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Allotopic expression of mitochondrial genes:Basic strategy and progress被引量：1
《Genes & Diseases》2020年第4期578-584,共7页I.Made Artika 
Allotopic expression of mitochondrial genes is a deliberate functional relocation of mitochondrial genes into the nucleus followed by import of the gene-encoded polypeptide from the cytoplasm into the mitochondria.For...
关键词：Allotopic expression Gene therapy MITOCHONDRIA Mitochondrial gene Protein targeting 
Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth被引量：1
《Genes & Diseases》2022年第3期717-730,共14页Daqian Zhan Fatih Yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye John Laterra Mingyao Ying Hernando Lopez-Bertoni Shuli Xia 
This work was supported by grants from NIH R01NS091165(S.X.),R01 NS099460(M Ying),R01 NS096754(J Laterra),and R01 NS076759(J Laterra)。
Glioblastoma(GBM,WHO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal prognosis.The extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,mig...
关键词：4-MU Extracellular matrix(ECM) Glioblastoma(GBM) Hyaluronic acid(HA) PHAGOCYTOSIS T cells Tumor-associated microglia/macrophages(TAMs) UGDH 
The regulatory role of m^(6)A modification in the maintenance and differentiation of embryonic stem cells
《Genes & Diseases》2024年第5期126-139,共14页Jin Zhang Lingling Tong Yuchen Liu Xiang Li Jiayi Wang Ruoxin Lin Ziyu Zhou Yunbing Chen Yanxi Chen Yirong Liu Di Chen 
the National Natural Science Foundation of China(No.32270835 to DC);the Zhejiang Natural Science Foundation(No.Z22C129553 to DC).
As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs,N6-methyladenosine(m^(6)A)post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biologica...
关键词：Cell-fate transition Embryonic stem cell Epigenetic modification m^(6)A modification Post-transcriptional regulation 
Reversible N6-methyladenosine of RNA:The regulatory mechanisms on gene expression and implications in physiology and pathology被引量：4
《Genes & Diseases》2020年第4期585-597,共13页Xinyu Fang Mengyang Li Tao Yu Gaoli Liu Jianxun Wang 
This work was supported by Taishan Scholar Program of Shandong Province(tsqn201812044);Natural Science Foundation of Shandong Province(JQ201815);National Natural Science Foundation of China(81900259).
N6-methyladenosine(m6A)is the most abundant inner RNA modification in eukaryotes.Due to the development of RNA sequencing technology,the distribution pattern of m6A in the transcriptome has been uncovered.Dynamically,...
关键词：DISEASES EPIGENETICS Gene expression m6A m6A regulator RNA 
Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells
《Genes & Diseases》2022年第3期731-740,共10页Renke Tan Wenhao Du Yiyang Liu Xiaoji Cong Meirong Bai Chenxiao Jiang Zengxia Li Minjia Tan Dengke K.Ma Qiang Huang Wei Jiang Yongjun Dang 
This work was supported by the National Key Research and Development Program of China(No.2018YFC0310900);the National Natural Science Foundation of China grants(No.31270830,21572038,21877016 to Y.D,No.31671386 to Q.H,81972621 to W.J);the Development Fund for Shanghai Talents,Fund of State Key Laboratory of Bioorganic and Natural Products Chemistry,Fund of State Key Laboratory of Drug Research,Chinese Academy of Science(No.SIMM1601KF-08);Fudan University Graduate Student Research Grant.
The CRISPR/Cas9 system,originally derived from the prokaryotic adaptive immune system,has been developed as efficient genome editing tools.It enables precise gene manipulation on chromosomal DNA through the specific b...
关键词：CRISPR/Cas9 Gene editing Global transcription Nucleolus detention signal TRANSLATION 
Exploiting the potential of the ubiquitin-proteasome system in overcoming tyrosine kinase inhibitor resistance in chronic myeloid leukemia
《Genes & Diseases》2024年第5期140-162,共23页Xudong Li Wei Li Yanli Zhang Linping Xu Yongping Song 
The advent of tyrosine kinase inhibitors(TKI)targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia(CML),greatly prolonged the life of CML patients,and improved their prognosis.Ho...
关键词：Chronic myeloid leukemia Deubiquitinases E3 ligase PROTAC TKI resistance Ubiquitin-proteasome system 
The functions of N6-methyladenosine modification in lncRNAs被引量：3
《Genes & Diseases》2020年第4期598-605,共8页Rong-Zhang He Jing Jiang Di-Xian Luo 
This work was supported by the Natural Science Foundation of China(81773165);Hunan Province Science Fund for Distinguished Young Scholars(2018JJ1021);the Key R&D Program of Hunan Province(2017SK2172);the Science and Technology Foundation of Chenzhou(jsyf2017023).
Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications.Among them,N6-methyladenosine(m6A),which has been shown to play key roles in RNA splicing,stability,nuclear export,and tr...
关键词：Erasers LncRNA N6-methyladenosine READERS WRITERS 
The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP 1 activity via RhoA被引量：1
《Genes & Diseases》2022年第3期741-752,共12页Xing Du Yunsheng Ou Muzi Zhang Kai Li Wei Huang Dianming Jiang 
This work was supported by the Natural Science Foundation of Chongqing(No.cstc2019jcyj-msxmX0358).
Osteosarcoma is the most common malignant bone tumour,and the metastasis of osteosarcoma is an important cause of death.Evidence has shown that the mevalonate pathway is highly activated and is expected to be a new ta...
关键词：METASTASIS Mevalonate pathway OSTEOSARCOMA RHOA YAP1 
Epigenetic regulation of prostate cancer被引量：2
《Genes & Diseases》2020年第4期606-613,共8页Ruixin Wang Xiaoqi Liu 
NIH R01 CA157429(X.Liu);R01 CA192894(X.Liu);R01 CA196835(X.Liu);R01 CA196634(X.Liu);The work was also partially supported by University of Kentucky Cancer Center(P30 CA177558).
Prostate cancer is(PCa)the second leading cause of cancer death in males in the United State,with 174,650 new cases and 31,620 deaths estimated in 2019.It has been documented that epigenetic deregulation such as histo...
关键词：DNMT EPIGENETICS EZH2 HDAC PHOSPHORYLATION Prostate cancer 
Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension被引量：2
《Genes & Diseases》2022年第3期753-765,共13页Ruiyu Wang Yongzheng Guo Lingjiao Li Minghao Luo Linqian Peng Dingyi Lv Zhe Cheng Qian Xue Liang Wang Jing Huang 
The work was supported by the National Natural Science Foundation of China(No.81370440);the National Science-Technology Support Projects of China(No.2015BAI01B00).
Excessive oxidative stress is a major causative factor of endothelial dysfunction in hypertension.As an endogenous pro-oxidant,thioredoxin-interacting protein(TXNIP)contributes to oxidative damage in various tissues.T...
关键词：Endothelial dysfunction ENOS HYPERTENSION Oxidative stress Thioredoxininteracting protein 
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