LETHAL

作品数：177被引量：326H指数：10
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Comparison of the pathogenicity and neutrophil and monocyte response between SARS-CoV-2 prototype and Omicron BA.1 in a lethal mouse model
《Animal Models and Experimental Medicine》2025年第4期707-717,共11页Na Rong Jing Wu Binbin Zhao Wanjun Peng Hekai Yang Gengxin Zhang Dangting Ruan Xiaohui Wei Jiangning Liu 
supported by Beijing Natural Science Foundation(Grant No.Z210014);National Natural Science Foundation of China(Grant No.32070543);National Key Research and Development Project of China(Grant No.2022YFC2303404);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant No.2022-12M-CoV19-002)
Background:SARS-CoV-2,first identified in late 2019,has given rise to numerous variants of concern(VOCs),posing a significant threat to human health.The emer-gence of Omicron BA.1.1 towards the end of 2021 led to a pa...
关键词：animal model SARS-CoV-2 Omicron BA.1 MONOCYTE NEUTROPHIL 
Hyperosmolality tolerance of freshwater largemouth bass Micropterus salmoides to brackish in early ontogenetic stages of eggs,embryos,and yolk-sac larvae
《Journal of Oceanology and Limnology》2025年第1期286-298,共13页Du LUO Dingtian YANG 
the Natural Science Foundation of Guangdong Province(No.2016A030313145);the National Key R&D Program of China(No.2018YFD0900901);the Central Public-interest Scientific Institution Basal Research Fund,Chinese Academy of Fishery Sciences(No.2024SJRC9)。
Salinity is recognized as a pivotal factor limiting the migration of freshwater fish to brackish environments.The largemouth bass(LMB,Micropterus salmoides),a globally translocated freshwater fish,exhibits estuarine d...
关键词：osmotic homeostasis acute toxicity median lethal time hatching rate dose-response model 
Case Report:Laubry-Pezzi Syndrome:Confronting the Lethal Nexus of Life-Threatening Complications in Resource Constrained Settings
《Congenital Heart Disease》2024年第6期635-645,共11页Hayatu Uma Abdulaziz Aminu Raghu Cherukupalli Femi Akindotun Akintomide Abdul Habu Aisha Aminu Lawal Adamu Mohammad 
Laubry-Pezzi syndrome(L-PS)is a rare congenital heart disease characterized by a ventricular septal defect(VSD)and aortic valve prolapse.These cardiac lesions predispose individuals to infective endocarditis(IE),a lif...
关键词：Laubry-Pezzi syndrome ventricular septal defect aortic valve prolapse infective endocarditis SEPSIS 
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer
《Acta Pharmaceutica Sinica B》2024年第12期5219-5234,共16页Jiayu Zhang Yingxi Zhao Ruijuan Liang Xue Zhou Zhonghua Wang Cheng Yang Lingyue Gao Yonghao Zheng Hui Shao Yang Su Wei Cui Lina Jia Jingyu Yang Chunfu Wu Lihui Wang 
supported by grants from the National Natural Science Foundation of China(82272725 to Chunfu Wu,82073320 to Lihui Wang);“Xingliao Talents”Program of Liaoning Province(No.XLYC1902008 to Lihui Wang,China);Natural Science Foundation of Shenyang(22-315-6-11 to Lihui Wang,China).
DNMT3A encodes a DNA methyltransferase involved in development,cell differentiation,and gene transcription,which is mutated and aberrant-expressed in cancers.Here,we revealed that loss of DNMT3A promotes malignant phe...
关键词：DNMT3A NSCLC Synthetic lethal HDAC6 HIF-1 
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose-and tissue factor-dependent manner
《Acta Pharmacologica Sinica》2024年第11期2300-2312,共13页Bian-lei Yang Yao-ying Long Qian Lei Fei Gao Wen-xiang Ren Yu-lin Cao Di Wu Liu-yue Xu Jiao Qu He Li Ya-li Yu An-yuan Zhang Shan Wang Hong-xiang Wang Zhi-chao Chen Qiu-bai Li 
supported by grants from the National Key Research and Development Program of China(2021YFA1101500);the National Natural Science Foundation of China(81974221,81974009,and 92049119);the Hubei Innovation Group Foundation(2022CFA019);the General Program of Health Commission of Hubei Province(WJ2023M126).
