Objective: Exposure of the heart to repeated, brief episodes of coronary occlusion/reperfusion prevents lethal myocyte injury. Necrosis and apoptosis, two seemingly distinct mechanisms of cell death caused by ischemia...
supported by National Natural Science Foundation of China(Grant No.81770667);Scientific Research Project of Guangdong Provincial People’s Hospital-Summit plan(Grant No.KJ012019120,No.KJ012019433);Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases(Grant No.2019B121205005).
Acute kidney injury(AKI)with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease(CKD).At present,there is no curative drug to interrupt AKI-to-CKD progression.The nuclear factor...
Objective:To study the correlation between myocardial ischemia-reperfusion-induced monophasic action potential amplitude (MAPA) change and myocardial damage.Methods:New Zealand rabbits were selected as experimental an...
AIM: To investigate the effects of selenium in rat retinal ischemia reperfusion(IR) model and compare pretreatment and post-treatment use.METHODS: Selenium pre-treatment group(n =8) was treated with intraperitoneal(i....
Supported by AGAUR,No.2012FI_B00382,Generalitat de Catalunya,Barcelona,Spain,to Pantazi E;CSIC for the development program to Bejaoui M,No.I-COOP0005;The Fondo de Investigaciones Sanitarias,No.FIS PI12/00519
Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the case of organ transplantation.Several factors contribute to its complexity;the depletion of energy...
supported by the fund from the State Administration of Traditional Chinese Medicine (No.04-05JP61)
Objective:To study the effect of Chinese herbal medicine Kangxin Fumai Granule(康心复脉颗粒 Granule for heart diseases) serum on the primary cultured sinoatrial node(SAN) cell apoptosis induced by simulated ischemia-r...
Objective To investigate the effect of sevoflurane preconditioning and postconditioning on lung ischemia-reperfusion(IR) injury and apoptosis in rat.Methods Wistar rats were randomly assigned to four groups:sham group...
supported by a grant from the Science Foundation of Liaoning Province,China(No.20042064)
BACKGROUND:Gadolinium chloride(GdCl3)is a specific inhibitor of Kupffer cells(KCs),which are important promoters of various liver injuries.It is therefore of interest to explore the role of KCs in liver ischemia-reper...
In order to study the effects of ethyl pyruvate on cardiomyocyte apoptosis following ischemia/reperfusion (I/R) in vitro and the expression of Bcl-2 and Bax proteins, isolated rat hearts were perfused in a Langendor...
grants from the National Natural Science Foundation of China(No.30370533and30570671);Educational Department Science Research Foundation of Jiangsu Province(No. 05KJB310134)
Background We investigated the role in electrical stimulations of paraventricular nucleus (PVN) on gastric mucosal cells and the activity of mitogen-activated protein kinases (MAPKs) family members induced by gast...