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检索条件："刊名=Synthetic and Systems Biotechnology "
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Engineered polyketides:Synergy between protein and host level engineering被引量：4
《Synthetic and Systems Biotechnology》2017年第3期147-166,共20页Jesus F.Barajas Jacquelyn M.Blake-Hedges Constance B.Bailey Samuel Curran Jay.D.Keasling 
This work was funded by the Joint BioEnergy Institute(JBEI),which is funded by the U.S.Department of Energy,Office of Science,Office of Biological and Environmental Research,under Contract DE-AC02-05CH11231;by the National Science Foundation under awards MCB-1442724,NSF-GRFP DGE-1106400 and CBET-1437775;as part of the Co-Optimization of Fuels&Engines(Co-Optima)project sponsored by the U.S.Department of Energy(DOE)Office of Energy Efficiency and Renewable Energy(EERE);Bioenergy Technologies and Vehicle Technologies Offices,and by the DOE Agile-Biofoundry(https://agilebiofoundry.org)supported by the U.S.Department of Energy,Energy Efficiency and Renewable Energy,Bioenergy Technologies Office,through contract DE-AC02-05CH11231 between Lawrence Berkeley National Laboratory and the U.S.Department of Energy.The United States Government retains and the publisher,by accepting the article for publication,acknowledges that the United States Government retains a nonexclusive,paid-up,irrevocable,world-wide license to publish or reproduce the published form of this manuscript,or allowothers to do so,for United States Government purposes.Additional funding was provided by the National Science Foundation Graduate Research Fellowship under Grant No.(DGE 1106400).
Metabolic engineering efforts toward rewiring metabolism of cells to produce new compounds often require the utilization of non-native enzymatic machinery that is capable of producing a broad range of chemical functio...
关键词：POLYKETIDE Polyketide synthase Natural products Commodity chemical Metabolic engineering Synthetic biology 
Metabolic engineering for the microbial production of isoprenoids:Carotenoids and isoprenoid-based biofuels被引量：8
《Synthetic and Systems Biotechnology》2017年第3期167-175,共9页Fu-Xing Niu Qian Lu Yi-Fan Bu Jian-Zhong Liu 
the National Natural Science Foundation of China(Grant NO.21276289);the Natural Science Foundation of Guangdong Province(NO.2015A030311036);the Project of the Scientific and Technical Program of Guangdong Province(NO.2015A010107004);the Project of the Scientific and Technical Program of Guangzhou(NO.201607010028)for their financial support.
Isoprenoids are the most abundant and highly diverse group of natural products.Many isoprenoids have been used for pharmaceuticals,nutraceuticals,flavors,cosmetics,food additives and biofuels.Carotenoids and isoprenoi...
关键词：Carotenoids Isoprenoid-based biofuel Metabolic engineering Synthetic biology 
Transcription control engineering and applications in synthetic biology被引量：6
《Synthetic and Systems Biotechnology》2017年第3期176-191,共16页Michael D.Engstrom Brian F.Pfleger 
MDE was supported by an NHGRI training grant to the Genomic Sciences Training Program 5T32-HG002760;BFP was supported by a grant from the National Science Foundation(EFRI-1240268).
In synthetic biology,researchers assemble biological components in new ways to produce systems with practical applications.One of these practical applications is control of the flow of genetic information(from nucleic...
关键词：PROMOTER TRANSCRIPTION Synthetic biology BACTERIA TERMINATION Metabolic engineering 
Engineering bacteria for enhanced polyhydroxyalkanoates(PHA)biosynthesis被引量：11
《Synthetic and Systems Biotechnology》2017年第3期192-197,共6页Guo-Qiang Chen Xiao-Ran Jiang 
This research was financially supported by a grant from Ministry of Sciences and Technology(Grant No.2016YFB0302504);grants from National Natural Science Foundation of China(Grant No.31430003);Tsinghua President Fund also supported this project(Grant No.2015THZ10).
Polyhydroxyalkanoates(PHA)have been produced by some bacteria as bioplastics for many years.Yet their commercialization is still on the way.A few issues are related to the difficulty of PHA commercialization:namely,hi...
关键词：PHB POLYHYDROXYALKANOATES EXTREMOPHILES HALOPHILES Next generation industrial biotechnology NGIB Metabolic engineering Pathway engineering Morphology engineering Contents 
Genome and metabolic engineering in non-conventional yeasts:Current advances and applications被引量：5
《Synthetic and Systems Biotechnology》2017年第3期198-207,共10页Ann-Kathrin Lobs Cory Schwartz Ian Wheeldon 
This work was supported by NSF CBET-1510697 and -1403264.
