DOW

作品数：743被引量：1078H指数：16
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Gender differences in air movement preference after moderate-intensity exercise
《Frontiers of Architectural Research》2025年第1期198-209,共12页Shiwu Zhang Shengkai Zhao Zhen Sun Yongchao Zhai 
supported by the National Natural Science Foundation of China(Grant Nos.51978553,51838011).
This study investigates the air movement preference of males and females aftermoderate-intensity exercise. 35 participants dressed in 0.6 clo exercised for 15 min in a roomat 30℃ and then entered another room at 24℃...
关键词：Thermal comfort Air movement Gender differences Metabolic down-step transient 
FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum
《Acta Pharmaceutica Sinica B》2025年第2期973-990,共18页Meiyu Shang Jingwen Ning Caixia Zang Jingwei Ma Yang Yang Yueqi Jiang Qiuzhu Chen Yirong Dong Jinrong Wang Fangfang Li Xiuqi Bao Dan Zhang 
supported by The National Key Research and Development Program of China(grant No.2023YFC3502800);the CAMS Innovation Found for Medical Sciences(No.2022-I2M-2-001,China).
Increasing evidence shows that the early lesions of Parkinson's disease(PD)originate from gut,and correction of microbiota dysbiosis is a promising therapy for PD.FLZ is a neuroprotective agent on PD,which has been va...
关键词：Parkinson's disease FLZ Glycoursodeoxycholic acid Clostridium innocuum Gut-brain axis Microbiota dysbiosis Microbial metabolites NEUROINFLAMMATION 
Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulatingα1,2-Fucosylation of Asah2 and Npc1
《Research》2024年第4期545-561,共17页Caihan Duan Zhe Wang Junhao Wu Chen Tan Feifei Fang Wei Qian Chaoqun Han Xiaohua Hou 
supported by the National Natural Science Foundation of China(grant nos.92268108,82170570,and 81974062).
Fut2-mediatedα1,2-fucosylation is important for gut homeostasis,including the intestinal stem cell(ISC).The stemness of ISC declines with age,and aging-associated ISC dysfunction is closely related to many age-relate...
关键词：IMPAIRED AGING ELEVATED 
Advances in the prerequisite and consequence of STING downstream signalosomes
《Medical Review》2024年第5期435-451,共17页Xinliang Lu Xiaobing Li Lili Li Chuanhui Han Sirui Li 
National Natural Science Foundation of China (82000003);China Postdoctoral Science Foundation (2023M743039);National Key Research and Development Program of China (2022YFC3401400).
The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)pathway is an evolving DNA-sensing mechanism involved in innate immunity and pathogen defense that has been optimized while remaining conserved.As...
关键词：stimulator of interferon genes signalosomes cellular heterogeneity cancer therapeutics 
Phosphorylation-dependent regulation of plant heterotrimeric G proteins:From activation to downstream signaling被引量：1
《Science Bulletin》2024年第19期2967-2970,共4页Miaomiao Ma Jian-Min Zhou Xiangxiu Liang 
supported by the National Natural Science Foundation of China(32300260 and 32270282);Double First-class Discipline Promotion Project(2021B10564001).
Heterotrimeric G proteins(G proteins)composed of Gα,Gβ,and G subunits are universal signaling modules in eukaryotes.In plants,G proteins regulate almost all aspects of biological processes,including plant growth,dev...
关键词：PLANT PHOSPHORYLATION ACTIVATION 
车辆开门预警系统(DOW)功能研究
《汽车维修技师》2024年第12期118-120,共3页乔林炎 师艳娟 吴家硕 许诺 
为减少开门事故的发生,本文对车辆开门预警系统进行功能研究,主要包含此系统的基础模块和系统报警策略,并对车辆开门预警系统功能场景进行描述。
关键词：开门预警 ADAS 报警策略 
Digital monitoring of rotary-percussive drilling with down-the-hole hammer for profiling weathered granitic ground
《Journal of Rock Mechanics and Geotechnical Engineering》2024年第5期1615-1636,共22页Wendal Victor Yue Siyuan Wu Manchao He Yafei Qiao Zhongqi Quentin Yue 
supported by grants from the Research Grant Council of the Hong Kong Special Administrative Region,China(Project Nos.HKU 7137/03E and R7005/01E)。
Rock and geotechnical engineering investigations involve drilling holes in ground with or without retrieving soil and rock samples to construct the subsurface ground profile.On the basis of an actual soil nailing dril...
关键词：Drilling process monitoring(DPM) Down-the-hole(DTH)hammer Percussive-rotary drilling Weathering granitic rocks 
The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer
《Genes & Diseases》2024年第2期542-545,共4页Jiyan Wang Tao He Qingle Gao Hongkai Chang Xintong Dai Juze Yang Shuangping Liu Shuai Zhang Changliang Shan Chunze Zhang 
supported by grants from National Nature Science Foundation of China(No.81973356,81902826 and 82273963);Natural Science Foundation of Tianjin(No.21JCZDJC00060 and 21JCYBJC00180);the Fundamental Research Funds for the Central Universities of Nankai University(No.ZB22010404,3206054,91923101,63213082,and 92122017).
The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy clinically.Microsatellite instability(MSI)is found in 10%-15%of colorectal can...
关键词：IMMUNOTHERAPY COLORECTAL clinical 
DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis
《Genes & Diseases》2024年第1期91-94,共4页Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du Chengang Zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi Chen 
supported by the National Key R&D Program of China(No.2020YFA0112300);the National Natural Science Foundation of China(No.81830087,U2102203,82173014,81872414);the Yunnan Fundamental Research Projects(China)(No.202101AS070050,202001AW070018);major projects for fundamental research of Yunnan Province,China(No.202201BC070002);CAS"Light of West China"”Young Scholar Program,and Yunnan Revitalization Talent Support Program(China)(Yunling Shcolar Project and Young Talent Project);the Guangdong Foundation Committee for Basic and Applied Basic Research projects(China)(No.2022A1515012420);the Guangdong Medical University Affiliated Hospital Competitive Clinical Study(China)(No.LCYJ2021B003);the Guangdong Province Characteristic Innovation Projects(China)(No.2021KTSCX037).
Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly ...
关键词：FOXO1 DRUGS damage 
PbrChiA:a key chitinase of pear in response to Botryosphaeria dothidea infection by interacting with PbrLYK1b2 and down-regulating ROS accumulation被引量：1
《Horticulture Research》2023年第10期185-201,共17页Qiming Chen Huizhen Dong Qionghou Li Xun Sun Xin Qiao Hao Yin Zhihua Xie Kaijie Qi Xiaosan Huang Shaoling Zhang 
This work has been supported by the National Key Research and Development Program of China(2018YFD1000300);the National Science Foundation of China(31872070,32072538),Fundamental Research Funds for the Central Universities(JCQY201901);the Earmarked Fund for China Agriculture Research System(CARS-28);the Jiangsu Agriculture Science and Technology Innovation Fund(SCX(22)3215).Bioinformatic analysis was supported by the Bioinformatics Center of Nanjing Agricultural University.We also thank Dr Jianming Zeng(University of Macao),and all the members of his bioinformatics team,biotrainee,for generously sharing their experience and codes.
Pear ring rot,caused by the pathogenic fungi Botryosphaeria dothidea,seriously affects pear production.While the infection-induced reactive oxygen species(ROS)burst of infected plants limits the proliferation of B.dot...
关键词：INFECTION CHIA resistance 
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