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GENE_POLYMORPHISMS: 作品数：258被引量：907H指数：14; 导出分析报告; 相关作者：王增军王涛张炜李琼芳陈常中更多>>; 相关机构：江苏省人民医院甘肃省肿瘤医院第二军医大学重庆医科大学附属第一医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>

Association between Gene Polymorphisms and SNP-SNP Interactions of the Matrix Metalloproteinase 2 Signaling Pathway and the Risk of Vascular Senescence: 《Biomedical and Environmental Sciences》2024年第2期146-156,共11页LIAO Zhen Yu YANG Shuo HU Song LIU Jia MAO Yong Jun SUN Shu Qin; supported by the Construction of Prevention and Treatment System of Geriatric Syndromes Focusing on Disability and Dementia(No.21-1-2-2-zyyd-nsh)。; Objective This study aimed to explore the association of single nucleotide polymorphisms(SNP)in the matrix metalloproteinase 2(MMP-2)signaling pathway and the risk of vascular senescence(VS).Methods In this cross-sect...; 关键词：Vascular senescence Pulse wave velocity(PWV) Single nucleotide polymorphism(SNP) Matrix metalloproteinase 2(MMP-2) Extracellular matrix(ECM) Structural degradation Multifactor dimensionality reduction(MDR)

NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss被引量：1: 《Biomedical and Environmental Sciences》2021年第9期705-718,共14页LIU Shuang Yan SONG Wei Qin XIN Jia Rui LI Zheng LEI Song CHEN Ying Qi ZHAO Tian Yu WANG Hai Yan XU Liang Wen ZHANG Mei Bian HONG Yu YANG Lei; supported by Zhejiang Key Research and Development Program of China[No.2015C03039,No.20152013A01];Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents,China;Zhejiang Health Innovative Talent Training Project of China;general scientific research project of Zhejiang Science and Technology Department of China[No.Y201941671];Natural Science Foundation of Zhejiang Provincial,China[LY18H260002]。; Objective The effects of interactions between genetic and environmental factors on the noise-induced hearing loss(NIHL)are still unclear.This study aimed to assess interactions among gene polymorphisms,noise metrics,a...; 关键词：Noise-induced hearing loss KURTOSIS CAT NRN1 LIFESTYLE Interaction Generalized multifactor dimensionality reduction

Interaction Effects of Gene Polymorphisms and Obesity on Nonalcoholic Fatty Liver Disease: 《Biomedical and Environmental Sciences》2019年第10期793-796,共4页SUN Xiao Ya HE Zhi Qiang WANG Li Qun WANG Zhi Zhong BAI Fei Hu YOU Yan Jie; supported by the Top Discipline of Public Health and Prevent Medicine [NXYLXK2017B08],Education Department of Ningxia,China; Nonalcoholic fatty liver disease(NAFLD)is a common chronic condition that affects adults and has a global prevalence of 25%[1],with the prevalence being 31%among the general population in China[2].A meta-analysis of s...; 关键词：NAFLD OBESITY PREVALENCE

Association between NFE2L2 Gene Polymorphisms and Noise-induced Hearing Loss in a Chinese Population被引量：2: 《Biomedical and Environmental Sciences》2019年第6期465-470,共6页WANG Bo Shen XU Kai ZHANG Hong PU Yue Pu YIN Li Hong HAN Lei CHEN Lin WANG Ning ZHU Bao Li ZHANG Juan; supported by Outstanding Medical Academic Leaders program of Jiangsu Province [LJ201130];Jiangsu Provincial Youth Medical Talent program [QNRC2016536];Six Talent Peaks Project in Jiangsu Province [WSW-017];Preventive Medicine Foundation of Jiangsu [Y2015049];The Fundamental Research Funds for the Central Universities [3225009404]; Occupatio nal n oise is among the most comm on risks associated with the wellbeing of employees. Occupational exposure to noise causes disabling hearing loss in 16% of adults worldwide.It has bee n ack no wledged that...; 关键词：NFE2L2 GENE POLYMORPHISMS CHINESE POPULATION

Interleukin 8 Gene Polymorphisms Are Not Associated with Tuberculosis Susceptibility in the Chinese Population被引量：4: 《Biomedical and Environmental Sciences》2016年第2期158-161,共4页MA Yan LIU Yu Hong ZHANG Zhi Guo WANG Li YANG Xiao Wei LI Chuan You CHE Nan Ying; supported by grants from the National Natural Science Foundation of China(Grant Number:81572077);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special(Grant Number:XMLS201506);Beijing Health System Training Program for High Level Technique Talents(Grant Number:2014-3-082);the Capital Health Research and Development of Special(Grant Number:2014-4-2161); Interleukin 8 （IL8） is an important chemokine that elicits host immune response against tuberculosis （TB）. However, whether there is an association between IL8 gene polymorphism and TB susceptibility in the Chines...; 关键词：TB FIGURE

