国家重点基础研究发展计划(2007CB936000)

作品数:28被引量:75H指数:5
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相关作者:唐波佟丽丽徐克花崔官伟禚林海更多>>
相关机构:山东师范大学中国科学院上海应用物理研究所浙江大学上海交通大学更多>>
相关期刊:《Chinese Physics B》《核技术》《Science Bulletin》《物理》更多>>
相关主题:GRAPHENE_OXIDECATALYSIS荧光探针GRAPHENE细胞成像更多>>
相关领域:理学生物学一般工业技术医药卫生更多>>
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人工纳米生物机器构筑与生物医学应用的基础研究
《中国科技成果》2014年第2期57-57,共1页
国家重点基础研究发展计划(973计划)项目(2007CB936000).
分子机器是纳米科学技术的一个梦想。 与现有的生物型分子机器以及人工分子机器概念不同,本项目提出一种杂合型的机器——“人工纳米生物机器”,通过设计把人工纳米结构与具有不同功能的生物分子有机集成起来,二者互相配合,期望能...
关键词:分子机器 纳米生物 人工 基础研究 生物医学 应用 纳米科学技术 高级功能 
Mechanical force-induced DNA damage during AFM single-molecule manipulation
《Nuclear Science and Techniques》2013年第3期66-71,共6页ZHANG Chen DUAN Na DAI Bin ZHANG Yi ZHANG Donghua HU Jun 
Supported by National Basic Research Program of China(973 Program Nos.2007CB936000 and 2012CB932600);National Natural Science Foundation of China(No.21073222);Chinese Academy of Sciences(No.KJCX2-EW-N03)
Many environmental factors can cause DNA damage, such as radiation, heat, oxygen free radical, etc., which can induce mutation during DNA replication. Meanwhile, DNA molecules are subjected to various mechanical force...
关键词:原子力显微镜 DNA损伤 单分子操纵 机械力 诱导 DNA突变 DNA复制 聚合酶链反应 
High-conductivity graphene nanocomposite via facile,covalent linkage of gold nanoparticles to graphene oxide被引量:1
《Chinese Science Bulletin》2012年第23期3086-3092,共7页ZHANG YuJie GENG MaKe ZHANG Huan HE Yao PENG Cheng HUANG Qing FAN ChunHai 
supported by the National Natural Science Foundation of China(20725516,90913014,10975179);the National Basic Research Program of China(2007CB936000);Ministry of Health(2009ZX10004-301);Shanghai Municipal Commission for Science and Technology(0952nm04600)
Graphene and its derivative,graphene oxide (GO) have been substantively used as the main framework for dispersing or building nanoarchitectures because of their excellent properties in electronics and catalysis.The re...
关键词:GRAPHENE oxide gold nanoparticles NANOCOMPOSITE Michael addition reaction 
Peptide friction in water nanofilm on mica surface
《Chinese Physics B》2012年第2期431-436,共6页Zhou Bo Xiu Peng Wang Chun-Lei Fang Hai-Ping 
supported by the National Natural Science Foundation of China (Grant No.10825520);the National Basic Research Program of China (Grant No.2007CB936000);the National Science Foundation for Post-Doctoral Scientists of China (Grant No.20100480645)
Peptide frictions in water nanofilms of various thicknesses on a mica surface are studied via molecular dynamics simulations. We find that the forced lateral motion of the peptide exhibits stick-slip behaviour at low ...
关键词:peptide friction water nanofilm mica surface molecular dynamics simulation 
Local and global sensitivity analysis of PCR kinetic model
《Nuclear Science and Techniques》2012年第2期124-128,共5页LI Lanting MI Lijuan HU Jun 
Supported by the Shanghai Municipal Commission for Science and Technology (09395811700);National Basic Research Program of China (2007CB936000)
A mathematical model of polymerase chain reaction (PCR) containing uncertain and time-varying parameters has become important for model-based guidance experiment design. In this study, the local and global sensitivity...
