L9981

作品数：35被引量：104H指数：5
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相关领域：医药卫生生物学更多>>
相关作者：周清华王艳萍朱文刘伦旭车国卫更多>>
相关机构：四川大学华西医院天津医科大学总医院四川大学天津市肺癌转移与肿瘤微环境重点实验室更多>>
相关期刊：《癌症》《云南医药》《生命科学研究》《中国肺癌杂志》更多>>
相关基金：国家自然科学基金国家教育部博士点基金中国博士后科学基金天津市科技支撑计划更多>>
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高低转移大细胞肺癌细胞株L9981和NL9980间甲基化差异基因的初步研究
《中国肺癌杂志》2010年第8期763-768,共6页吕慧 闫惠琴 王岷 李永文 万海粟 刘红雨 吴蘅 周清华 
国家自然科学基金重点项目(No.30430300);国家973重大项目(No.2010CB529405);国家863重大项目(No.2006AA02401)~~
背景与目的肺癌是人类肿瘤中最容易发生侵袭转移的恶性肿瘤之一。影响肺癌患者预后及生存的最主要因素是远处转移。本文旨在分析具有相似遗传背景和不同转移潜能的人大细胞肺癌细胞株间基因甲基化的差异,为深入研究肿瘤转移机制提供充...
关键词：甲基化基因芯片 DNA甲基化 转移 肺肿瘤 
The Molecular Mechanisms of Nm23-H1 Gene Transfection on Reversing Invasion and Metastasis Phenotype in Human High-metastataic Large Cell Lung Cancer Cell Line L9981
《中国肺癌杂志》2009年第6期I0009-I0011,共3页Qinghua ZHOU 
supported by the grants from the Key Project of National Natural Science Foundation of China (No.30430300 , to Qinghua ZHOU);Key Projects of Tianjin Sci-Tech Support Program (No. 07SY-SYSF05000 and No. 06YFSZSF05300, to Qinghua ZHOU)
Background: Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer could be reversed by transfection of nm23-H1 cDNA, but
关键词：癌细胞转移 肺癌 临床 治疗 
Alterations and Its Mechanisms of Wnt Signal Pathway in Human High-matastatatic Large Cell Lung Cancer Cell Line L9981 by Transfecting with Nm23-H1 Gene被引量：1
《中国肺癌杂志》2009年第6期477-479,共3页Junke FU Zhe WANG Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyu LIU Zhihao WU Ke XU Qinghua ZHOU 
supported by grants from National Natural Sciences Foundation of China (to Qinghua ZHOU, No.3007033 )
Backgroud and Objective Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the main cause of failure to cure and lose their life of the
关键词：肺癌 扩散 临床 化疗 
Changes of the Proteomic Profiles in Human High-metastatic Large Cell Lung Cancer Cell Line L9981 by Transfecting with nm23-H1 Gene
《中国肺癌杂志》2009年第6期479-480,共2页Youlin DENG Wen ZHU Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyy LIU Zhihao WU Ke XU Ojnghua ZHOU 
supported by the grants from the National Natural Science Foundation of China;Science Foundation of Sichuan University (No. 30070333 and No.200349)
Background and Objective Cancer metastasis is not only the malignant characteristics of lung cancer, but also the key cause of failure to cure and high mortality. It has been proved
关键词：肺癌 治疗 疗效 临床 
The Molecular Mechanisms of Nm23-H1 Gene Transfection on Reversing Invasion and Metastasis Phenotype in Human High-metastataic Large Cell Lung Cancer Cell Line L9981
《中国肺癌杂志》2009年第6期482-482,共1页Qjnghua ZHOU 
supported by the grants from the Key Project of National Natural Science Foundation of China (No.30430300 , to Qinghua ZHOU);Key Projects of Tian-jin Sci-Tech Support Program (No. 07SYSYSF05000 and No. 06YFSZSF05300, to Qinghua ZHOU)
Background and Objective Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer could
关键词：Nm23-H1细胞 肺癌 癌细胞 治疗 疗效 
Noninvasive Assessment of Using Bioluminescent Imaging(BLI) to Research Methylseleninic Acid' Effect on the Growth And Spontaneous Metastasis in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981
《中国肺癌杂志》2009年第6期505-506,共2页Yuanrong REN Yu FAN Li MA Jun CHEN Seng WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU 
supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300);National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922);INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)
Background and Objective The disease incidence and mortality of lung cancer has been increased dramatically for recent 50 years in many countries in the world. In2002, the new cases
关键词：肺癌 医学 化疗 疗效 
Influence of Nm23-H1 Gene Site Mutagenesis on Invasive And Metastatic Phenotype in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981
《中国肺癌杂志》2009年第6期515-517,共3页Daxing ZHU Bin HU Xiaomin Q IU Ting WANG Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU 
supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300);National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922);INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)
Background and Objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. To study and elucidate the molecular mechanism
关键词：NM23-H1 肺癌 治疗 疗效 
转录靶向性KDR启动子调控双自杀基因系统对人大细胞肺癌细胞L9981的杀伤作用被引量：1
《中国肺癌杂志》2009年第6期530-534,共5页车国卫 刘伦旭 周清华 王艳萍 朱文 付军科 孙江涛 王允 陈晓禾 
背景与目的研究KDR启动子转录调控双自杀基因系统(CDglyTK)对人大细胞肺癌细胞L9981的杀伤作用。方法应用分子生物学技术克隆KDR基因的启动子KDRp,构建KDR启动子调控的双自杀基因(CDglyTK)真核表达质粒pcDNA3-KDRp-CdglyTK。并将其导入L...
关键词：转录靶向性 KDR启动子 双自杀基因 基因治疗 肺癌 
The Effects of Intracellular Glutathione Content on the Sensitivity of Methylseleninic Acid to Human High-metastatic Large Cell Lung Cancer Cell Line L9981
《中国肺癌杂志》2009年第6期510-511,共2页Chengfei LIU Jun CHEN Liya SUN Yu ZHU Ting WANG Na-galakshmi NADIMINTY Allen C. GAO Qinghua ZHOU 
supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300);National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922);INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)
Background and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumors
关键词：肺癌 癌细胞 治疗 疗效 
Alterations in the Cytoskeleton and Biological Behavior in Human Lung Cancer Cell Line L9981 by Nm23-H1 gene Transfection
《中国肺癌杂志》2009年第6期475-476,共2页Zhe WANG Junke FU Zhihao WU Hongyu LIU Jun CHEN Liya SUN Q inghua ZHOU 
supported by the grants from the Key Project of National Natural Science Foundation of China (No .30430300 , to Qinghua ZHOU);Key Projects of Tian-jin Sci-Tech Support Program (No . 07SY SY SF05000 and No 06YFSZSF05300, to Qinghua ZHOU)
Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known
关键词：肺癌 治疗 诊断 疗效 
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