supported by a grant from the Health Research New Zealand(HRC)22/559(to AJG and LB)。
Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability.Detailed asse...
Traumatic injuries to the central nervous system(CNS) result in disruption of the intricate network of axons which connect functionally related neurons that are widely distributed throughout the brain and spinal cord....
partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (15K06723;18K07380);the Japan Agency for Medical Research and Development (AMED) (21nk0101538h0002) (to TN)。
Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem...
The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and communication.Consequently,injuries or diseases of the CNS are often a...
supported in part by National Institutes of Health grants,R01AR068279(NIAMS),STTR R42EY031196(NEI),and STTR 1R41AG057242(NIA)(to HD).
Neurological disorders and injuries lead to the impairment or depletion of neurons in terms of quantity,structure,or function,resulting in the loss of cognitive,emotional,and physical abilities in human beings.This,in...
supported by A*STAR Career Development Fund (C210112011);National Medical Research Council (MOH-001248-00)(to WHC);Singapore International Graduate Award (to YW);National Research Foundation (NRFNRFF-2018-003);Biomedical Research Council,A*STAR Research Entities (to SYN)
Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing properties.When exposed to the right combinations o...
supported in part by the R21AG077643,R01NS123571,1U19NS130607,and 5T U24 HG012070(to GZ);in part by Alzheimer Association Fellowship Award 23AARFD-1029969(to IOS).
Astrocytes are a major glial cell type in the central nervous system,and they provide trophic and metabolic support to neurons.In addition to these roles,they play crucial roles in modulating synaptic functions,develo...
supported by the Royal Thai Government Scholarship(to PM).
Peripheral nerves are essential components of the human body’s communication system,transmitting signals between the central nervous system and various body parts.Damage resulting from trauma or disease can result in...
supported by the National Natural Science Foundation of China,No.82101461(to ZL)。
Central nervous system injuries have a high rate of resulting in disability and mortality;however,at present,effective treatments are lacking.Programmed cell death,which is a genetically determined fo rm of active and...
supported by National Institutes of Health grants R01 EY024986 and R01 EY028921,an unrestricted challenge grant from Research to Prevent Blindness;the New York Eye and Ear Infirmary Foundation;The Harold W.McGraw,Jr.Family Foundation for Vision Research(to BC)。
Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously,the central nervous system in adult mammals lacks the ability to com...