EXTRACELLULAR_MATRIX

作品数：418被引量：1435H指数：17
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3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity
《Bioactive Materials》2024年第12期316-327,共12页Theo Desigaux Leo Comperat Nathalie Dusserre Marie-Laure Stachowicz Malou Lea Jean-William Dupuy Anthony Vial Michael Molinari Jean-Christophe Fricain Francois Paris Hugo Oliveira 
the financial support of INSERM(France)and"Fondation ARC pour la recherche sur le cancer".
Deciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor microenvironment.Here,we show that microextrusion bioprint...
关键词：BIOPRINTING Cancer microenvironment Extracellular matrix 
Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity
《Bioactive Materials》2024年第11期640-656,共17页Sarah Jones Sabrina VandenHeuvel Andres Luengo Martinez Ruchi Birur Eric Burgeson Isabelle Gilbert Aaron Baker Matthew Wolf Shreya A.Raghavan Simon Rogers Elizabeth Cosgriff-Hernandez 
National Science Foundation Graduate Research Fellowship Program under Grant(award#2020300397);Any opinions,findings,conclusions,or recommendations expressed in this material are those of the author(s)and do not necessarily reflect the views of the National Science Foundation.
Decellularized extracellular matrices (dECM) have strong regenerative potential as tissue engineering scaffolds;however, current clinical options for dECM scaffolds are limited to freeze-drying its native form into sh...
关键词：ELECTROSPINNING EXTRACELLULAR matrix BIOLOGICAL scaffolds 
An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats
《Bioactive Materials》2024年第10期571-581,共11页Jialu Yao Junlang Li Dashuai Zhu Yuan Li Panagiotis Tasoudis Shuo Liu Xuan Mei Kristen Popowski Thomas G.Caranasos Haipeng Wang Mingzhu Xu Tingbo Jiang Kan Shen Hongxia Li Ke Huang 
supported by the American Heart Association(21CDA855570 to KH);JY is supported by Suzhou Youth Science and Technology Project(KJXW2023012 to JY);the Natural Science Foundation of Jiangsu Province(BK20231198);the Jiangsu Province Health Care Development Special Fund(M2022038)。
Chemotherapy-induced cardiotoxicity with subsequent heart failure(HF)is a major cause of morbidity and mortality in cancer survivors worldwide.Chemotherapy-induced HF is exceptionally challenging as it generally manif...
关键词：Secretomes Cardiac stromal cells Extracellular matrix Chemotherapy Heart failure Intrapericardial injection 
Immunomodulatory extracellular matrix hydrogel induces tissue regeneration in a model of partial glossectomy
《Bioactive Materials》2024年第8期528-539,共12页Emma I.Zelus Aaron Panduro Isha Deshmukh Jacqueline Grime Marianna Alperin Andrew M.Vahabzadeh-Hagh Karen L.Christman 
Funding provided by the UCSD Galvanizing Engineering in Medicine Program.The authors would like to thank the UC San Diego Stem Cell Genomics Core at the Sanford Consortium for Regenerative Medicine for assistance with RNA sequencing and analysis.
While oropharyngeal cancer treatment regimens,including surgical resection,irradiation,and chemotherapy,are effective at removing tumors,they lead to muscle atrophy,denervation,and fibrosis,contributing to the pathoge...
关键词：Extracellular matrix Biomaterial HYDROGEL Skeletal muscle regeneration Partial glossectomy DYSPHAGIA Immunomodulation 
Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis被引量：2
《Bioactive Materials》2024年第7期1-13,共13页Shaojun Hu Meng Zhu Hongyuan Xing Yucheng Xue Jun Li Zhan Wang Zhou Zhu Miaojie Fang Zilong Li Jianbin Xu Yong He Ning Zhang 
supported by the National Natural Science Foundation of China (grant No.81972514,32371412 and 32071349);Zhejiang Provincial Natural Science Foundation of China under Grant No.LY23H060008 and LY24C100001;National Health Commission Scientific Research Fund&Zhejiang Provincial Medical and Health Major Science and Technology Plan Project:WKJ-ZJ-2428.
Low back pain is among the most grave public health concerns worldwide and the major clinical manifestation of intervertebral disc degeneration(IVDD).The destruction of annulus fibrosus(AF)is the primary cause of IVDD...
