MATRIX_METALLOPROTEINASES

作品数：148被引量：792H指数：15
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相关机构：吉林大学北京市耳鼻咽喉科研究所中国科学院首都医科大学更多>>
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Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis
《World Journal of Methodology》2025年第2期108-116,共9页Bhari Sharanesha Manjunatha Keshav T Handge Vandana Sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel 
BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors...
关键词：Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging IMMUNOHISTOCHEMISTRY INVASION Lymph node metastasis TNM stage 
Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling
《World Journal of Experimental Medicine》2025年第2期1-11,共11页Marc Irqsusi Fiona R Rodepeter Madeline Günther Andreas Kirschbaum Sebastian Vogt 
Aneurysms and dissections represent some of the most serious cardiovascular diseases.The prevailing theory posits that mechanical overloading of the vessel wall is the underlying cause.Inspired by Barkhordarian et al,...
关键词：Matrix metalloproteinases Tissue inhibitor of metalloproteinases Acute aortic dissection Aortic aneurysm Extracellular matrix remodeling PATHOGENESIS 
Prognostic prediction model for Chinese uveal melanoma patients based on matrix metalloproteinase-2 and-28 expression levels in the tumor
《International Journal of Ophthalmology(English edition)》2025年第5期765-778,共14页Yu-Ning Chen Jing-Ying Xiu Han-Qing Zhao Jing-Ting Luo Qiong Yang Yang Li Wen-Bin Wei 
Supported by the National Natural Science Foundation of China(No.82220108017,No.82141128,No.82101180);Beijing Natural Science Foundation(No.Z220012);The Capital Health Research and Development of Special(No.2020-1-2052);Science&Technology Project of Beijing Municipal Science&Technology Commission(No.Z201100005520045);Sanming Project of Medicine in Shenzhen(No.SZSM202311018);Beijing Science&Technology Development of TCM(No.BJZYYB-2023-17).
AIM:To explore the relationship between matrix metalloproteinases(MMPs)expression levels in the tumor and the prognosis of uveal melanoma(UM)and to construct prognostic prediction models.METHODS:Transcriptome sequenci...
关键词：uveal melanoma matrix metalloproteinases prediction model PROGNOSIS tumor microenvironment 
Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury:Insights from RNA sequencing for diagnosis and therapy
《World Journal of Gastrointestinal Surgery》2025年第2期25-36,共12页Dao-Jian Xu Guo-Tao Wang Qiang Zhong 
Supported by Health Science and Technology Programme of Zhejiang Province,No.2022KY1391.
Intestinal ischemia-reperfusion injury(IIRI)is a complex and severe pathophysiological process characterized by oxidative stress,inflammation,and apoptosis.In recent years,the critical roles of extracellular matrix(EC...
关键词：Diagnostic biomarkers Extracellular matrix Gene expression Intestinal ischemia-reperfusion injury Matrix metalloproteinases MICRORNA Treatment strategies 
Integrating network pharmacology and in vivo pharmacological investigation for deciphering the mechanism of Simiao Yong’an decoction in alleviating rheumatoid arthritis
《Guideline and Standard in Chinese Medicine》2024年第4期215-227,共13页Shanshan Jie Yan Gao Huijuan Sun Hongyan Zhao Yukun Zhao Chen Chen Hui Zeng Yaluan Ma 
supported by a research project of the China Academy of Chinese Medical Sciences(Y.M.,No.YZ-202016,China).
Objective:To investigate the mechanism of Simiao Yong’an Decoction in alleviating the damage of rheumatoid arthritis(RA),and accordingly provide pharmacological evidence and further experimental support for the appli...
