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作品数：737被引量：2933H指数：21
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  • 期刊=Neural Regeneration Researchx
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The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury
《Neural Regeneration Research》2025年第11期3233-3244,共12页Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang 
supported by the TARCC,Welch Foundation Award(I-1724);the Decherd Foundation;the Pape Adams Foundation,NIH grants NS092616,NS127375,NS117065,NS111776。
The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following insults.Whether targeting this pathway is beneficial to b...
关键词：adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury 
Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway
《Neural Regeneration Research》2025年第11期3245-3258,共14页Jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao Han Zhongyue Lv Liang Wang Jing Liu 
supported by the National Nature Science Foundation of China,No.81471308(to JL);the Innovative Leading Talents of Liaoning Province,No.XLYC1902031(to JL);Science and Technology Projects in Liaoning Province,No.2022-BS-238(to CH);Young Top Talents of Liaoning Province,No.XLYC1907009(to LW);Dalian Science and Technology Innovation Fund,No.2018J11CY025(to JL)。
Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem ce...
关键词：behavior EXOSOME extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT) 
Overexpression of fibroblast growth factor 13 ameliorates amyloid-β-induced neuronal damage被引量：2
《Neural Regeneration Research》2023年第6期1347-1353,共7页Ruo-Meng Li Lan Xiao Ting Zhang Dan Ren Hong Zhu 
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer’s disease mouse models and patients,and that it plays a vital role in the learning and memory.However,the u...
关键词：AKT Alzheimer’s disease amyloid-β apoptosis cognitive dysfunction fibroblast growth factor 13 glycogen synthase kinase 3β neuronal damage oxidative stress phosphatidylinositol-3-kinase 
c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases被引量：4
《Neural Regeneration Research》2023年第2期237-243,共7页Daniela A.Gutiérrez América Chandía-Cristi María JoséYáñez Silvana Zanlungo Alejandra R.Alvarez 
supported by Comisión Nacional de Investigación Cientifica y Tecnologica-Chile Fondecyt 12011668(to ARA);Fondecyt 1190334(to SZ);Fondecyt 11200592(to MJY);Fondef ID21/10347(to ARA andSZ);Fondef D10E1077(to ARA and SZ);CARE-UCAFB 170005(to ARA);MSCA-RISE-2016-Lysomod-734825 European Union's Horizon 2020;Research and Innovation Program under the Marie Sklodowska-Curie grant agreement N°953489(to SZ);Millennium Science Initiative Program-ICN09_016/ICN 2021_045(to ARA)。
Our ability to learn and remember depends on the active formation,remodeling,and elimination of synapses.Thus,the development and growth of synapses as well as their weakening and elimination are essential for neurona...
关键词：actin cytoskeleton activity-dependent plasticity Alzheimer's disease C-ABL dendritic spines learning SYNAPSE synaptic plasticity transcription tyrosine kinase 
Phosphoinositide-3-kinase regulatory subunit 4 participates in the occurrence and development of amyotrophic lateral sclerosis by regulating autophagy被引量：1
《Neural Regeneration Research》2022年第7期1609-1616,共8页Yue Liu Cai-Hui Wei Cheng Li Wen-Zhi Chen Yu Zhu Ren-Shi Xu 
supported by the National Natural Science Foundation of China(Nos.30560042,81160161 and 81360198);Education Department of Jiangxi Province(No.GJJ170021);Jiangxi Provincial Department of Science and Technology(Nos.[2014]-47,20142BBG70062,20171BAB215022,20192BAB205043);Health Commission of Jiangxi Province(No.20181019)(all to RSX)。
The development of amyotrophic lateral sclerosis(ALS)may be related to the abnormal alterations of multiple proteins.Our previous study revealed that the expression of phosphoinositide-3-kinase regulatory subunit 4(PI...
关键词：amyotrophic lateral sclerosis AUTOPHAGY LC3 p62 PC12 cell phosphoinositide-3-kinase regulatory subunit 4 spinal cord Tg(SOD1*G93A)1Gur mice 
Dabrafenib,an inhibitor of RIP3 kinase-dependent necroptosis,reduces ischemic brain injury被引量：17
《Neural Regeneration Research》2018年第2期252-256,共5页Shelly A.Cruz Zhaohong Qin Alexandre E R.Stewart Hsiao-Huei Chen 
supported by grants from the Heart and Stroke Foundation of Canada(HHC,AFRS);the Canadian Institutes of Health Research(to HHC and AFRS);supported by a Mid-Career Investigator Award from the Heart and Stroke Foundation of Ontario
Ischemic brain injury triggers neuronal cell death by apoptosis via caspase activation and by necroptosis through activation of the receptor-interacting protein kinases （RIPK） associated with the tumor necrosis fact...
关键词：ischemic brain injury inflammation MACROPHAGE Dabrafenib tumor necrosis factor-alpha PHOTOTHROMBOSIS receptor-interacting protein kinases NECROPTOSIS microgIia stroke neural regeneration 
Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats被引量：21
《Neural Regeneration Research》2018年第1期112-118,共7页Shu-ju Wang Qi Wang Jun Ma Pei-hao Yu Zhong-ming Wang Bin Wang 
supported by the National Natural Science Foundation of China,No.81403456,81473788;a grant from the Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion,No.HBPCIC-2016-003
Defects in autophagy-mediated clearance of α-synuclein may be one of the key factors leading to progressive loss of dopaminergic neurons in the substantia nigra. Moxibustion therapy for Parkinson’s disease has been ...
关键词：nerve regeneration NEURODEGENERATION Parkinson＇s disease acupuncture MOXIBUSTION ROTENONE ALPHA-SYNUCLEIN AUTOPHAGY phosphorylated mammalian target of rapamycin kinase phosphorylated ribosomal protein S6 kinase light chain 3-II neural regeneration 
Possible divergence of serum-and glucocorticoid-inducible kinase function in ischemic brain injury
《Neural Regeneration Research》2016年第9期1396-1397,共2页Koichi Inoue 
As recent medical progress decreases the incidence of certain diseases, ischemic brain injury remains one of the major dis- eases that threaten human lives, especially in western countries. Ischemic brain injury occur...
关键词：SGK Possible divergence of serum-and glucocorticoid-inducible kinase function in ischemic brain injury 
Ischemic preconditioning protects against ischemic brain injury被引量：7
《Neural Regeneration Research》2016年第5期765-770,共6页Xiao-meng Ma Mei Liu Ying-ying Liu Li-li Ma Ying Jiang Xiao-hong Chen 
supported by grants from the National Natural Science Foundation of China,No.81071068;the Israel Science Foundation-the National Natural Science Foundation of China(Joint Program),No.813111290;the Natural Science Foundation of Guangdong Province in China,No.2014A030313172
In this study, we hypothesized that an increase in integrin αβand its co-activator vascular endothelial growth factor play important neuroprotective roles in ischemic injury. We performed ischemic preconditioning wi...
关键词：nerve regeneration brain injury integrin αvβ3 vascular endothelial growth factor vascular endothelial growth factor receptor vascular endothelial growth factor receptor-2 fetal liver kinase 1 ischemic preconditioning ischemic tolerance global cerebral ischemia cerebral ischemia cerebral infarction NSFC grant neural regeneration 
Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress被引量：14
《Neural Regeneration Research》2015年第8期1239-1244,共6页Jian-wen Yang Zhi-ping Hu 
Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize th...
关键词：nerve regeneration neuroprotection protein kinase-like endoplasmic reticulum kinase eukaryotic initiation factor 2α endoplasmic reticulum stress focal cerebral ischemia/reperfusion atorvastatin apoptosis 
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