INFLAMMATORY

作品数:1343被引量:5270H指数:26
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相关领域:医药卫生更多>>
相关作者:王国春卢昕戚晓昆邹忠东王兴鹏更多>>
相关机构:中日友好医院北京协和医院复旦大学温州医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金湖北省自然科学基金更多>>
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Intracellular codelivery of anti-inflammatory drug and anti-miR 155 to treat inflammatory disease被引量:14
《Acta Pharmaceutica Sinica B》2020年第8期1521-1533,共13页Chao Teng Chenshi Lin Feifei Huang Xuyang Xing Shenyu Chen Ling Ye Helena S.Azevedo Chenjie Xu Zhengfeng Wu Zhongjian Chen Wei He 
supported by the National Natural Science Foundation of China(Nos.81872823 and 81773826);the Double First-Class(CPU2018PZQ13,China)of the China Pharmeutical University;the Ministry of Science and Technology of China(2018ZX09711001);the Shanghai Science and Technology Committee(19430741500,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of traditional Chinese Medicine(TCM201905,China)
Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery o...
关键词:miR155 INFLAMMATORY SUSTAINED 
Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models被引量:40
《Cellular & Molecular Immunology》2019年第12期908-920,共13页Yanhong Li Di Zhang Ling Xu Lin Dong Ji Zheng Yikong Lin Jiefang Huang Yanyun Zhang Yu Tao Xingxing Zang Dajin Li Meirong Du 
supported by the National Basic Research Program of China(2015CB943300 and 2017YFC1001403);the Nature Science Foundation from the National Nature Science Foundation of China(NSFC)(81630036,91542116,31570920,81490744,31171437,31270969,81571512,and 81501334);the Innovation-oriented Science and Technology Grant from the NHC Key Laboratory of Reproduction Regulation(CX2017-2);the Program of Shanghai Academic/Technology Research Leader(17XD1400900);the Key Project of Shanghai Municipal Education Commission(MECSM)(14ZZ013);the Key Project of Shanghai Basic Research from Shanghai Municipal Science and Technology Commission(STCSM)(12JC1401600).
Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanaval...
关键词:INFLAMMATORY effect thereby 
Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats被引量:13
《World Journal of Gastroenterology》2017年第34期6220-6230,共11页Zhi-Yuan Li Yan Huang Yan-Ting Yang Dan Zhang Yan Zhao Jue Hong Jie Liu Li-Jie Wu Cui-Hong Zhang Huan-Gan Wu Ji Zhang Xiao-Peng Ma 
Supported by National Natural Science Foundation of China,No.81273843 and No.81674073;National Key Basic Research Program of China(973 Program);No.2015CB554501;Project of Shanghai Municipal Commission of Health and Family Planning,No.20144Y0153 and No.2017BR047
AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response...
关键词:Herb-partitioned moxibustion Chronic inflammatory visceral pain Pain behavior ANALGESIA MEK Extracellular signal-regulated kinase c AMP response element binding protein Signaling pathway 
Pro-inflammatory effects of a litchi protein extract in murine RAW264.7 macrophages被引量:2
《Horticulture Research》2016年第1期219-225,共7页Xiaoli Wang Xiaorong Hu Huiqing Yan Zhaocheng Ma Xiuxin Deng 
This work was supported by the Special Fund for Agro-scientific Research in the Public Interest(No.201403036);the Fundamental Research Funds for the Central Universities(2014PY030);the National Basic Research Program of China(2011CB100600);the National NSF of China and the Foundation for the Key Program of the Ministry of Education,China(311029).
It has been observed that the consumption of litchi often causes symptoms characterized by itching or sore throat,gum swelling,oral cavity ulcers and even fever and inflammation,which significantly impair the quality ...
关键词:RAW264.7 INFLAMMATORY INFLAMMATION 
The progress in optic nerve regeneration, where are we?被引量:4
《Neural Regeneration Research》2016年第1期32-36,共5页Jennifer Wei Huen Shum Kai Liu Kwok-fai So 
supported by National Program on Key Basic Research Project of China(973 Program;2011CB707501);Funds of Leading Talents of Guangdong(2013);Program of Introducing Talents of Discipline to Universities(B14036)
Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are ma...