关键词：rheumatoid arthritis Simiao Yong’an Decoction network pharmacology myeloid cells matrix metalloproteinases 
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway
《Acta Pharmacologica Sinica》2024年第9期1848-1860,共13页Feng-ting Lu Cheng-cui Huang Wen-yi Lai Gui-yong Yang Zhu-jun Liang Zi-yi Zhang Tanvi Chokshi Kai-min Guo Yu-bo Tang Yuan Chen Zhong-han Yang Si-jia Liang Rui-ping Pang Jia-guo Zhou Yong-yuan Guan Xiao-fei Lv Ming-ming Ma 
National Natural Science Foundation of China(No.82373866 to MM Ma,No.81773721 to YY Guan,No.81903598 to XF Lv,No.82073839 to SJ Liang,No.82360312 to KM Guo);Natural Science Foundation of Guangdong Province(2021A1515012427 and 2022A1515012471 to MM Ma,2021A1515010378 to XF Lv);Science and Technology Program of Guangzhou(202201020610 to KM Guo);Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22ykqb09 to SJ Liang).
Hypertensive cerebrovascular remodeling involves the enlargement of vascular smooth muscle cells(VSMCs),which activates volume-regulated Cl−channels(VRCCs).The leucine-rich repeat-containing family 8 A(LRRC8A)has been...
关键词：extracellular matrix FOXO3A LRRC8A matrix metalloproteinases vascular remodeling WNK1 
Transforming growth factor-β receptors:versatile mechanisms of ligand activation被引量：1
《Acta Pharmacologica Sinica》2024年第7期1337-1348,共12页Zheng-Jie Chia Ying-nan Cao Peter J.Little Danielle Kamato 
supported by a Future Leader Fellowship (106605)from the National Heart Foundation of Australia.
Transforming growth factor-β(TGF-β)signaling is initiated by activation of transmembrane TGF-βreceptors(TGFBR),which deploys Smad2/3 transcription factors to control cellular responses.Failure or dysregulation in t...
关键词：TGFBR receptor Smads THROMBOSPONDINS matrix metalloproteinases INTEGRINS TRANSACTIVATION 
Multimodal comparison of plasma proteins associated with blood-brain barrier impairment in Alzheimer’s disease
《Aging Communications》2024年第1期1-9,共9页Elisa Giunti Roberto Collu Joel Reisman Jong Soo Lee Noureddine Melikechi Weiming Xia 
University of Massachusetts Lowell-Bedford VA Healthcare System Pilot Award(NM,WX,EG),I01 BX004730 and I01 BX003527 Merit Awards from the Biomedical Laboratory Research and Development of the Veterans Affairs Office of Research and Development(WX);RF1AG063913 from the NIH(WX).
Background:Vascular impairment is one of the major contributors to dementia.We aimed to identify blood biomarkers suggestive of potential impairment of the blood-brain barrier(BBB)in subjects with Alzheimer’s disease...
关键词：Alzheimer’s disease blood-brain barrier peripheral biomarkers matrix metalloproteinases cerebral amyloid angiopathy 
Placenta-derived mesenchymal stem cells attenuate secondary brain injury after controlled cortical impact in rats by inhibiting matrix metalloproteinases
《BIOCELL》2024年第1期149-162,共14页PING YANG YUANXIANG LAN ZHONG ZENG YAN WANG HECHUN XIA 
financially supported by the Key Research Projects of Ningxia Hui Autonomous Region of China under Grant No.2018BCG01002(to HCX).
Background:As a form of biological therapy,placenta-derived mesenchymal stem cells(PDMSCs)exhibit considerable promise in addressing the complex pathological processes of traumaticbrain injury(TBI)due to their multi-t...
关键词：Traumatic brain injury Mesenchymal stem cells Oxidative stress Matrix metalloproteinases 
Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy被引量：3
《Cell Regeneration》2023年第1期91-106,共16页Peng Zhao Tian Sun Cheng Lyu Kaini Liang Yanan Du 
financially supported by the National Natural Science Foundation of China(82125018).
Investigation into the role of cells with respect to extracellular matrix(ECM)remodeling is still in its infancy.Particularly,ECM degradation is an indispensable process during the recovery from fibrosis.Cells with EC...
关键词：FIBROSIS Extracellular matrix DEGRADATION Matrix metalloproteinases 
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