Objective Intracranial hemorrhage(ICH),the second most common subtype of stroke,exacerbates the disruption of the blood-brain barrier(BBB),leading to vasogenic edema,plasma protein extravasation,and infiltration of ne...
关键词：Blood-brain barrier Circadian rhythm Neurovascular unit Melatonin receptor 1A AQUAPORIN-4 
Hexabromocyclododecane-induced Genotoxicity in Cultured Human Breast Cells through DNA Damage被引量：2
《Biomedical and Environmental Sciences》2017年第4期296-300,共5页LI Rui Jing GAO Hui NA Guang Shui LU Zi Hao YAO Yao YANG Fan 
supported by the National Natural Science Foundation of China(No.41406088);The open fund of Key Laboratory for Ecological Environment in Coastal Areas,State Oceanic Administration(201506)
To investigate the genotoxicity and reveal the potential toxicological mechanisms of Hexabromocyclododecane （HBCD）, human breast cells HBL-100 were exposed to a sequence of HBCD concentrations （0, 5, 10, and 50 mg/...
关键词：DNA HBCD Hexabromocyclododecane-induced Genotoxicity in Cultured Human Breast Cells through DNA Damage 
Glutamate Impairs Mitochondria Aerobic Respiration Capacity and Enhances Glycolysis in Cultured Rat Astrocytes被引量：6
《Biomedical and Environmental Sciences》2017年第1期44-51,共8页YAN Xu SHI Zhong Fang XU Li Xin LI Jia Xin WU Min WANG Xiao Xuan JIA Mei DONG Li Ping YANG Shao Hua YUAN Fang 
supported by the National Natural Science Foundation of China,No.81271286;Beijing Natural Science Foundation,No.7152027 to YUAN Fang;Innovation Foundation of Beijing Neurosurgical Institute,No.2014-11 to YAN Xu
Objective To study the effect of glutamate on metabolism, shifts in glycolysis and lactate release in rat astrocytes. Methods After 10 days, secondary cultured astrocytes were treated with 1 mmol/L glutamate for 1 h, ...
关键词：ASTROCYTES GLUTAMATE Mitochondrial metabolism GLYCOLYSIS LACTATE 
Protective Effect of 10-Hz,1-mT Electromagnetic Field Exposure Against Hypoxia/Reoxygenation Injury in HK-2 Cells
《Biomedical and Environmental Sciences》2015年第3期231-234,共4页Soonho Lim Soo-Chan Kim Jae Young Kim 
supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Education,Science and Technology(NRF-2009-0082941)
We investigated the protective effects of electromagnetic field（EMF）on the survival of the human renal proximal tubular cell line,HK-2,using an in vitro hypoxia/reoxygenation（H/R）injury model.The survival rate of ...
关键词：proximal protective declined exposure intracellular cultured tubular exposed markedly suppression 
Effects of Fenvalerate on Steroidogenesis in Cultured Rat Granulosa Cells被引量：2
《Biomedical and Environmental Sciences》2005年第2期108-116,共9页JIAN-FENGCHEN HAI-YANCHEN RULIU JUNHE LINSONG QIANBIAN LI-CHUNXU JIAN-WEIZHOU HANGXIAO GUI-DONGDAI XIN-RUWANG 
ThisworkwassupportedbygrantsfromNationalNaturalScienceFoundationofChina(No.C03010501),aPreliminaryStudyoftheGreastSpecialProjectintheNationalBasicResearch(2001CCA04900),andtheGreastSpecialProjectintheNationalBasicResearch(2001-CCA04900,andtheGreastSpecialProjectintheNationalBasicResearch(2002CB512908).
Objective This study was designed to examine the in vitro effects of fenvalerate on steroid production and steroidogenic enzymes mRNA expression level in rat granulosa cells. Methods Using primary cultured rat granulo...
关键词：Endocrine disruptor PYRETHROID Steroidogenesis Granulosa cell RAT 
Effect of Dynein Inhibitor on Mouse Oocyte in vitro Maturation and Its Cyclin B1 mRNA Level
《Biomedical and Environmental Sciences》2004年第3期341-349,共9页XIAO-MEIWANG TIAN-HUAHUANG QING-DONGXIE QING-JIANZHANG YERUAN 
This work was supported by a grant from the National Natural Science Foundation of China (No. 30170481).
Objective To evaluate the effect of dynein inhibitor on mouse oocyte in vitro maturation and its cyclin B1 transcription level. Methods Immature mouse oocytes were cultured in vitro with a known dynein ATPase activ...
关键词：DYNEIN OOCYTES Cultured in vitro maturation (CVM) Cyclin B1 Sodium orthovanadate (SOV) 
Flow Cytometric Analysis of the Toxicity of Nitrofen in Cultured Keratinocytes被引量：6
《Biomedical and Environmental Sciences》1999年第2期144-149,共6页YIN LEI  JIN XI-PENG YU XIAO-ZHONG AND LIN HUI-FEN(Laboratory of Skin Physiology and Toxicology, School of Public Health,Shanghai Medical University, Shanghai 200032, China Department of Dermatology, for City University, for 466, Japan) 
Lactate dehydrogenase (LDH) release test, 3 H-thymidine (3 H-TdR) and 3 H-leucine (3 H-Leu) incoopration tests and flow cytometric analysis (FCM) of cell cycle were empoyed to elucidate cellular and molecular mechanis...
关键词：Flow Cytometric Analysis of the Toxicity of Nitrofen in Cultured Keratinocytes 
Effect of 27-Hydroxycholesterol on Cellular Sphingomyelin Synthesis and Ca^(++) Content in Cultured Smooth Muscle Cells
《Biomedical and Environmental Sciences》1997年第4期369-376,共8页QIZHOU FREDA·ＫＵＭＭＥＲＯＷ 
The relationships among sphingomyelin synthesis, cytosoic free Ca+ + level and cytotoxi-city in the presence of 27-hydroxycholesterol were investigated by measurement of [methyl-3H] choline incorporation into sphingom...
Determinants of PHGPx Expression in a Cultured Endothelial Cell Line被引量：1
《Biomedical and Environmental Sciences》1997年第2期163-176,共14页REGINA BRIGELIUS-FLOHE B■RBEL FRIEDRICHS STEFANIE MAURER AND RUDIGER STREICHER (German Institute of Human Nutrition,D-14558 Potsdam-Rehbrucke, Germany) 
Selenoprotein biosynthesis may not only be affected by the availability of selenium and the transcription rate of pertinent genes but also by the activity of components of the selenocysteine incorporation complex, Sel...
关键词：ECV Determinants of PHGPx Expression in a Cultured Endothelial Cell Line 
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