MITOCHONDRIAL_DNA

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Biological and translational attributes of mitochondrial DNA copy number:Laboratory perspective to clinical relevance
《World Journal of Methodology》2025年第3期38-55,共18页Deepak Parchwani Ragini Singh Digisha Patel 
The mitochondrial DNA copy number(mtDNAcn)plays a vital role in cellular energy metabolism and mitochondrial health.As mitochondria are responsible for adenosine triphosphate production through oxidative phosphorylati...
关键词：Mitochondrial DNA copy number Mitochondrial DNA Quantitative polymerase chain reaction Cancer Neurodegenerative disease AGING 
Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
《Neural Regeneration Research》2025年第6期1541-1554,共14页Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun Yuan Li Tifei Yuan Daihui Peng 
supported by the National Natural Science Foundation of China,No.81971269 (to DP);the Science and Technology Commission of Shanghai,No.YDZX20213100001003 (to DP)。
In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release f...
关键词：BIOMARKER cytokine EXOSOMES INFLAMMASOME major depressive disorder MICROGLIA mitochondrial DNA mitochondrial dysfunction NEUROINFLAMMATION Toll-like receptor 
A rare case of MELAS syndrome caused by mitochondrial DNA m.3256C>T mutation in China
《World Journal of Emergency Medicine》2025年第2期180-182,共3页Xiangxin Zheng Man Huang 
Mitochondrial cytopathies are characterized by energy failure within the cellular system.These disorders exhibit a wide range of clinical presentations and are highly heterogeneous.The mitochondrial diseases include m...
关键词：MELAS EPILEPSY clinical 
β‑Hydroxybutyrate‑induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy
《Journal of Animal Science and Biotechnology》2025年第2期653-667,共15页Yihui Huo Taiyu Shen Tianyin Feng Moli Li Wanli Zhao Juan JLoor Ben Aernouts Androniki Psifidi Chuang Xu 
supported by the National Natural Science Foundation of China(32125038);the National Key R&B Program of China(2023YFD1801100);China Agriculture Research System(CARS-36).
Background In perinatal dairy cows,ketosis is a prevalent metabolic disorder that lowers milk output and per-formance.Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood k...
关键词：AUTOPHAGY Bovine mammary gland Inflammation Mitochondria DNA 
Mitochondrial mt12361A>G increased risk of metabolic dysfunctionassociated steatotic liver disease among non-diabetes
《World Journal of Gastroenterology》2025年第10期38-50,共13页Ming-Ying Lu Yu-Ju Wei Chih-Wen Wang Po-Cheng Liang Ming-Lun Yeh Yi-Shan Tsai Pei-Chien Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yi-Hung Lin Tyng-Yuan Jang Ming-Yen Hsieh Zu-Yau Lin Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming-Lung Yu 
Supported by the“Center of Excellence for Metabolic Associated Fatty Liver Disease,National Sun Yat-sen University,Kaohsiung”,No.NSTC 112-2321-B-001-006;The Featured Areas Research Center Program within the Framework of the Higher Education Sprout Project by the Ministry of Education in Taiwan,No.MOHW112-TDU-B-221-124007.
BACKGROUND Insulin resistance,lipotoxicity,and mitochondrial dysfunction contribute to the pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD).Mitochondrial dysfunction impairs oxidative ph...
关键词：Metabolic dysfunction-associated steatotic liver disease Mitochondrial DNA Artificial intelligence Machine learning Algorithm 
Protective effects of probiotics against methotrexate-induced intestinal toxicity in the mice model
《BIOCELL》2025年第1期7-20,共14页KSENIA SSTAFEEVA NATALIA ASAMOYLOVA OLGA AKARANDEEVA VERONIKA VNESTEROVA KIRILL ASTARODUBTSEV EVGENY VMIKHAILOV ILYA OKRUTOV EVGENY SPOPOV NATALIA SRODIONOVA ANASTASIA VKOKINA ARTEM PGUREEV 
This research was carried out within the State Assignment of the Ministry of Science and Higher Education of the Russian Federation(project FZGW-2024-0003).
Objective:The objective of this study was to determine the level of methotrexate(MTX)toxicity in the intestines of mice and to evaluate the protective effect of probiotics composed of Streptococcus,Bifidobacterium,and...
