DISEASES

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Understanding and modeling human traits and diseases:Insights from the comparative genomics resources of Zoonomia
《The Innovation》2023年第4期5-6,共2页Maosen Ye Deng-Feng Zhang 
supported by the Ministry of Science and Technology of China(STI2030-Major Projects-2022ZD0213500);the National Natural Science Foundation of China(82022017 and 31970965);the Youth Innovation Promotion Association of Chinese Academy of Sciences.
Understanding the genetic architecture of complex human traits and diseases is one of the major aims of biomedical research.Genetic research,such as genome-wide association studies(GWASs)of large-scale,wellphenotyped ...
关键词：DISEASES CLINICAL TRANSLATE 
Epigenetic regulation of aging:implications for interventions of aging and diseases被引量：7
《Signal Transduction and Targeted Therapy》2022年第12期4283-4304,共22页Kang Wang Huicong Liu Qinchao Hu Lingna Wang Jiaqing Liu Zikai Zheng Weiqi Zhang Jie Ren Fangfang Zhu Guang-Hui Liu 
National Key Research and Development Program of China(2020YFA0804000);Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16010000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);National Natural Science Foundation of China(81921006,92149301,92168201,92049116,32121001,82100140,31970597);National Key Research and Development Program of China(2020YFA08034012019YFA0802202);Program of the Beijing Natural Science Foundation(Z190019);Tencent Foundation(2021–1045),K.C.Wong Education Foundation(GJTD-2019-08),Youth Innovation Promotion Association of CAS(E1CAZW0401);Science&Technology Innovation 2030 of The Ministry of Science and Technology of China(2022ZD0214200).
Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks,including genetic and epigenetic alterations.These aging-associated epigenetic changes include DNA methylation,histone mo...
关键词：AGING PREVENTION hence 
Nanotechnology for cardiovascular diseases被引量：1
《The Innovation》2022年第2期17-37,共21页Qinqin Hu Zheyan Fang Junbo Ge Hua Li 
This work was supported by the National Natural Science Foundation of China(81521001,81870182,82000270,82170334);the National Key Basic Research Programme(2016YFC1301204,2020YFC1316700).
Cardiovascular diseases have become the major killers in today’s world,among which coronary artery diseases(CADs)make the greatest contributions to morbidity and mortality.Although state-of-the-art technologies have ...
关键词：DISEASES CARDIOVASCULAR DIAGNOSIS 
Liquid-liquid phase separation in human health and diseases被引量：15
《Signal Transduction and Targeted Therapy》2021年第9期2634-2649,共16页Bin Wang Lei Zhang Tong Dai Ziran Qin Huasong Lu Long Zhang Fangfang Zhou 
This work was supported by a special program from the Ministry of Science and Technology of China(2016YFA0502500 to L.Z.);the Chinese National Natural Science Funds(31925013,31671457,and 91753139 to L.Z.;31871405 and 31571460 to FZ.;92053114,32070632 to H.L.);Zhejiang Provincial Natural Science Foundation of China under Grant(LBY21H060001 to L.Z.);the Medical and the Medical and Health Research Project of Zhejiang Province(2020RC115 to L.Z.);Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.);the Zhejiang Natural Science Fund(LD19C070001to L.Z.);the China National Postdoctoral Program for Innovative Talents(BX2021208 to T.D.);the China Postdoctoral Science Foundation(2021M692350 to T.D.);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);A project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular conde...
关键词：SEPARATION DISEASES LIQUID 
Diversity,Geography,and Host Range of Emerging Mosquito-Associated Viruses—China,2010–2020
《China CDC weekly》2021年第35期746-750,I0002,I0003,I0004,共8页Yuan Fang Tian Hang Jinbo Xue Yuanyuan Li Lanhua Li Zixin Wei Limin Yang Yi Zhang 
The Special Foundation of Basic Science and Technology Resources Survey of Ministry of Science and Technology of China(No.2017FY101200);The Open Project of Key Laboratory of Parasite and Vector Biology,China Ministry of Health(No.WSBKFKT-201804);and The Fifth Round of Three-Year Public Health Action Plan of Shanghai(No.GWV-10.1-XK13).
Epidemics of emerging and neglected infectious diseases are severe threats to public health and are largely driven by the promotion of globalization and by international multi-border cooperation.Mosquitoborne viruses ...
