INTERLEUKIN

作品数:582被引量:1949H指数:19
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相关领域:医药卫生更多>>
相关作者:林静赵桂秋李桂仙李立维李倩更多>>
相关机构:四川大学浙江大学华中科技大学武汉大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state被引量:2
《Neural Regeneration Research》2024年第10期2229-2239,共11页Yubo Wang Ling Zhang Tianjie Lyu Lu Cui Shunying Zhao Xuechun Wang Meng Wang Yongjun Wang Zixiao Li 
supported by the National Natural Science Foundation of China,No.82171270 (to ZL);Public Service Platform for Artificial In telligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1 (to ZL);the Natural Science Foundation of Beijing,No.Z200016 (to ZL);Beijing Talents Project,No.2018000021223ZK03 (to ZL);Beijing Municipal Committee of Science and Technology,No.Z201 100005620010 (to ZL);CAMS Innovation Fund for Medical Sciences,No.2019-I2M-5-029 (to YongW)。
Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effec...
关键词:DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state INTERLEUKIN NEUROINFLAMMATION STROKE TET2 
Oligodendrocytes in central nervous system diseases:the effect of cytokine regulation被引量:2
《Neural Regeneration Research》2024年第10期2132-2143,共12页Chengfu Zhang Mengsheng Qiu Hui Fu 
supported by the Natural Science Foundation of Zhejiang Province,No.LQ23C090003 (to CZ);the Major Project on Brain Science and Analog Brain Research of Ministry of Science and Technology of China,No.2022ZD0204701 (to MQ);the National Natural Science Foundation of China,No.32170969 (to MQ)。
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular funct...
关键词:ASTROCYTE central nervous system disease CXC chemokine cytokine interferonγ INTERLEUKIN MICROGLIA OLIGODENDROCYTE oligodendrocyte precursor cell tumor necrosis factorα 
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats被引量:2
《Neural Regeneration Research》2023年第10期2208-2218,共11页Jia-Gui Huang Jiang-Xia Ren Yue Chen Ming-Fen Tian Li Zhou Jun Wen Xiao-Song Song You-Lin Wu Qing-Huan Yang Pei-Ran Jiang Jia-Ni Wang Qin Yang 
supported by the National Natural Science Foundation of China,Nos.82171456 (to QY),81971229 (to QY);the Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmX0263 (to QY);the Postgraduate Research and Innovation Project of Chongqing,Nos.CYB20151 (to QY),CYS19182 (to YC)。
In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly unders...
关键词:central nervous system extracellular matrix FIBRONECTIN fibrotic scar macrophage interleukin 4 ischemic cerebral injury neurological function Sonic hedgehog transforming growth factorβ1 
Interleukin 17A deficiency alleviates neuroinflammation and cognitive impairment in an experimental model of diabetic encephalopathy被引量:5
《Neural Regeneration Research》2022年第12期2771-2777,共7页Xiao-Xia Fang Fen-Fen Xu Zhan Liu Bei-Bei Cao Yi-Hua Qiu Yu-Ping Peng 
supported by the Natural Science Foundation of Jiangsu Province of China, No.BK20180948(to ZL);Nantong Applied Research Program of China, No.MS12019011(to XXF);Science and Technology Project of Nantong University of China, No.TDYXY2019007(to XXF)
Interleukin 17A(IL-17A)was previously shown to be a key pro-inflammatory factor in diabetes mellitus and associated complications.However,the role of IL-17A in diabetic encephalopathy remains poorly understood.In this...
