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MITOCHONDRIAL_DNA: 作品数：250被引量：565H指数：10; 导出分析报告; 相关作者：张亚平程起群吴桂生李家乐沈玉帮更多>>; 相关机构：中国科学院上海海洋大学中国水产科学研究院东海水产研究所贵阳医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

Complexities and pitfalls in analyzing and interpreting mitochondrial DNA content in human cancer: 《Journal of Genetics and Genomics》2020年第7期349-359,共11页Hieu Nguyen Thomas LaFramboise; Mutations in the human mitochondrial genome have been observed in all types of human cancer,indicating that mutations might contribute to tumorigenesis,metastasis,recurrence,or drug response.This possibility is appeal...; 关键词：Mitochondrial DNA Cancer Genetic variation

Using MutPred derived mtDNA load scores to evaluate mtDNA variation in hypertension and diabetes in a two-population cohort：The SABPA study被引量：1: 《Journal of Genetics and Genomics》2017年第3期139-149,共11页Marianne Venter Leone Malan Etresia van Dyk Joanna L.Elson Francois H.van der Westhuizen; the Faculty of Natural Sciences of the NorthWest University for contributing to funding and Thermo Fisher South Africa for providing additional technical resources to this study;partially funded by the South African National Research Foundation;Medical Research Council;ROCHE Diagnostics;North-West University,South Africa;as well as the Metabolic Syndrome Institute,France;funding support from the Royal Society and the National Research Foundation of South Africa, for the academic meeting at which the project was mapped out; Mitochondrial DNA（mt DNA） variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also consid...; 关键词：Mitochondrial DNA MutPred Mutational load HYPERTENSION Diabetes AFRICAN SABPA

A cryptic mitochondrial DNA link between North European and West African dogs: 《Journal of Genetics and Genomics》2017年第3期163-170,共8页Adeniyi C.Adeola Sheila C.Ommeh Jiao-Jiao Song S.Charles Olaogun Oscar J.Sanke Ting-Ting Yin Guo-Dong Wang Shi-Fang Wu Zhong-Yin Zhou Jacqueline K.Lichoti Bernard R.Agwanda Philip M.Dawuda Robert W.Murphy Min-Sheng Peng Ya-Ping Zhang; supported by Sino-Africa Joint Research Center, Chinese Academy of Sciences (Nos. SAJC201611 and SAJC201306);the National Basic Research program (Nos. 2013CB835200 and 2013CB835202);The Youth Innovation Promotion Association, Chinese Academy of Sciences, provided support to M.S.P. and G.D.W.;supported by the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (the Large Research Infrastructure Funding);supported, in part, by a Visiting Professorship for Senior International Scientists from the Chinese Academy of Sciences;manuscript preparation by a Natural Sciences and Engineering Research Council of Canada Discovery Grant A3148 to R.W.M; Domestic dogs have an ancient origin and a long history in Africa. Nevertheless, the timing and sources of their introduction into Africa remain enigmatic. Herein, we analyse variation in mitochondrial DNA（mt DNA） D...; 关键词：Dog Mitochondrial DNA Africa Haplogroup D Late-glacial dispersal HYBRIDIZATION

Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies被引量：1: 《Journal of Genetics and Genomics》2015年第4期169-172,共4页Antonio Salas Joanna L.Elson; the "Ministerio de Ciencia e Innovacio'n"(No.SAF2011-26983);the Plan Galego IDT(No.EM 2012/045);the grant from the Sistema Universitario Gallego-Modalidad REDES(No.2012-PG226,to A.Salas) from the Xunta de Galicia; During the last decade, hundreds of studies have been pub- lished examining whether significant associations exist be- tween mitochondrial DNA （mtDNA） variants and/or haplogroups （clades） and particular diseases ...; 关键词：DNA Mitochondrial DNA as a Risk Factor for False Positives in Case-Control Association Studies

Sperm Mitochondria in Reproduction:Good or Bad and Where Do They Go?被引量：8: 《Journal of Genetics and Genomics》2013年第11期549-556,共8页Shi-Ming Luo Heide Schatten Qing-Yuan Sun; supported by the Major Basic Research Program(Nos.2012CB944404 and 2011CB944501);the National Natural Science Foundation of China(No.30930065)to Q.Y.S; The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA （mtDNA） also contributes to oxidative phosphorylation to impact production of ATP ...; 关键词：Mitochondrial DNA Maternal inheritance Paternal inheritance Autophagy Oxidative phosphorylation UBIQUITINATION