关键词：DISEASES MORTALITY NEGLECTED 
The Ca^(2+)-activated chloride channel ANO1/TMEM16A:An emerging therapeutic target for epithelium-originated diseases?被引量：15
《Acta Pharmaceutica Sinica B》2021年第6期1412-1433,共22页Yani Liu Zongtao Liu KeWei Wang 
supported by grants from the National Natural Science foundation of China (81573410);the Ministry of Science and Technology of China (2018ZX09711001-004-006);Shandong Provincial Medicine and Health Technology Development Plan (2019WS145, China);Medical Research Guidance Plan of Qingdao Municipal Health Committee (2019-WJZD091, China);Qingdao Excellent Young Medical Talent Training Project。
Anoctamin 1(ANO1) or TMEM16 A gene encodes a member of Ca^(2+) activated Cl^(-) channels(CaCCs) that are critical for physiological functions,such as epithelial secretion,smooth muscle contraction and sensory signal t...
关键词：Ca^(2+)-activated Cl^(-)channels(CaCCs) ANO1 TMEM16A CaCCinh-A01 T16Ainh-A01 Drug target Cancer Cystic fibrosis 
Ferroptosis:mechanisms and links with diseases被引量：96
《Signal Transduction and Targeted Therapy》2021年第3期648-663,共16页Hong-fa Yan Ting Zou Qing-zhang Tuo Shuo Xu Hua Li Abdel Ali Belaidi Peng Lei 
Supported by funds from the Ministry of Science and Technology of China(2018YFC1312300);The National Natural Science Foundation of China(81722016,82071191);The Alzheimer’s Association(AARFD-16-442821).
Ferroptosis is an iron-dependent cell death,which is different from apoptosis,necrosis,autophagy,and other forms of cell death.The process of feroptotic cell death is defined by the accumulation of lethal lipid specie...
关键词：DISEASES PEROXIDATION DEATH 
Reported Cases of Respiratory Infectious Diseases--China,January−June,2018−2020
《China CDC weekly》2020年第38期747-748,共2页Songwang Wang Yewu Zhang Zunyou Wu Xuemei Su 
supported by Special Foundation of Basic Science and Technology Resources Survey of Ministry of Science and Technology of China(No.2017FY101207);Application of big data processing and analysis for pathogen monitoring of infectious disease syndromes based on cloud computing technology and construction of sharing platform(No.2018ZX10713001-012).
FIGURE 1.The number of respiratory infectious diseases(RID)and non-respiratory infectious diseases(non-RID)in China from January to June in 2018–2020.Respiratory infectious diseases included measles,tuberculosis,epid...
关键词：H7N9 RESPIRATORY DISEASES 
Preliminary study on fine structures of subcortical nuclei in rhesus monkeys by ex vivo 9.4 T MRI被引量：1
《Zoological Research》2020年第2期199-202,共4页Huan-Zhi Chen Hong-Yi Yang Kai Zhong Jia-Li Li 
supported by the Chinese Academy of Sciences(Y406541141 and 1100050210);National Natural Science Foundation of China(91649119);National Natural Science Foundation of China(91649101);Ministry of Science and Technology of China(2015CB755605 and 2016YFC1305902)to J.L.L.;National Key Research and Development Program of China(2016YFC1300500-503);Hefei Science Center(2017HSC-KPRD003);Hefei Institutes of Physical Science(YZJJ201702)to K.Z。
DEAR EDITOR,Changes in fine structures of the brain over a life span can have robust effects on neural activity and brain function,which both play crucial roles in neurodegenerative diseases.Clinically,however,low-res...
关键词：DIAGNOSIS CLINICAL DISEASES 
Reported Vector-Borne Diseases --China, 2018被引量：3
《China CDC weekly》2020年第14期219-224,共6页Qiyong Liu Yuan Gao 
supported by the National Basic Research Program of China(973 Program)(grant number 2012CB955504);the National Major Research and Development Program(grant number 2016YFC1200802).
Introduction:Vector-borne diseases are an important type of infectious disease in China.This study aims to present a summary of vector-borne diseases reported in China in 2018 to provide information on their control a...
关键词：DISEASES MORTALITY utilized 
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