关键词:Akita mice apoptosis cognitive impairment diabetic encephalopathy HIPPOCAMPUS interleukin 17A MICE MICROGLIA NEUROINFLAMMATION neuron targeted treatment 
Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury被引量:4
《Neural Regeneration Research》2018年第9期1650-1656,共7页Meng-Qiang Huang Xiao-Yu Cao Xu-Yi Chen Ying-Fu Liu Shuang-Long Zhu Zhong-Lei Sun Xian-Bin Kong Jing-Rui Huo Sai Zhang Yun-Qiang Xu 
financially supported by the National Natural Science Foundation of China,No.11672332,11102235,8167050417;the National Key Research and Development Plan of China,No.2016YFC1101500;the Key Science and Technology Support Foundation of Tianjin City of China,No.17YFZCSY00620;the Natural Science Foundation of Tianjin City of China,No.15JCYBJC28600,17JCZDJC35400
Nerve scarring after peripheral nerve injury can severely hamper nerve regeneration and functional recovery.Further,the anti-inflammatory cytokine,interleukin-10,can inhibit nerve scar formation.Saikosaponin a(SSa) ...
关键词:nerve regeneration saikosaponin a anti-inflammatory factor inflammation interleukin-l O nerve scar peripheral nerve injury sciatic nerve injury sciatic functional index nerve conduction velocity neuroelectrophysiological function neural regeneration 
Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis
《Neural Regeneration Research》2017年第10期1605-1606,共2页ángel Edo Juan Francisco Espinosa-Parrilla 
Gene therapy as strategy against autoimmune diseases: In the last century, human societies have witnessed remarkable improvements in wellness and life expectancy, thanks to the consolidation of mod- ern science and m...
Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approach in the MPTP model of Parkinson's disease被引量:2
《Neural Regeneration Research》2017年第9期1433-1434,共2页Bjorn Spittau 
supported by the Deutsche Forschungsgemeinschaft(DFG,SP 1555/2-1)
Parkinson's disease (PD) has been described as one of the most common neurodegenerative diseases affecting up to 2% of the worldwide population over 60 years of age. The hallmarks of PD are progressive loss of midb...
Mechanisms underlying the promotion of functional recovery by deferoxamine after spinal cord injury in rats被引量:10
《Neural Regeneration Research》2017年第6期959-968,共10页Jian Hao Bo Li Hui-quan Duan Chen-xi Zhao Yan Zhang Chao Sun Bin Pan Chang Liu Xiao-hong Kong Xue Yao Shi-qing Feng 
supported by the National Natural Science Foundation of China,No.81672171,81330042;the International Cooperation Program of National Natural Science Foundation of China,No.81620108018;a grant from the Ministry of Science and Technology of China,No.2014DFR31210;a grant from the Tianjin Science and Technology Committee of China,No.13RCGFSY19000,14ZCZDSY00044;the Youth Foundation of Tianjin Medical University General Hospital of China,No.ZYYFY2015008
Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in...
关键词:injured interleukin glial caspase saline underlying fibrillary minutes acidic neuronal 
The role of interleukin-6 in central nervous system demyelination被引量:1
《Neural Regeneration Research》2016年第12期1922-1923,共2页Filip Petkovic Bernardo Castellano 
supported by Spanish Ministry of Economy and Competitiveness(BFU2014-55459P);Part of this research was presented at X FENS Forum of Neuroscience,Copenhagen,Denmark,July 2016(poster presentation);“Astrocyte-targeted production of IL-6 reduces demyelination,axonal pathology and microglial activation in the cuprizone-mediated demyelination model”
Demyelination of the central nervous system(CNS)is a hallmark of multiple sclerosis(MS),chronic inflammatory and neurodegenerative disease.Chronic demyelination favors neurodegeneration of denuded axons,which is a...
关键词:interleukin disability neuronal irreversible despite microglia cytokine astrocyte maturation understood 
Neuroprotective effect of angiotensin Ⅱ type 2 receptor during cerebral ischemia/reperfusion被引量:5
《Neural Regeneration Research》2016年第7期1102-1107,共6页Chun-ye Ma Lin Yin 
Angiotensin Ⅱ type 2 receptor(AT2R) activation has been shown to protect against stroke,but its precise mechanism remains poorly understood.We investigated whether the protective effect of AT2 R against ischemia/re...
关键词:interleukin protective saline occlusion infarct understood suppression injected poorly physiological 
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