GENOMIC

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Comparison of genomic and transcriptional microbiome analysis in gastric cancer patients and healthy individuals被引量：2
《World Journal of Gastroenterology》2023年第7期1202-1218,共17页Darja Nikitina Konrad Lehr Ramiro Vilchez-Vargas Laimas Virginijus Jonaitis Mindaugas Urba Juozas Kupcinskas Jurgita Skieceviciene Alexander Link 
the MULTIOMICS project that has received funding from European Social Fund(No.09.3.3-LMT-K-712-010130)under grant agreement with the Research Council of Lithuania;the“LiLife”project as part of the“Autonomy in old Age”research group(No.ZS/2018/11/95324)under grant agreement with European Commission through the“European Funds for Regional development”.
BACKGROUND Helicobacter pylori and the stomach microbiome play a crucial role in gastric carcinogenesis,and detailed characterization of the microbiome is necessary for a better understanding of the pathophysiology of...
关键词：Gastric cancer MICROBIOME Helicobacter pylori 16S rRNA gene 16S rRNA transcript 16S rDNA 
Similarities,differences,and possible interactions between hepatitis E and hepatitis C viruses:Relevance for research and clinical practice被引量：1
《World Journal of Gastroenterology》2022年第12期1226-1238,共13页Nadia Marascio Salvatore Rotundo Angela Quirino Giovanni Matera Maria Carla Liberto Chiara Costa Alessandro Russo Enrico Maria Trecarichi Carlo Torti 
Supported by PON Research and Innovation 2014-2020(Nadia Marascio),Attraction and International Mobility programme;No.Proposal Code_Activity AIM1879147_1。
Hepatitis E virus(HEV)and hepatitis C virus(HCV)are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic manifestations.Hepatitis E is usually a viral acute fecal-oral transmitted ...
关键词：Hepatitis C virus Hepatitis E virus CO-INFECTION Genomic variability Extrahepatic diseases VACCINE 
Molecular advances in pancreatic cancer:A genomic,proteomic and metabolomic approach
《World Journal of Gastroenterology》2021年第31期5171-5180,共10页Srujan Rajesh Michael J Cox Franscois Runau 
Pancreatic ductal adenocarcinoma(PDAC)represents a challenging pathology with very poor outcomes and is increasing in incidence within the general population.The majority of patients are diagnosed incidentally with in...
关键词：Pancreatic ductal adenocarcinoma Pancreatic adenocarcinoma GENOMIC PROTEOMIC METABOLOMIC 
Origin and genomic characteristics of SARS-CoV-2 and its interaction with angiotensin converting enzyme type 2 receptors, focusing on the gastrointestinal tract被引量：3
《World Journal of Gastroenterology》2020年第41期6335-6345,共11页Michail Galanopoulos Aris Doukatas Maria Gazouli 
The emergence of coronavirus disease-2019 induced by a newly identified bcoronavirus, namely severe acute respiratory syndrome coronavirus 2(SARSCoV-2) has constituted a public health emergency. Even though it was con...
关键词：SARS-CoV-2 COVID-19 Gastrointestinal tract Angiotensin converting enzyme type 2 Angiotensin converting enzyme type 2 receptor Renin-angiotensin system Angiotensin converting enzyme 
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies被引量：2
《World Journal of Gastroenterology》2020年第11期1197-1207,共11页Ioannis A Voutsadakis 
BACKGROUND BRIP1 is a helicase that partners with BRCA1 in the homologous recombination(HR) step in the repair of DNA inter-strand cross-link lesions. It is a rare cause of hereditary ovarian cancer in patients with n...
关键词：BRIP1 FANCJ BACH1 GASTROINTESTINAL CANCERS MUTATIONS COPY number alterations 
Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis被引量：7
《World Journal of Gastroenterology》2019年第26期3408-3425,共18页Jing-Bo Wu Ali Lopez Sarmiento Pierre-Olivier Fiset Anthula Lazaris Peter Metrakos Stephanie Petrillo Zu-Hua Gao 
the Human Resources Development Program for the Outstanding Talents in The Fifth People’s Hospital of Shanghai,Fudan University,No.2017WYRCJY09;the Key Medical Speciality of The Fifth People’s Hospital of Shanghai,Fudan University,No.2017WY202K08
BACKGROUND Different histological growth patterns(HGPs)of colorectal carcinoma(CRC)liver metastasis are associated with patients’prognosis and response to antiangiogenic therapy.However,the relationship between HGPs ...
关键词：COLORECTAL carcinoma Liver metastasis HISTOLOGIC growth pattern CLINICOPATHOLOGICAL characteristics Whole EXOME SEQUENCING 
Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations被引量：11
《World Journal of Gastroenterology》2019年第20期2489-2502,共14页Hui-Hong Jiang Zhi-Yong Zhang Xiao-Yan Wang Xuan Tang Hai-Long Liu Ai-Li Wang Hua-Guang Li Er-Jiang Tang Mou-Bin Lin 
the National Natural Science Foundation of China,No.81874201;Shanghai Municipal Commission of Health and Family Planning,No.ZK2015A32 and No.201840359
BACKGROUND Lymphovascular invasion (LVI) is suggested to be an early and important step in tumor progression toward metastasis, but its prognostic value and genetic mechanisms in colorectal cancer (CRC) have not been ...
关键词：COLORECTAL cancer Lymphovascular INVASION PROGNOSTIC DNA COPY number ABERRATION Functional analysis 
New prognostic biomarkers of mortality in patients undergoing liver transplantation for hepatocellular carcinoma被引量：8
《World Journal of Gastroenterology》2018年第37期4230-4242,共13页Leonardo Lorente 
The outcome prediction of hepatocellular carcinoma(HCC) patients undergoing liver transplantation(LT) was classically established using various macromorphological factors and serum alpha-fetoprotein levels prior to LT...
关键词：Liver TRANSPLANTATION HEPATOCELLULAR carcinoma Biomarkers OUTCOME Survival RECURRENCE GENOMIC 
Analysis of 12 variants in the development of gastric and colorectal cancers
《World Journal of Gastroenterology》2017年第48期8533-8543,共11页Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes Danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos 
Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq);Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES);Pró-Reitoria de Pesquisa e Pós-Graduacao da Universidade Federal do Pará/Fundacao Amparo e Desenvolvimento da Pesquisa(PROPESP-UFPA/FADESP)
AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC di...
关键词：Inflammatory processes Immune response Genomic and cellular stability Gastric cancer Colorectal cancer AMAZON 
Genomic diversity of colorectal cancer: Changing landscape and emerging targets
《World Journal of Gastroenterology》2016年第25期5668-5677,共10页Daniel H Ahn Kristen K Ciombor Sameh Mikhail Tanios Bekaii-Saab 
Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers(CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high propor...
关键词：COLORECTAL cancer KRAS MUTATION BRAF MUTATION GENOMIC diversity Tumor DNA 
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