关键词：Small intestine Mitochondrial DNA MITOCHONDRIA Il1b Trp53bp1 
A preliminary review on population parameters and genetic diversity in Oreochromis mossambicus:meta-regression and haplotype diversity
《Journal of Oceanology and Limnology》2024年第6期1943-1956,共14页Mehrnoush AMINISARTESHNIZI Ngonidzashe A.G.MOYO 
Assessment of population parameters and genetic diversity is critical for the economic and threatened species,including Oreochromis mossambicus.The morphometric and population parameters data for O.mossambicus were ex...
关键词：tilapia fish META-REGRESSION genetic diversity mitochondrial DNA population parameter Oreochromis mossambicus 
MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber’s hereditary optic neuropathy
《Science China(Life Sciences)》2024年第11期2511-2519,共9页Rui Wang Feixiang Bao Manjiao Lu Xiaoyun Jia Jiahui Xiao Yi Wu Qingjiong Zhang Xingguo Liu 
financially supported by the National Key Research and Development Program of China(2022YFE0210100,2023YFE0210100,2022YFA1103800,2019YFA0904500);the National Natural Science Foundation projects of China(32025010,92157202,32241002,92254301,92357302,32261160376,31970709,32070729,32100619,32170747,32322022,32370782,32371007,32300608,32300620);NSFC/RGC Joint Grant Scheme 2022/2023(N_CUHK 428/22);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003);International Cooperation Program,CAS(154144KYSB20200006);CAS Project for Young Scientists in Basic Research(YSBR-075);Guangdong Province Science and Technology Program(2023B0303000023,2023B1111050005,2023A1515030231,2022A1515110493,2023B1212060050,2021A1515012513,2021B1515020096,2022A1515012616,2022A1515110951,2023B1212120009,2024A1515010782,2024B1515040020,2024A1515030120);Guangzhou Science and Technology Program(202102021037,202102020827,202102080066,202206060002,2023A04J0414);Health@InnoHK funding support from the Innovation Technology Commission of the Hong Kong SAR,Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences;CAS Youth Innovation Promotion Association(to Y.W and K.C).
Leber’s hereditary optic neuropathy(LHON)is a debilitating mitochondrial disease associated with mutations in mitochondrial DNA(mtDNA).Unfortunately,the available treatment options for LHON patients are limited due t...
关键词：MITOCHONDRIA mitochondrial DNA mitochondrial diseases induced pluripotent stem cells stem cells METABOLISM energy mesenchymal stem cells 
Major depressive disorder is associated with mitochondrial ND6 T14502C mutation in two Han Chinese families
《World Journal of Psychiatry》2024年第11期1746-1754,共9页Pan Jing Hai-Hang Yu Ting-Ting Wu Bi-Hua Yu Ming Liang Ting-Ting Xia Xue-Wen Xu Ting Xu Ling-Jiang Liu Xiao-Bin Zhang 
Supported by the Zhejiang Medical and Health Science and Technology Project,No.2023KY1126;Suzhou Key Technologies Program,No.SKY2021063;Jiangsu Province Social Development Project,No.BE2020764;Suzhou Clinical Medical Center for Mood Disorders,No.Szlcyxzx202109;Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116;Suzhou Key Laboratory,No.SZS2024016。
BACKGROUND Globally,the World Health Organization ranks major depressive disorder(MDD)as the leading cause of disability.However,MDD molecular etiology is still poorly understood.AIM To explore the possible associatio...
关键词：Major depressive disorder Mitochondrial DNA ND6 T14502C MUTATION HAPLOGROUP CHINESE 
Molecular evaluation of Conogethes punctiferalis(Guenée,1854):Species status and intraspecific divergence
《Zoological Systematics》2024年第3期267-275,共9页Jin An Yalin Yao Ping Gao Minghua Xiu Chengmin Shi 
This study was supported by a starting fund from Hebei Agricultural University and the State Key Laboratory of North China Crop Improvement and Regulation(YJ2020028).
Species are not only the fundamental units of taxonomy but also the basic units of pest management.Insects of Conogethes are important agricultural and forestry pests.However,species boundaries within Conogethes often...
关键词：Species delimitation DNA barcoding genetic distances mitochondrial DNA 
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