Mesenchymal stem cell-derived extracellular vesicles(MSC-EVs)have obvious advantages over MSC therapy.But the strong procoagulant properties of MSC-EVs pose a potential risk of thromboembolism,an issue that remains in...
关键词：mesenchymal stem cells extracellular vesicles tissue factor COAGULATION pulmonary thromboembolism HEPARIN 
Author Correction:Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis
《Cellular & Molecular Immunology》2024年第10期1175-1176,共2页Quan-Zhen Lv De-Dong Li Hua Han Yi-Heng Yang Jie-Lin Duan Hui-Hui Ma Yao Yu Jiang-Ye Chen Yuan-Ying Jiang Xin-Ming Jia 
In this article,which was published online on 5 Nov 2020,an unintended error occurred during the image processing of Fig.7J.In detail,the image for the control group in Figure 7J(left panel)was inadvertently captured ...
关键词：Figure corrected CORRECTION 
Dysbiosis and colonic adenoma: The lethal link?
《World Journal of Clinical Oncology》2024年第10期1376-1378,共3页Krishna Kumar Govindarajan 
Gut dysbiosis,a phenomenon in which the existing commensal microbiome cha-nges to an adverse microenvironment in the colon,is thought to lead to altered cellular signals.How this is involved in producing mucosal outgr...
关键词：DYSBIOSIS ADENOMA POLYP GUT MICROBIOTA 
Costa Rica's Cave of Death is lethal to any creature
《疯狂英语（新读写）》2024年第9期52-53,77,78,共4页高坚 
Activity 1.Think about the following questions and write down your answers before reading the text.1.What do you think might be the most dangerous thing in exploring such mysterious caves?2.If you could discover a new...
关键词：features SUCH DANGEROUS 
Epigenetic silencing of BEND4,a novel DNA damage repair gene,is a synthetic lethal marker for ATM inhibitor in pancreatic cancer被引量：1
《Frontiers of Medicine》2024年第4期721-734,共14页Yuanxin Yao Honghui Lv Meiying Zhang Yuan Li James G.Herman Malcolm V.Brock Aiai Gao Qian Wang Francois Fuks Lirong Zhang Mingzhou Guo 
supported by grants from the National Key Research and Development Program of China(Nos.2018YFA0208902 and 2020YFC2002705);the National Natural Science Foundation of China(Nos.82272632 and 81672138);Beijing Science Foundation of China(No.7171008)。
Synthetic lethality is a novel model for cancer therapy.To understand the function and mechanism of BEN domain-containing protein 4(BEND4)in pancreatic cancer,eight cell lines and a total of 492 cases of pancreatic ne...
关键词：BEND4 DNA methylation synthetic lethality NHEJ pathway 
Injectable and rapidly expandable thrombin-decorated cryogels achieve rapid hemostasis and high survival rates in a swine model of lethal junctional hemorrhage
《Bioactive Materials》2024年第8期154-168,共15页Syed Muntazir Andrabi S.M.Shatil Shahriar Al-Murtadha Al-Gahmi Benjamin L.Wilczewski Mark A.Carlson Jingwei Xie 
supported by startup funds from the University of Nebraska Medical Center(UNMC)and Congressionally Directed Medical Research Program(CDMRP)/Peer Reviewed Medical Research Program(PRMRP)FY19 W81XWH2010207 to J.X.;M.A.C.We thank the Proteomics&Metabolomics Facility(RRID:SCR_021314),Nebraska Center for Biotechnology at the University of Nebraska-Lincoln for the mass spectrometry analysis.The facility and instrumentation are supported by the Nebraska Research Initiative.
Effective therapies are urgently needed to stabilize patients with marginally compressible junctional hemorrhage long enough to get them to the hospital alive.Herein,we report injectable and rapidly expandable cryogel...
关键词：Polyacrylamide cryogels Blood clotting Shape memory and injectable Lethal junctional hemorrhage 
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