Microbial production of chemicals and proteins from biomass-derived andwaste sugar streams is a rapidly growing area of research and development.While the model yeast Saccharomyces cerevisiae is an excellent host for ...
关键词：CRISPR-Cas9 Kluyveromyces lactis Kluyveromyces marxianus Scheffersomyces stipitis Yarrowia lipolytica Hansenula polymorpha Pichia pastoris 
Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes,with applications in synthetic biology被引量：4
《Synthetic and Systems Biotechnology》2017年第3期208-218,共11页Chun You Rui Huang Xinlei Wei Zhiguang Zhu Yi-Heng Percival Zhang 
This study was mainly supported by the Key Research Program of the Chinese Academy of Sciences(Grant No.ZDRW-ZS-2016-3);1000-youth program of China to CY and the National Natural Science Foundation of China(Grant No.31600636);Funds were partially provided by the DOE EERE award(DE-EE0006968)to YPZ.
Two natural nicotinamide-based coenzymes(NAD and NADP)are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism,respectively.Most NAD(P)-dependent oxidoreductases prefer one coenz...
关键词：Coenzyme engineering Nicotinamide-based coenzymes NAD NADP Protein engineering Synthetic biology Biomimetic coenzymes 
Fundamental CRISPR-Cas9 tools and current applications in microbial systems被引量：7
《Synthetic and Systems Biotechnology》2017年第3期219-225,共7页Pingfang Tian Jia Wang Xiaolin Shen Justin Forrest Rey Qipeng Yuan Yajun Yan 
This work was supported by grants from National Natural Science Foundation of China(No.21276014,21476011);National High Technology Research and Development Program(863 Program)(No.2015AA021003);Fundamental Research Funds for the Central Universities(YS1407);111 project(B13005).
Derived from the bacterial adaptive immune system,CRISPR technology has revolutionized conventional genetic engineering methods and unprecedentedly facilitated strain engineering.In this review,we outline the fundamen...
关键词：CRISPR-Cas9 CRISPR interference CRISPR activation DNA repair Homologous recombination 
Polygalacturonase-inhibiting proteins as an exogenously applied natural solution for prevention of postharvest fungal infections
《Synthetic and Systems Biotechnology》2024年第3期481-493,共13页Tiffany Chiu Yanran Li 
Polygalacturonase inhibiting proteins(PGIPs)are plant proteins involved in the inhibition of polygalacturonases(PGs),cell-wall degrading enzymes often secreted by phytopathogenic fungi.Previously,we confirmed that PGI...
关键词：PGIP Antifungal agent Pest control Postharvest treatment 
ECMpy 2.0:A Python package for automated construction and analysis of enzyme-constrained models
《Synthetic and Systems Biotechnology》2024年第3期494-502,共9页Zhitao Mao Jinhui Niu Jianxiao Zhao Yuanyuan Huang Ke Wu Liyuan Yun Jirun Guan Qianqian Yuan Xiaoping Liao Zhiwen Wang Hongwu Ma 
the National Key Research and Development Program of China(2021YFC2100700);National Natural Science Foundation of China(32300529,32201242,12326611);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIPPTJS-001,TSBICIP-PTJS-002,TSBICIP-PTJJ-007);Major Program of Haihe Laboratory of Synthetic Biology(22HHSWSS00021);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000).
Genome-scale metabolic models(GEMs)have been widely employed to predict microorganism behaviors.However,GEMs only consider stoichiometric constraints,leading to a linear increase in simulated growth and product yields...
关键词：Enzyme-constrained model Python package Automated construction Multiple analysis functions 
Site-directed mutagenesis of bifunctional riboflavin kinase/FMN adenylyltransferase via CRISPR/Cas9 to enhance riboflavin production
《Synthetic and Systems Biotechnology》2024年第3期503-512,共10页Bing Fu Meng Chen Xianfeng Bao Jiajie Lu Zhiwen Zhu Fuyao Guan Chuyang Yan Peize Wang Linglin Fu Ping Yu 
the Natural Science Foundation of Zhejiang Province,China(No.LY21C200006)。
Vitamin B_(2)is an essential water-soluble vitamin.For most prokaryotes,a bifunctional enzyme called FAD synthase catalyzes the successive conversion of riboflavin to FMN and FAD.In this study,the plasmid pNEW-AZ cont...
关键词：Vitamin B_(2) FAD synthase Escherichia coli BL21 Riboflavin kinase CRISPR/Cas9 
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