BHMT Gene Polymorphisms as Risk Factors for Cleft Lip and Cleft Palate in a Chinese Population被引量：3: 《Biomedical and Environmental Sciences》2011年第2期89-93,共5页HU Ying CHEN ErJun MU Yue LI JinLu CHEN RenJi; supported by the National Natural Science Foundation of China (grant number 307009907);Beijing Natural Science Foundation (grant number 7082038);Beijing Foundation for Excellent Elite (grant number 2010D003034000013); Objective Convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate （NSCL/P） and low intake of folic acid by the mother during pregnancy. The present study was...; 关键词：Nonsyndromic cleft lip with or without palate HOMOCYSTEINE Folate POLYMORPHISMS

Association of TNF-α-238G/A and 308 G/A Gene Polymorphisms with Pulmonary Tuberculosis among Patients with Coal Worker’s Pneumoconiosis被引量：12: 《Biomedical and Environmental Sciences》2010年第2期137-145,共9页HONG-MIN FAN ZHUO WANG FU-MIN FENG KONG-LAI ZHANG JU-XIANG YUAN HONG SUI HONG-YAN QIU LI-HUA LIU XIAO-JUAN DENG JING-XUE REN; supported by grants from China National Programs for Science and Technology Development (Grant No. 2003BA712A11-24);Scientific Research Fund of North China Coal Medical College (Grant No. 2005-14); Objectives Tumor necrosis factor-α （TNF-α） may play an important role in host＇s immune response to mycobacterium tuberculosis （M. tuberculosis） infection. This study was to investigate the association of TNF-α...; 关键词：Coal worker＇s pneumoeoniosis （CWP） Pulmonary tuberculosis （TB） Susceptibility POLYMORPHISM Tumor necrosis factor （TNF） α-308 α-238 Polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） Interaction

Plasma Homocysteine and Gene Polymorphisms Associated with the Risk of Hyperlipidemia in Northern Chinese Subjects被引量：14: 《Biomedical and Environmental Sciences》2008年第6期514-520,共7页LEI HUANG XIAO-MING SONG WEN-LI ZHU YONG LI; supported by Beijing Natural Science Foundation, China (No. 7072044).; Objective To examine the relationship between occurrence of hyperlipidemia, plasma homocysteine and polymorphisms of methylenetetra hydrofolate reductase （MTHFR） gene and methionine synthase （MS） gene. Methods A t...; 关键词：Methylenetetra hydrofolate reductase Methionine synthase Gene polymorphism HOMOCYSTEINE HYPERLIPIDEMIA

Interactions Between Effects of Estrogen Receptor Gene Polymorphisms on BMD and Experiences of the First Spermorrhea in Chinese Han Boys被引量：2: 《Biomedical and Environmental Sciences》2008年第2期129-136,共8页JING YIN QIAN ZHANG XIAO-QI HU WEI-JING DU AI-LING LIU XIAO-YAN WANG ZHI-QIN TONG GUAN-SHENG MA; The research was supported and financed by National Natural Science Foundation of China (No. 30471453); Objective To study the interaction between polymorphisms of estrogen receptor （ER） gene and puberty on bone mineral density （BMD）. Methods One hundred and forty-six boys aged 13-17 years were divided into two grou...; 关键词：BMD Puberty Hormones and receptors POLYMORPHISM BOYS

Association of the Apolipoprotein B Gene Polymorphisms With Essential Hypertension in Northern Chinese Han Population被引量：4: 《Biomedical and Environmental Sciences》2007年第3期260-264,共5页WEI-YAN ZHAO JIAN-FENG HUANG LAI-YUAN WANG HONG-FAN LI PENG-HUA ZHANG QI ZHAO SHU-FENG CHEN DONG-FENG GU; This work was funded by the National Basic Research Program of China (No. 2006CB503805);the Ministry of Science and Technology of The People’s Republic of China (No.2006AA02Z170,2006AA020706);Beijing Natural Science Foundation (No.7061006).; Objective To study the association of the apolipoprotein B gene polymorphisms with essential hypertension in Northern Chinese Han population. Methods XbaI and EcoRl polymorphisms of the apolipoprotein B （APOB） gene ...; 关键词：Essential hypertension APOB gene POLYMORPHISMS Case-control study

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