Association between mitochondrial DNA haplotype compatibility and increased efficiency of bovine intersubspecies cloning被引量：3: 《Journal of Genetics and Genomics》2011年第1期21-28,共8页Hao Yan Zhonghai Yan Qingwen Ma Fei Jiao Shuzhen Huang Fanyi Zeng Yitao Zeng; This work was supported by the grants from the National High-Tech R&D Program of China(No.2007AA100502);the National Science and Technology Major Project of China (No.2008ZX08007-004);the National Natural Science Foundation of China(No.30770242); Reconstructed embryos derived from intersubspecies somatic cell nuclear transfer （SCNT） have poorer developmental potential than those from intrasubspecies SCNT. Based on our previous study that Holstein dairy bovi...; 关键词：Somatic cell nuclear transfer （SCNT） MITOCHONDRIA mtDNA haplotype Epigenetic modification BOVINE Intersubspecis Intrasubspecis Developmental competence

Mitochondrial tRNA^(Glu) A14693G variant may modulate the phenotypic manifestation of deafness-associated 12S rRNA A1555G mutation in a Han Chinese family被引量：7: 《Journal of Genetics and Genomics》2009年第4期241-250,共10页Yu Ding Yongyan Li Junyan You Li Yang Bobei Chen Jianxin Lu Min-Xin Guan; supported by the Public Health Service grants (No. RO1DC05230 and RO1DC07696) from the National Institute on Deafness and Other Communication Disorders;grants from the National Basic Research Priorities Program of China (No. 2004CCA02200);the Ministry of Science and Technology of Zhejiang Province (No. 2007G50G2090026); Mutations in mitochondrial 12S rRNA gene are one of the most important causes of aminoglycoside-induced and nonsyndromic hearing loss. Here we report the characterization of one Han Chinese pedigree with aminoglycosid...; 关键词：hearing loss mitochondrial DNA mutation MODIFIER 12S rRNA tRNA Chinese family

Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation被引量：4: 《Journal of Genetics and Genomics》2008年第11期649-655,共7页Wanshi Cai Qun Fu Xiangtian Zhou Jia Qu Yi Tong Min-Xin Guan; Zhejiang Provincial Natural Science Foundation（ZB0202）；Chinese Young Scholar Award（No.30628013）；the National Science Foundation of China to M.X.G and the Key Research and Development Program from Zhejiang Province（No.2004C14005）to J.Q.; We report here the characterization of a five-generation Han Chinese family with Leber＇s hereditary optic neuropathy （LHON）. Strik- ingly, this Chinese family displayed high penetrance and expressivity of visual lo...; 关键词：Leber＇s hereditary optic neuropathy mitochondrial DNA MUTATION HAPLOTYPE vision loss MODIFIER Chinese

Comparative analysis of mitochondrial fragments transferred to the nucleus in vertebrate: 《Journal of Genetics and Genomics》2008年第8期485-490,共6页Hongying Qu Fei Ma Qingwei Li; the National Natural Science Foundation of China (No. 30470936); Mitochondrial DNA sequences transferred to the nucleus give rise to the so-called nuclear mitochondrial DNA （numt）. In the GenBank database, 244 numts have been found in six orders of birds （Anseriformes, Columbifo...; 关键词：mitochondrial DNA NUMTS nuclear insertion flanking sequence VERTEBRATE

Origin and phylogenetic analysis of Tibetan Mastiff based on the mitochondrial DNA sequence被引量：15: 《Journal of Genetics and Genomics》2008年第6期335-340,共6页Qifa Li Zhenshan Liu Yinxia Li Xingbo Zhao Liyan Dong Zengxiang Pan Yuanrong Sun Ning Li Yinxue Xu Zhuang Xie; At present, the Tibetan Mastiff is the oldest and most ferocious dog in the world. However, the origin of the Tibetan Mastiff and its phylogenetic relationship with other large breed dogs such as Saint Bernard are unc...; 关键词：Tibetan Mastiff domestic dog mitochondrial DNA ORIGIN taxonomic status phylogenetic relationship

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