TRANSACTIVATION

作品数：42被引量：152H指数：8
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Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling
《Acta Pharmacologica Sinica》2025年第4期795-804,共10页Zheng-Jie Chia Hirushi Kumarapperuma Ruizhi Zhang Peter J.Little Danielle Kamato 
supported by a Future Leader Fellowship(106605)from the National Heart Foundation of Australia;HK and ZJC are supported by the Research Training Scholarship from the University of Queensland.
The Smad transcription factors are well known for their role at the core of transforming growth factor-β(TGF-β)signalling.However,recent evidence shows that the Smad transcription factors play a vital role downstrea...
关键词：transforming growth factor-beta receptor SMAD transactivation dependent GPCR signalling Akt phospho-Smad 
Hp FBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya
《Journal of Integrative Agriculture》2025年第2期575-593,共19页Xiaowei Cai Ling Xiao Xiangmei Nie Qiandong Hou Sulin Wen Kun Yang Xiaopeng Wen 
supported by the National Natural Science Foundation of China(32160681 and 32060663);the National Guidance Foundation for Local Science and Technology Development of China(2023-009);the Guizhou Provincial Basic Research Program(Natural Science)(ZK[2022]YB132);the Foundation of Postgraduate of Guizhou Province,China(YJSKYJJ[2021]057)。
Hylocereus polyrhizus,also known as pitaya or dragon fruit,is a climbing cactus grown worldwide because of its excellent performance under drought stress and appealing red-purple fruits.In practice,accelerating flower...
关键词：PITAYA FLOWERING BHLH DIMERIZATION TRANSACTIVATION flower formation 
Transforming growth factor-β receptors:versatile mechanisms of ligand activation被引量：1
《Acta Pharmacologica Sinica》2024年第7期1337-1348,共12页Zheng-Jie Chia Ying-nan Cao Peter J.Little Danielle Kamato 
supported by a Future Leader Fellowship (106605)from the National Heart Foundation of Australia.
Transforming growth factor-β(TGF-β)signaling is initiated by activation of transmembrane TGF-βreceptors(TGFBR),which deploys Smad2/3 transcription factors to control cellular responses.Failure or dysregulation in t...
关键词：TGFBR receptor Smads THROMBOSPONDINS matrix metalloproteinases INTEGRINS TRANSACTIVATION 
Fusion of a rice endogenous N-methylpurine DNA glycosylase to a plant adenine base transition editor ABE8e enables A-toK base editing in rice plants被引量：1
《aBIOTECH》2024年第2期127-139,共13页Yucai Li Shaoya Li Chenfei Li Chen Zhang Lei Yan Jingying Li Yubing He Yan Guo Lanqin Xia 
funded by the National Natural Science Foundation of China(Grant No.32188102 to L.X),Hainan Yazhou Bay Seed Lab(Grant No.B23CJ0208 to L.X);the Central Public-interest Scientific Institution Basal Research Fund(Grant No.ZDXM2308 to L.X);National Engineering Research Centre of Crop Molecular Breeding.
Engineering of a new type of plant base editor for simultaneous adenine transition and transversion within the editing window will greatly expand the scope and potential of base editing in directed evolution and crop ...
关键词：Rice(Oryza sativa L) Rice N-methylpurine DNA glycosylase(OsMPG) A-to-K base editor(AKBE) Transactivation module VP64 
Engineering a plant A-to-K base editor with improved performance by fusion with a transactivation module被引量：4
《Plant Communications》2023年第6期225-229,共5页Yucai Li Shaoya Li Chenfei Li Chen Zhang Lei Yan Jingying Li Yubing He Yan Guo Yong Lin Yangjun Zhang Lanqin Xia 
funded by the National Natural Science Foundation of China(grant no.32188102 to L.X.);the Hainan Yazhou Bay Seed Lab(grant no.B23CJ0208 to L.X.);the Central Publicinterest Scientific Institution-Based Research Fund(grant no.ZDXM2308 to L.X.);the National Engineering Research Centre of Crop Molecular Breeding.
Dear Editor,Base editors(BEs)are promising tools that enable single-nucleotide substitutions in specific target genes,generating loss-offunction or gain-of-function mutations,which can greatly accelerate plant functio...
关键词：CBE EDITOR BASE 
GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib被引量：3
《Acta Pharmacologica Sinica》2022年第6期1534-1543,共10页Le-ying Chen Qing You Da-zhao Lv Shuai-hu Li Shi-yi Zhang 
This work was,in part,supported by the Youth Thousand Talents Program of China,start-up grants from the Shanghai Jiao Tong University(WF220408211);This work was also supported by the grants from the State Key Laboratory of Onco-genes and Related Genes(90-17-02);from the Interdisciplinary Program of Shanghai Jiao Tong University(YG2017MS18).