关键词：Intervertebral disc degeneration MICRONEEDLE EXOSOMES Annulus fibrosus MITOPHAGY 
Engineering an extracellular matrix-functionalized,load-bearing tendon substitute for effective repair of large-to-massive tendon defects
《Bioactive Materials》2024年第6期221-237,共17页Shuting Huang Ying Rao Meng Zhou Anna M.Blocki Xiao Chen Chunyi Wen Dai Fei Elmer Ker Rocky S.Tuan Dan Michelle Wang 
funding support,including The Research Grants Council of Hong Kong SAR(GRF 14121121,DMW,GRF 14118620,DMW,ECS24201720,DFEK);National Natural Science Foundation of China/Research Grants Council Joint Research Scheme(N_CUHK409/23,DMW);The Innovation and Technology Commission of Hong Kong SAR Innovation Tier 3 Support(ITS/090/18,DFEK);Health@InnoHK CNRM(DMW,AB,DFEK,RST).
A significant clinical challenge in large-to-massive rotator cuff tendon injuries is the need for sustaining high mechanical demands despite limited tissue regeneration,which often results in clinical repair failure w...
关键词：Tendon regeneration Large-to-massive tendon defect Tendon tissue engineering Extracellular matrix Polyurethane 
Extracellular matrix stiffness as an energy metabolism regulator drives osteogenic differentiation in mesenchymal stem cells被引量：1
《Bioactive Materials》2024年第5期549-563,共15页Jing Na Zhijie Yang Qiusheng Shi Chiyu Li Yu Liu Yaxin Song Xinyang Li Lisha Zheng Yubo Fan 
supported by National Natural Science Foundation of China[grant numbers 32171310,11972067,U20A20390,11827803,12332019].
The biophysical factors of biomaterials such as their stiffness regulate stem cell differentiation.Energy metabolism has been revealed an essential role in stem cell lineage commitment.However,whether and how extracel...
关键词：Matrix stiffness Metabolic regulation YAP Stem cell fate Cellular mechanics 
Extracellular matrix-derived materials for tissue engineering and regenerative medicine:A journey from isolation to characterization and application被引量：1
《Bioactive Materials》2024年第4期494-519,共26页Helena Vilaça-Faria Jennifer Noro Rui L.Reis Rogério P.Pirraco 
the EU Horizon 2020 research and innovation programme under the ERC grant CapBed(805411);the contributions to this research from the project“TERM RES Hub-Scientific Infrastructure for Tissue Engineering and Regenerative Medicine”,reference PINFRA/22190/2016(Norte-01-0145-FEDER-022190);funded by the Portuguese National Science Foundation(FCT)in cooperation with the Northern Portugal Regional Coordination and Development Commission(CCDR-N),for providing relevant lab facilities,state-of-the art equipment and highly qualified human resources,the funding for the ICVS/3B’s Associate Laboratory(DOI:10.54499/UIDB/50026/2020,10.54499/UIDP/50026/2020,10.54499/LA/P/0050/2020).
Biomaterial choice is an essential step during the development tissue engineering and regenerative medicine(TERM)applications.The selected biomaterial must present properties allowing the physiological-like recapitula...
关键词：Extracted ECM Extraction methods CHARACTERIZATION ECM-derived applications 
Intraoperative bioprinting of human adipose-derived stem cells and extra-cellular matrix induces hair follicle-like downgrowths and adipose tissue formation during full-thickness craniomaxillofacial skin reconstruction
《Bioactive Materials》2024年第3期114-128,共15页Youngnam Kang Miji Yeo Irem Deniz Derman Dino JRavnic Yogendra Pratap Singh Mecit Altan Alioglu Yang Wu Jasson Makkar Ryan R.Driskell Ibrahim T.Ozbolat 
supported by National Institutes of Health Award R01DE028614,R56HL157190,R21AR082668,and R01AR078743,and 2236 CoCirculation2 of TUBITAK award 121C359.
Craniomaxillofacial(CMF)reconstruction is a challenging clinical dilemma.It often necessitates skin replacement in the form of autologous graft or flap surgery,which differ from one another based on hypodermal/dermal ...
关键词：Intraoperative bioprinting Adipose-derived extracellular matrix Adipose-derived stem cells Skin tissue engineering 
Alveolar macrophage phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis
《Bioactive Materials》2024年第3期262-278,共17页Woo Tak Lee Hyunjun Lee Juho Kim Yujin Jung Eojin Choi Ji Hoon Jeong Jee-Heon Jeong Jung Heon Lee Yu Seok Youn 
supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT;No.NRF-2019R1A5A2027340);by the Bio&Medical Technology Development Program of the NRF funded by the Korean government(MSIT,No.NRF-2022M3A9G8017220).
Idiopathic pulmonary fibrosis(IPF)is a chronic inflammatory and fibrotic response-driven lung disease that is difficult to cure because it manifests excessive profibrotic cytokines(e.g.,TGF-β),activated myofibroblast...
关键词：Aerosolizable microgel Lung retention Extracellular matrix Pro-inflammatory cytokines Idiopathic pulmonary fibrosis 
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