EXTRACELLULAR_MATRIX

作品数：418被引量：1435H指数：17
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相关作者：梁倩倩王拥军侯炜崔学军王坤杰更多>>
相关机构：四川大学华西医院上海中医药大学湖北中医药大学浙江衢化医院更多>>
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Neurocircuit regeneration by extracellular matrix reprogramming
《Neural Regeneration Research》2025年第8期2300-2301,共2页Shengzhang Su Ian N.Levasseur Kimberly M.Alonge 
supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA);National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA);Department of Defense(DoD)grant AZ210089(to KMA)。
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning...
关键词：MATRIX PROGRAMMING 
AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration
《中国组织工程研究》2025年第17期3537-3547,共11页Yu Yangyi Song Zhuoyue Lian Qiang Ding Kang Li Guangheng 
国家自然科学基金面上项目(81472136),项目负责人:李广恒。
BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene ma...
关键词：OSTEOARTHRITIS adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes. 
Engrailed-1 inactivation leads to scarless skin wound healing through extracellular matrix remodeling
《Genes & Diseases》2025年第3期64-67,共4页Ailing Hao Xiangyu Dong Yannian Gou Aohua Li Jiajia Li Han Xiang Saidur Rahaman Yi Zhu Hui Zhang Wulin You Guowei Shen Changqi Luo Ou Mei Xingye Wu Lewis L.Shi Russell R.Reid Tong-Chuan He Jiaming Fan 
supported in part by research grants from the Natural Science Foundation of China(No.82102696 to J.F.);the Chongqing Natural Science Foundation of China(No.2024NSCQ-MSX0073 to J.F.);the US National Institutes of Health(No.CA226303 to T.C.H.;DE030480 to R.R.R.).
Hypertrophic scar and keloid are a major medical problem,which may lead to disfigurement,growth restriction,and permanent loss of function,causing severe physical,psychological,and economic burdens.1 When skin injury ...
关键词：engrailed inactivation blood clottinggranulation tissue physiological eventsincluding scarless skin wound healing hypertrophic scar keloid extracellular matrix remodeling extracellular matrix skin injury 
Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration
《Neural Regeneration Research》2025年第5期1364-1376,共13页Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing 
supported by the Natio`nal Natural Science Foundation of China,No. 81801241;a grant from Sichuan Science and Technology Program,No. 2023NSFSC1578;Scientific Research Projects of Southwest Medical University,No. 2022ZD002 (all to JX)。
Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to p...
关键词：ALGINATE axon growth BIOMATERIALS extracellular matrix neural repair neurons NEUROREGENERATION POLYACRYLAMIDE POLYDIMETHYLSILOXANE stiffness 
Stem cell therapy for intervertebral disc degeneration:Clinical progress with exosomes and gene vectors
《World Journal of Stem Cells》2025年第4期20-35,共16页Zhi-Peng Li Han Li Yu-Hua Ruan Peng Wang Meng-Ting Zhu Wei-Ping Fu Rui-Bo Wang Xiao-Dong Tang Qi Zhang Sen-Li Li He Yin Cheng-Jin Li Yi-Gong Tian Rui-Ning Han Yao-Bin Wang Chang-Jiang Zhang 
Supported by Henan Province Key Research and Development Program,No.231111311000;Henan Provincial Science and Technology Research Project,No.232102310411;Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365;Henan Province Medical Education Research Project,No.WJLX2023079;and Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
Intervertebral disc degeneration is a leading cause of lower back pain and is characterized by pathological processes such as nucleus pulposus cell apoptosis,extracellular matrix imbalance,and annulus fibrosus rupture...
关键词：EXOSOMES Extracellular matrix repair Gene vector system Hypoxic environment Intervertebral disc degeneration Mesenchymal stem cells Regenerative medicine Stem cell therapy 
Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19
《International Journal of Ophthalmology(English edition)》2025年第2期322-322,共1页Jing Zhu Duy Nguyen Hong Ouyang Xiao-Hui Zhang Xiao-Ming Chen Kang Zhang 
We ourselves recently reviewed our article published in Int J Ophthalmol entitled“Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-βin ARPE-19”and would...
关键词：submit Ophthal matrix 
Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury:Insights from RNA sequencing for diagnosis and therapy
《World Journal of Gastrointestinal Surgery》2025年第2期25-36,共12页Dao-Jian Xu Guo-Tao Wang Qiang Zhong 
Supported by Health Science and Technology Programme of Zhejiang Province,No.2022KY1391.
Intestinal ischemia-reperfusion injury(IIRI)is a complex and severe pathophysiological process characterized by oxidative stress,inflammation,and apoptosis.In recent years,the critical roles of extracellular matrix(EC...
关键词：Diagnostic biomarkers Extracellular matrix Gene expression Intestinal ischemia-reperfusion injury Matrix metalloproteinases MICRORNA Treatment strategies 
Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model
《Hepatobiliary & Pancreatic Diseases International》2025年第1期92-103,共12页Kosar Nouri Abbas Piryaei Homeyra Seydi Ibrahim Zarkesh Ibrahim Ghoytasi Bahare Shokouhian Mustapha Najimi Massoud Vosough 
financially supported by grants from Royan In-stitute(grant No.400000200);Bahar Tashkhis Teb Co.(BTT,9703,9809,and 9903)。
Background: Despite considerable advancements in identifying factors contributing to the development of hepatocellular carcinoma(HCC), the pathogenesis of HCC remains unclear. In many cases, HCC is a consequence of pr...
关键词：Liver fibrosis Decellularized extracellular matrix SPHEROID Epithelial-to-mesenchymal transition Cell differentiation Hepatocellular carcinoma 
Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma
《Cancer Communications》2025年第2期110-137,共28页Peiyu Wang Guangxi Wang Haoran Li Yuyao Yuan Haiming Chen Shaodong Wang Zewen Sun Fanjie Meng Yun Li Fan Yang Jun Wang Kezhong Chen Mantang Qiu 
National Natural Science Foundation of China,Grant/Award Numbers:92059203,82173386;National Key R&D Program of China,Grant/Award Number:2023YFF0723500;Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer,Chinese Academy of Medical Sciences,Grant/Award Number:2021RU002;Medical and Health Science and Technology Innovation project,Grant/Award Number:2021-I2M-002;Beijing Nova Program,Grant/Award Number:20230484314;Innovation Fund for Excellent PhD student of Peking University Health Science Center,Grant/Award Number:2022-58。
Background:Recurrence and metastasis remain significant challenges in lung adenocarcinoma(LUAD)after radical resection.The mechanisms behind the recurrence and metastasis of LUAD remain elusive,and deregulated cellula...
关键词：Nicotinamide N-methyl transferase Lung cancer Cancer-associated fibroblast Extracellular matrix Metastasis 
Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix
《BIOCELL》2025年第1期109-125,共17页RENATA DA SILVA CARNEIRO MATEUS HENRIQUE DE ALMEIDA DA COSTA JOSÉZILTON LIMA VERDE SANTOS VALDILÉIA TEIXEIRA UCHÔA LUCIANO DA SILVA LOPES ANDERSON NOGUEIRA MENDES 
Anderson Nogueira Mendes(#302704/2023-0)is grateful to the public Brazilian agency“Conselho Nacional de Desenvolvimento Científico e Tecnológico”(CNPq)for their personal scholarships.
Neurodegenerative diseases are a major public health challenge,mainly affecting the elderly population and compromising their cognitive,sensory,and motor functions.Currently,available therapies focus on alleviating sy...
关键词：TERPENES Neurodegenerative Disorders Extracellular matrix 
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