关键词:optic nerve regeneration axonal regeneration neurotrophic factor inflammatory stimulation nerve bridging substances 
The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis被引量:3
《Genes & Diseases》2014年第1期106-112,共7页Yaxi Chen Zac Varghese Xiong Z.Ruan 
This study was supported by Major State Basic Research Development Program of China(973 Program,NO.2012CB517700&2012CB517500);the National Natural Science Foundation of China(81270493,81270789,81200567 and Key Program,No.81030008,81390354);the Moorhead Trust,the Royal Free Hospital Special Trustees Grant-115 through Dr.Zac Varghese,and Kidney Research UK(RP37/2008).
Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression ...
关键词:Ectopic lipid deposition Inflammation Lipid homeostasis Lipid redistribution Non-alcoholic fatty liver disease 
Establishing a cancer cell in the inflammatory tissue: an epigenetic circuit
《Acta Biochimica et Biophysica Sinica》2012年第4期279-280,共2页Wenjing Mu Lijian Hui 
We would like to thank Latifa Bakiri, Xianghuo He, and Zhixin Qiu for critical reading of the manuscript. Work in Lijian Hui laboratory is partly funded by National Basic Research Program of China (2012CB945001), National Natural Science Foundation of China (31071238), and Chinese Academy of Sciences (the Hundred Talents Program).
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Risk factors, such as viral infec- tion, aflatoxin intake, and alcohol abuse, induce frequent hepatic cell death and chronic liver patholo...
Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination被引量:1
《Neural Regeneration Research》2011年第29期2267-2272,共6页Boting Gao Juan Chen Qiong Wang Wei Wang Zhouping Tang 
the Natural Science Foundation of Ministry of Science and Technology of China,No.30230140;a grant from Merck Serono (China)
The present study established a chronic experimental autoimmune encephalomyelitis model in C57BL/6 mice induced by myelin oligodendrocyte glycoprotein peptides and complete Freund's adjuvant. Onset latency was 12 day...
关键词:AXON C57BL/6 mouse experimental autoimmune encephalomyelitis myelin oligodendrocyte glycoprotein myelin sheath NEUROPATHOLOGY neural regeneration 
TRAIL receptor mediates inflammatory cytokine release in an NF-κB-dependent manner被引量:14
《Cell Research》2009年第6期758-767,共10页Wanhu Tang Weimin Wang Yaxi Zhang Shilian Liu Yanxin Liu Dexian Zheng 
We thank Drs Hongbing Shu (Wuhan University, China), Jiandong Li (University of Rochester Medical Center, USA), Andrew Thorbum (University of Colorado Comprehensive Cancer Center, USA) and Andreas Strasser (The Walter and Eliza Hall Institute of Medical Research, Australia) for the generous gifts of the constructs. This work was partially supported by the National Natural Science Foundation of China (Grants 30571687 and 30721063) and the State Key Basic Research Program of China (Grant 2007CB507404).
In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-α, CCL20, MIP-2 and MIP-1β in an NF-κB-dependent manner in 293T, MDA-MB-23...
关键词:TRAIL receptor INFLAMMATION CYTOKINE NF-ΚB 
黄芩抗内毒素组分的制备及其生物学活性研究被引量:4
《微循环学杂志》2008年第1期20-23,27,共5页伏建峰 曹红卫 王宁 刘鑫 杨东 鲁永玲 郑江 
国家重点基础研究发展计划资助项目(2005CB22600)
目的:研究从黄芩中分离提取拮抗内毒素(LPS)组分的制备方法及其生物学活性。方法:采用大孔吸附树脂AB-8将黄芩水提物分离成若干组分,应用生物传感器技术检测各组分与LPS的活性中心LipidA的结合活性,ELISA法检测各组分对LPS刺激RAW264.7...
关键词:抗内毒素 生物学活性 INFLAMMATORY 全身性炎症反应综合征 多器官功能障碍综合症 制备 组分 黄芩 
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