关键词:敏感性分析 PCR 动力学模型 聚合酶链反应 反应速率常数 反应物浓度 非特异性反应 变参数模型 
石墨烯与双链DNA分子复合结构电导性的c-AFM研究
《核技术》2012年第2期141-145,共5页牛冬校 胡钧 
国家自然科学基金(10874198;90923002;21073222;10975175;10874030)项目;国家重点基础研究973项目(2007CB936000);中国科学院基金(KJCX2-EW-N03)的资助和支持
利用导电原子力显微镜(conductive atomic force microscope,c-AFM)的扭转共振隧穿电流模式,在绝缘衬底云母上对还原石墨烯(rGO)和DNA构成的复合体导电性做了初步的测量。测量结果表明,石墨烯能很好地吸附双链DNA分子形成连接复合体,c-...
关键词:导电原子力显微镜 石墨烯 脱氧核糖核酸 电子输运 分子器件 
A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells被引量:4
《Chinese Science Bulletin》2011年第31期3260-3265,共6页GONG Wei SU RuiXian LI Lu XU KeHua TANG Bo 
supported by the National Basic Research Program of China (2007CB936000);the National Natural Science Foundation of China (20875057);the National Natural Science Funds for Distinguished Young Scholar (20725518);the National Key Natural Science Foundation of China (21035003);the Science and Technology Development Programs of Shandong Province of China (2008GG30003012);the Key Natural Science Foundation of Shandong Province of China (ZR2010BZ001)
In this study, we have designed and synthesized a new near-infrared (NIR) fluorescent probe (BODIPY-Se) to detect fluorine ions (F-) using a B-Se bond to connect the fluorescent dye BODIPY and benzotrifluoride. The pr...
关键词:HEPG2细胞 荧光探针 近红外 氟离子 细胞成像 应用 肾上腺素 荧光染料 
Proteomic profiling of hepatitis B virus-related hepatocellular carcinoma with magnetic bead-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry被引量:1
《Acta Biochimica et Biophysica Sinica》2011年第7期542-550,共9页Taotao Liu Ruyi Xue Xiaowu Huang Danying Zhang Ling Dong Hao Wu Xizhong Shen 
This study was supported by the grants from the National Basic Research Program of China (2007CB936000), Major National Science and Technology Projects (2009ZX10004-301 and 2008ZX10002-017), Shanghai Science and Technology Commission (10410709400 and 104119 50100), Shanghai Talent Development Foundation (2009-035), and National Natural Science Foundation of China (30772505, 30872503 and 81000968).
Proteomic techniques are promising strategies in the surveillance of hepatocellular carcinoma (HCC). This study aimed to investigate the serum profiling with magnetic bead (MB) and matrix-assisted laser desorption...
关键词:BIOMARKER hepatocellular carcinoma hepatitis B virus MALDI-TOF MS 
Adsorption of sodium ions and hydrated sodium ions on a hydrophobic graphite surface via cation-π interactions
《Chinese Physics B》2011年第6期474-479,共6页石国升 王志刚 赵纪军 胡钧 方海平 
Project supported by the National Natural Science Foundation of China (Grant Nos. 10674146 and 10825520);the National Basic Research Program of China (Grant No. 2007CB936000);the Knowledge Innovation Program of the Chinese Academy of Sciences
Using density functional theory computation, we show that sodium ions and hydrated sodium ions can be strongly adsorbed onto a hydrophobic graphite surface via cation-π interactions. The key to this eation-π interac...
关键词:GRAPHITE sodium ion and hydrated sodium ion cation-π interaction density functional theory 
Influencing factors on local reduction of graphene oxide with a heated AFM tip被引量:1
《Nuclear Science and Techniques》2011年第4期245-250,共6页WU Zhongliang SHEN Yue ZHOU Xingfei GUO Shouwu ZHANG Yi 
supported by National Basic Research Program of China (No. 2007CB936000);Chinese Academy of Sciences (No. KJCX2-EW-N03);National Science Foundation of China (No. 10975175,90923002,and 90923041)
In this paper,the factors influencing the local thermal reduction of graphene oxide (GO) sheets are investigated.The lateral force microscopy and scanning polarization force microscopy verify that the heated tips of a...
关键词:石墨氧化物 影响因素 针尖 原子力显微镜 纳米结构 加热时间 环境湿度 热还原 
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