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作品数：1145被引量：4983H指数：24
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相关领域：医药卫生生物学更多>>
相关作者：梁世凯何瑞荣李建磊韩维奇石继红更多>>
相关机构：第二军医大学浙江省人民医院温州医科大学哈尔滨医科大学更多>>
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Diarylpentanoid,a curcumin analog,inhibits malignant meningioma growth in both in vitro and in vivo models
《World Journal of Experimental Medicine》2025年第2期171-184,共14页Anna Terasawa Kazuhiro Shimazu Hiroshi Nanjo Masatomo Miura Hiroyuki Shibata 
Supported by TAIHO Pharmaceutical,No.AS2023A000122715;Nippon Kayaku,No.NKCS20230416001.
BACKGROUND Malignant meningioma metastasizes systemically,primarily due to its role in epithelial-mesenchymal transition.Although the prognosis is extremely poor,drug development efforts have been limited,because this...
关键词：Malignant meningioma CURCUMIN Diarylpentanoid curcumin analog Hepatocellular growth factor Nuclear factor kappa B N-CADHERIN 
Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis
《World Journal of Stem Cells》2025年第4期113-135,共23页Ling-Qiang Chen Sha Ma Juan Yu Da-Chen Zuo Zi-Jing Yin Fa-You Li Xia He Hai-Ting Peng Xiao-Qing Shi Wei-Juan Huang Qin Li Jing Wang 
Supported by Basic Research Plan of Yunnan Province,No.202201AT070059;National Natural Science Foundation of China,No.81760407;Science and Technology Talent and Platform Plan of Yunnan Provincial Department of Science and Technology,No.202205AC160066.
BACKGROUND There is currently no effective treatment for osteoarthritis(OA),which is the most common joint disorder leading to disability.Although human umbilical cord mesenchymal stem cells(hUC-MSCs)are promising OA ...
关键词：OSTEOARTHRITIS Human umbilical cord mesenchymal stem cells EXOSOMES MiR-199a-3p Mitogen-activated protein kinase 4 Nuclear factor-kappaB 
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
《World Journal of Diabetes》2025年第4期189-204,共16页Ying Yang Yi Chen Jian-Ying Tang Jian Chen Gui-Qing Li Bing Feng Jiao Mu 
Supported by the Chongqing Basic Research and Frontier Exploration Project,No.cstc2018jcyjAX0834.
BACKGROUND At present,the incidence of diabetic nephropathy is increasing year by year,and there are many studies on the pathogenesis of diabetic nephropathy,but it is still not completely clear.The final pathological...
关键词：Diabetic kidney disease Mir-29a-3p DNA methylation Janus kinase/signal transducer and activator of transcription WNT/Β-CATENIN Renal fibrosis 
Bacterial indole-3-propionic acid inhibits macrophage IL-1βproduction through targeting methionine metabolism
《Science China(Life Sciences)》2025年第4期1118-1131,共14页Ziyi Han Jian Fu Aiyan Gong Wenkai Ren 
supported by the National Natural Science Foundation of China(32225047,U22A20510);Double First-Class Discipline Promotion Project(2023B10564001);National Center of Technology Innovation for Pigs(NCTIP-XD/B13);the Open Project Program of Sichuan Provincial Key Laboratory of Animal Disease-resistant Nutrition,Sichuan Agricultural University(SZ202301-02)。
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites,like indole derivatives from tryptophan.However,the direct role of these indole derivatives in macrophag...
关键词：IPA MACROPHAGE MAT2A IL-1Β 
STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer
《Acta Pharmacologica Sinica》2025年第4期1097-1110,共14页Jun Wang Hui-min Zhang Guan-hua Zhu Li-li Zhao Ji Shi Zhou-tong Dai Jia-peng Li Xing-rui Li Fan Sun Yuan Wu Shao-yong Chen Han-ning Li Xing-hua Liao Yuan Xiang 
financially supported by the National Natural Science Foundation of China(32170578 and 82203497);Hubei Natural Science Foundation(2024AFB905 and 2024AFD011);Hubei Province Key R&D Program(2022BCA007);Department of Education Scientific Research Program guidance project(B2023014);“The 14th Five Year Plan”Hubei Provincial advantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(2023C0303);Natural Science Foundation Exploration Program of Wuhan(2024040801020310);the Hunan Natural Science Foundation(2023JJ50310 and 2023JJ50296).
Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer(TNBC)in clinic.However,it has been perplexed by paclitaxel resistance in TNBC patients,resulting in a poor prognosis.Abnormal...
关键词：triple-negative breast cancer PACLITAXEL CD24 N-GLYCOSYLATION ferroptosis STT3 
Centromere protein A knockdown inhibits rectal cancer through O6- methylguanine DNA methyltransferase/protein tyrosine phosphatase nonreceptor type 4 axis
《World Journal of Gastrointestinal Oncology》2025年第4期347-364,共18页Ming-Jie Xin Yong Yuan 
This study was reviewed and approved by the Ethic Committee of Medical College of Henan Vocational University of Science and Technology(Approval No.HVUYL414101416920231017001);all participants signed a written informed consent.
BACKGROUND Centromere protein A(CENPA)exhibits an increased expression level in primary human rectal cancer tissues,but its role has not been investigated.AIM To clarify the specific role and mechanism of CENPA in rec...
关键词：Rectal cancer Centromere protein A O6-methylguanine DNA methyltransferase Protein tyrosine phosphatase nonreceptor type 4 PROLIFERATION INVASION 
Nitric oxide synthase 1 inhibits the progression of esophageal cancer through interacting with nitric oxide synthase 1 adaptor protein
《World Journal of Gastrointestinal Oncology》2025年第4期427-441,共15页Zi-Wei Xiao Ying-Chao Zeng Lin-Tao Ji Jia-Tao Yuan Lin Li 
Supported by the National Natural Science Foundation of China,No.81000201.
BACKGROUND Esophageal cancer(ESCA)is among the most prevalent and lethal tumors globally.While nitric oxide synthase 1(NOS1)is recognized for its important in-volvement in various cancers,its specific function in ESCA...
关键词：Nitric oxide synthase 1 Nitric oxide synthase 1 adaptor protein AUTOPHAGY Phosphatidylinositol 3-kinase/protein kinase B pathway Esophageal cancer 
Targeting Syntaxin 1A via RNA interference inhibits feeding and midgut development in Locusta migratoria
《Insect Science》2025年第2期385-397,共13页Xiaojian Liu Ya Gao Yao Li Jianzhen Zhang 
supported by the National Key R&D Program of China(2022YFD1700200);the Natural Science Foundation of Shanxi Province,China(20210302123440);the Fund for Shanxi“1331 Project”and the Graduate Education Innovation Project of Shanxi Province,China(2023SJ033).
Syntaxin 1A(Syx1A)has diverse and indispensable functions in animals.Pre-vious studies have mainly focused on the roles of Syx1A in Drosophila,and so how Syx1A operates during the development of other insects remains ...
关键词：insulin/mTOR pathway Locusta migratoria midgut development RNAi Syntaxin 1A 
Ferroptosis Inducer RSL3 Inhibits Cell Death by Camptothecin-Induced Apoptosis
《Journal of Biophysical Chemistry》2025年第1期1-13,共13页Koichi Sakurai Aira Koguma Nanako Akita Takeru Miyamoto Aya Fukura Sanae Muraoka Hirayama 
Ferroptosis, an iron-dependent type of cell death, is being considered for new clinical treatments of malignant tumors that are difficult to treat with apoptosis inducers. Although several reports have attempted to in...
关键词：Apoptosis Cell Viability DNA Laddering Ferroptosis Iron PEROXIDE 
Epibrassinolide Induces Apoptosis and Inhibits the Migration of Gastric Cancer AGS Cells by Regulating Reactive Oxygen Species-Mediated Signaling Pathways
《BIOCELL》2025年第3期465-482,共18页Chang Wang Zhi Zhang Wei Sun Quan Quan Wenshuang Hou Chenghao Jin 
supported by the Heilongjiang Province Key Research and Development Plan Guidance Project[Grant No.GZ20220039];the Central Government Supports the Local College Reform and Development Fund Talent Training Project[Grant No.2020GSP16].
Objectives:Epibrassinolide(EBR)is a steroid hormone with anti-tumor properties.Nevertheless,its potential to inhibit gastric cancer(GC)cells remains unknown.The aim of this research was to examine the effects of EBR o...
关键词：EPIBRASSINOLIDE gastric cancer cell apoptosis cell cycle cell migration 
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