Background The extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae has increasingly become a major contributor to nosocomial infections and can exhibit multiple antibiotic resistance.Previous stu...
Background Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (K.pneumoniae) is one of the most popular pathogens that cause refractory respiratory tract infection.The genetic environment,includ...
Background The extended spectrum 13-1actamase (ESBL)-producing Escherichia coil (E. coh) and Klebsiella pneumoniae (K. pneumoniae) are the major pathogens causing pneumonia and have a significant impact on the c...
Background Carbapenems are used to treat severe infections caused by multi-drug-resistant organisms, however, the emergence of carbapenem-resistant bacterial isolates is becoming an increasing therapeutic challenge. S...
This work was supported by grants from the National Basic Research Program of China, the Ministry of Science and Technology, China (No_ 2005CB0523101), the National Natural Science Foundation of China (No_ 30440061 and 30572229), the Science and Technology Commission of Shanghai Municipality (No_ 06XD14030), and the Shanghai Municipal Health Bureau (No_ LJ06052).Acknowledgements We thank George A JACOBY and David C HOOPER for providing reference strains E coli J53Az^R, E coli V517, and E coli R27. We are also grateful to George A JACOBY for critically reviewing the manuscript.
Aim: To identify the location and the relationship, and to analyze the genetic background of 2 plasmid-mediated quinolone resistance genes, qnrB4 and qnrS1, carried by a clinical strain of Klebsiella pneumoniae (Kpn...