supported by the National Natural Science Foundation of China(81573636,81773924);Beijing Natural Science Foundation(7182114);CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-1-004);the Fundamental Research Funds for the Central Universities(2018RC350010);Project of NDRC and State Administration of Traditional Chinese Medicine(ZYBZH-Y-HUN-24).
The endocannabinoid system(ECS)has received extensive attention for its neuroprotective effect on the brain.This system comprises endocannabinoids,endocannabinoid receptors,and the corresponding ligands and proteins.T...
Alzheimer’s disease(AD)is a widespread pathology described for the first time by Alois Alzheimer in 1907.It can be classified as a neurodegenerative disease consisting in a progressive loss of memory and cognitive fu...
Background:The goal of this study is to determine the expression and localization of the cannabinoid receptor type 1(CB1R),the synthesizing enzyme N-acyl phosphatidyl-ethanolamine phospholipase D(NAPE-PLD),and the deg...
Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors.These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol,the psych...
Background:The expression,localization,and function of the endocannabinoid system has been well characterized in recent years in the monkey retina and in the primary thalamic relay,the lateral geniculate nucleus(dLGN)...