supported by the National Natural Science Foundation of China(Nos.81872823 and 81773826);the Double First-Class(CPU2018PZQ13,China)of the China Pharmeutical University;the Ministry of Science and Technology of China(2018ZX09711001);the Shanghai Science and Technology Committee(19430741500,China);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of traditional Chinese Medicine(TCM201905,China)
Atherosclerosis(AS) is a lipid-driven chronic inflammatory disease occurring at the arterial subendothelial space. Macrophages play a critical role in the initiation and development of AS. Herein,targeted codelivery o...
supported by the National Basic Research Program of China(2015CB943300 and 2017YFC1001403);the Nature Science Foundation from the National Nature Science Foundation of China(NSFC)(81630036,91542116,31570920,81490744,31171437,31270969,81571512,and 81501334);the Innovation-oriented Science and Technology Grant from the NHC Key Laboratory of Reproduction Regulation(CX2017-2);the Program of Shanghai Academic/Technology Research Leader(17XD1400900);the Key Project of Shanghai Municipal Education Commission(MECSM)(14ZZ013);the Key Project of Shanghai Basic Research from Shanghai Municipal Science and Technology Commission(STCSM)(12JC1401600).
Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanaval...
Supported by National Natural Science Foundation of China,No.81273843 and No.81674073;National Key Basic Research Program of China(973 Program);No.2015CB554501;Project of Shanghai Municipal Commission of Health and Family Planning,No.20144Y0153 and No.2017BR047
AIM To investigate the effects of herb-partitioned moxibustion(HPM) on phosphorylation of mitogen-activated extracellular signal-regulated kinase(MEK)1, extracellular signal-regulated kinase(ERK)1/2 and c AMP response...
This work was supported by the Special Fund for Agro-scientific Research in the Public Interest(No.201403036);the Fundamental Research Funds for the Central Universities(2014PY030);the National Basic Research Program of China(2011CB100600);the National NSF of China and the Foundation for the Key Program of the Ministry of Education,China(311029).
It has been observed that the consumption of litchi often causes symptoms characterized by itching or sore throat,gum swelling,oral cavity ulcers and even fever and inflammation,which significantly impair the quality ...
supported by National Program on Key Basic Research Project of China(973 Program;2011CB707501);Funds of Leading Talents of Guangdong(2013);Program of Introducing Talents of Discipline to Universities(B14036)
Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are ma...
This study was supported by Major State Basic Research Development Program of China(973 Program,NO.2012CB517700&2012CB517500);the National Natural Science Foundation of China(81270493,81270789,81200567 and Key Program,No.81030008,81390354);the Moorhead Trust,the Royal Free Hospital Special Trustees Grant-115 through Dr.Zac Varghese,and Kidney Research UK(RP37/2008).
Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression ...
We would like to thank Latifa Bakiri, Xianghuo He, and Zhixin Qiu for critical reading of the manuscript. Work in Lijian Hui laboratory is partly funded by National Basic Research Program of China (2012CB945001), National Natural Science Foundation of China (31071238), and Chinese Academy of Sciences (the Hundred Talents Program).
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Risk factors, such as viral infec- tion, aflatoxin intake, and alcohol abuse, induce frequent hepatic cell death and chronic liver patholo...
the Natural Science Foundation of Ministry of Science and Technology of China,No.30230140;a grant from Merck Serono (China)
The present study established a chronic experimental autoimmune encephalomyelitis model in C57BL/6 mice induced by myelin oligodendrocyte glycoprotein peptides and complete Freund's adjuvant. Onset latency was 12 day...
We thank Drs Hongbing Shu (Wuhan University, China), Jiandong Li (University of Rochester Medical Center, USA), Andrew Thorbum (University of Colorado Comprehensive Cancer Center, USA) and Andreas Strasser (The Walter and Eliza Hall Institute of Medical Research, Australia) for the generous gifts of the constructs. This work was partially supported by the National Natural Science Foundation of China (Grants 30571687 and 30721063) and the State Key Basic Research Program of China (Grant 2007CB507404).
In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-α, CCL20, MIP-2 and MIP-1β in an NF-κB-dependent manner in 293T, MDA-MB-23...