Many G-protein-coupled receptor(GPCR)agonists have been studied for transactivating epidermal growth factor receptor(EGFR)signaling through extracellular or intracellular pathways.Accumulated evidence has confirmed th...
关键词：GPCR agonist EGFR transactivation EGFR inhibitor RASH 
Rice GLUTATHIONE PEROXIDASE1-mediated oxidation of bZIP68 positively regulates ABA-independent osmotic stress signaling被引量：5
《Molecular Plant》2022年第4期651-670,共20页Heng Zhou Feng Zhang Fengchao Zhai Ye Su Ying Zhou Zhenglin Ge Priyadarshini Tilak Jürgen Eirich Iris Finkemeier Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie 
supported by grants from the National Natural Science Foundation of Jiangsu Province(BK20200561);the National Natural Science Foundation of China(32101671 and 31670255);the National Natural Science Foundation of Jiangsu Province(BK20200282 and BK20161447);the National Science Fund for Outstanding Young Scholars(21922702);the China Postdoctoral Science Foundation(2019M661860);the Fundamental Research Funds for the Central Universities(KYZ201859).
Osmotic stress caused by drought and high salinity is a significant environmental threat that limits plant growth and agricultural yield. Redox regulation plays an important role in plant stress responses, but the mec...
关键词：GPX1 SOH oxidative stress ACETYLATION ZIP68 TRANSACTIVATION 
Hydrogen sulfide-linked persulfidation of ABI4 controls ABA responses through the transactivation of MAPKKK18 in Arabidopsis被引量：10
《Molecular Plant》2021年第6期921-936,共16页Mingjian Zhou Jing Zhang Jie Shen Heng Zhou Didi Zhao Cecilia Gotor Luis CRomero Ling Fu Zongmin Li Jing Yang Wenbiao Shen Xingxing Yuan Yanjie Xie 
supported by grants from the National Natural Science Foundation of China(31670255);the National Natural Science Foundation of China of Jiangsu Province(BK20200561,BK20200282,BK20161447);the National Science Fund for Outstanding Young Scholars(21922702);the China Postdoctoral Science Foundation(2019M661860);the Fundamental Research Funds for the Central Universities(KYZ201859);the European Regional Development Fund through the Agenda Estatal de Investigacion(grant no.PID2019-109785GB-IOO).
Hydrogen sulfide(H2S)is a signaling molecule that regulates plant hormone and stress responses.The phytohormone abscisic acid(ABA)plays an important role in plant adaptation to unfavorable environmental conditions and...
关键词：hydrogen sulfide persulfidation DES1 ABI4 MAPKXK18 transactivation ABA response 
Role of vitamin D receptor in the regulation of CYP3A gene expression被引量：13
《Acta Pharmaceutica Sinica B》2019年第6期1087-1098,共12页Xuan Qin Xin Wang 
supported in part by grants from the National Natural Science Foundation of China(No.81773808);the Science and Technology Commission of Shanghai Municipality(Nos.17140901000,17140901001 and 18430760400,China).
Vitamin D3(VD3)is a multifunctional nutrient which can be either synthesized or absorbed from the diet.It plays a pivotal role in systemic calcium and phosphate homeostasis,as well as in various physiological and path...
关键词：VITAMIN D3 VDR CYP3A TRANSACTIVATION PHARMACOKINETIC Drug metabolism 
Specific activation of mGlu2 induced IGF-1R transactivation in vitro through FAK phosphorylation
《Acta Pharmacologica Sinica》2019年第4期460-467,共8页Yong-jian Hu Qian Sun Wen-hua Zhang Yu-jia Huo Chan-juan Xu Jian-feng Liu 
National Natural Science Foundation of China (NSFC grant nos. 31420103909, 31711530146, 31511130131);the Program of Introducing Talents of Discipline to the Universities of the Ministry of Education (grant no. B08029), Natural Science Foundation of.
Metabotropic glutamate receptor 2 (mGlu2) belongs to the group-ll metabotropic glutamate (mGlu) receptors and is a neurotransmitter G protein-coupled receptor. The group-ll mGlu receptors are promising antipsychotic t...
关键词：METABOTROPIC glutamate RECEPTOR 2 INSULIN-LIKE growth factor 1 RECEPTOR TRANSACTIVATION FAK ERK1/2 LY379268 LY487379 mouse cortical neurons 
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