supported by the National Natural Science Foundation of China,No.82171270 (to ZL);Public Service Platform for Artificial In telligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1 (to ZL);the Natural Science Foundation of Beijing,No.Z200016 (to ZL);Beijing Talents Project,No.2018000021223ZK03 (to ZL);Beijing Municipal Committee of Science and Technology,No.Z201 100005620010 (to ZL);CAMS Innovation Fund for Medical Sciences,No.2019-I2M-5-029 (to YongW)。
Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effec...
supported by the Natural Science Foundation of Zhejiang Province,No.LQ23C090003 (to CZ);the Major Project on Brain Science and Analog Brain Research of Ministry of Science and Technology of China,No.2022ZD0204701 (to MQ);the National Natural Science Foundation of China,No.32170969 (to MQ)。
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular funct...
supported by the National Natural Science Foundation of China,Nos.82171456 (to QY),81971229 (to QY);the Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmX0263 (to QY);the Postgraduate Research and Innovation Project of Chongqing,Nos.CYB20151 (to QY),CYS19182 (to YC)。
In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly unders...
supported by the Natural Science Foundation of Jiangsu Province of China, No.BK20180948(to ZL);Nantong Applied Research Program of China, No.MS12019011(to XXF);Science and Technology Project of Nantong University of China, No.TDYXY2019007(to XXF)
Interleukin 17A(IL-17A)was previously shown to be a key pro-inflammatory factor in diabetes mellitus and associated complications.However,the role of IL-17A in diabetic encephalopathy remains poorly understood.In this...
financially supported by the National Natural Science Foundation of China,No.11672332,11102235,8167050417;the National Key Research and Development Plan of China,No.2016YFC1101500;the Key Science and Technology Support Foundation of Tianjin City of China,No.17YFZCSY00620;the Natural Science Foundation of Tianjin City of China,No.15JCYBJC28600,17JCZDJC35400
Nerve scarring after peripheral nerve injury can severely hamper nerve regeneration and functional recovery.Further,the anti-inflammatory cytokine,interleukin-10,can inhibit nerve scar formation.Saikosaponin a(SSa) ...
Gene therapy as strategy against autoimmune diseases: In the last century, human societies have witnessed remarkable improvements in wellness and life expectancy, thanks to the consolidation of mod- ern science and m...
supported by the Deutsche Forschungsgemeinschaft(DFG,SP 1555/2-1)
Parkinson's disease (PD) has been described as one of the most common neurodegenerative diseases affecting up to 2% of the worldwide population over 60 years of age. The hallmarks of PD are progressive loss of midb...
supported by the National Natural Science Foundation of China,No.81672171,81330042;the International Cooperation Program of National Natural Science Foundation of China,No.81620108018;a grant from the Ministry of Science and Technology of China,No.2014DFR31210;a grant from the Tianjin Science and Technology Committee of China,No.13RCGFSY19000,14ZCZDSY00044;the Youth Foundation of Tianjin Medical University General Hospital of China,No.ZYYFY2015008
Deferoxamine, a clinically safe drug used for treating iron overload, also repairs spinal cord injury although the mechanism for this action remains unknown. Here, we determined whether deferoxamine was therapeutic in...
supported by Spanish Ministry of Economy and Competitiveness(BFU2014-55459P);Part of this research was presented at X FENS Forum of Neuroscience,Copenhagen,Denmark,July 2016(poster presentation);“Astrocyte-targeted production of IL-6 reduces demyelination,axonal pathology and microglial activation in the cuprizone-mediated demyelination model”
Demyelination of the central nervous system(CNS)is a hallmark of multiple sclerosis(MS),chronic inflammatory and neurodegenerative disease.Chronic demyelination favors neurodegeneration of denuded axons,which is a...
Angiotensin Ⅱ type 2 receptor(AT2R) activation has been shown to protect against stroke,but its precise mechanism remains poorly understood.We investigated whether the protective effect of AT2 R against ischemia/re...