国家自然科学基金(31271378)

作品数：7被引量：194H指数：5
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SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs被引量：15
《Cell Research》2021年第3期247-258,共12页Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang 
This work was supported by the National Key R&D Program of the Ministry of Science and Technology(2018YFA0507100);the Science and Technology Major Project of China(2015ZX09102023-003);the National Basic Research Program of China(973 Program;2014CB542300 and 2012CB517603);the National Natural Science Foundation of China(81250044,81101330,31271378 and 81602697);the Fundamental Research Funds for the Central Universities(020814380018,020814380130,020814380133 and 020814380146).
Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is requi...
关键词：STOMACH IMPAIRED protective 
Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses被引量：119
《Cell Research》2015年第1期39-49,共11页Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang 
We thank Dr Zheng-Gang Liu （Cancer Research Institute, NIH） and Dr Dan Wu （Yale University） for their comments on the manuscript. This work was supported by the National Basic Research Program of China （973 Program; 2014CB542300）, the National Natural Science Foundation of China （81101330, 31271378 and 81250044）, the Natural Science Foundation of Jiangsu Province （BK2011013, BK2012014 and BK20130592） and the Research Special Fund for Public Welfare Industry of Health （201302018）.
Influenza A viruses （IAVs）, particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle （HS）-encoded atypical microRNA, directly targets IAVs...
关键词：MICRORNA influenza A virus H1N1 H5N1 H7N9 HONEYSUCKLE MIR2911 
Tumor-secreted miR-214 induces regulatory T cells： a major link between immune evasion and tumor growth被引量：36
《Cell Research》2014年第10期1164-1180,共17页Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang 
We thank ProfAlexander Rudensky （Memorial Sloan-Kettering Cancer Center, New York） for diphtheria toxin-treated Foxp3DrR mice. We thank Drs Zheng-Gang Liu （Cancer Research Institute, NIH） and Dan Wu （Yale University） for their comments on the manuseirpt. This work was supported by grants from the National Basic Research Program of China （973 Program; 2014CB542300）, the National Natural Science Foundation of China （81101330, 31271378 and 81250044）, the Natural Science Foundation of Jiangsu Province （BK2011013 and BK2012014） and the Research Special Fund for Public Welfare Industry of Health （201302018）. This work was also supported by the program for New Century Excellent Talents in University from the Ministry of Education of China （NCET- 12-0261）.
An increased population of CD4＋CD25highFoxp3＋ regulatory T cells （Tregs） in the tumor-associated microenvi- ronment plays an important role in cancer immune evasion. However, the underlying mechanism remains uncle...
关键词：secreted microRNA regulatory T cell PTEN MICROVESICLE immune evasion TUMOR 
Identification of Ebola virus microRNAs and their putative pathological function被引量：5
《Science China(Life Sciences)》2014年第10期973-981,共9页LIANG HongWei ZHOU Zhen ZHANG SuYang ZEN Ke CHEN Xi ZHANG ChenYu 
supported by the National Basic Research Program of China(2014CB542300);the National Natural Science Foundation of China(81101330,31271378,81250044);the Natural Science Foundation of Jiangsu Province(BK2012014);the Research Special Fund for Public Welfare Industry of Health(201302018);supported by the Program for New Century Excellent Talents in University from Ministry of Education of China(NCET-12-0261)
Ebola virus(EBOV),a member of the filovirus family,is an enveloped negative-sense RNA virus that causes lethal infections in humans and primates.Recently,more than 1000 people have been killed by the Ebola virus disea...
关键词：MICRORNA Ebola virus FUNCTION 
MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons被引量：2
《Protein & Cell》2014年第2期160-169,共10页Hanqin Li Susu Mao Haitao Wang Ke Zen Chenyu Zhang Liang Li 
This work was supported by grants from the National Natural Science Foundation of China （Grant Nos. 31000478, 31100777 and 31271378）.
MicroRNAs （miRNAs） are endogenously expressed small, non-coding transcripts that regulate protein expression. Substantial evidences suggest that miRNAs are enriched in central nervous system, where they are hypothes...
关键词：MiRNAs are approximately 21 nucleotide non-codingtranscripts that are derived from hairpin precursors which 
Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF,and the neutralization of miR-150 attenuate tumor development被引量：19
《Protein & Cell》2013年第12期932-941,共10页Yuchen Liu Luming Zhao Dameng Li Yuan Yin Chen-Yu Zhang Jing Li Yujing Zhang 
This work was supported by grants from the National Basic Research Program(973 Program)(No.2014CB542300);the National Natural Science Foundation of China(Grant Nos.31200969,31200874,81101330,31271378,and 81250044);the National Science Fund for Distinguished Young Scholars(81025019);the Natural Science Foun-dation of Jiangsu Province(BK2011013 and BK2012014);the Research Fund for the Doctoral Program of Higher Education of China(20120091120044).
Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic facto...
关键词：MICROVESICLE miR-150 TUMORIGENESIS VEGF NEUTRALIZATION ATTENUATION 
Nuclear microRNAs and their unconventional role in regulating non-coding RNAs被引量：6
《Protein & Cell》2013年第5期325-330,共6页Hongwei Liang Junfeng Zhang Ke Zen Chen-Yu Zhang Xi Chen 
supported by grants from the National Natural Science Foundation of China(Grant Nos.81101330,31271378,81250044 and J1103512);the Natural Science Foundation of Jiangsu Province(Nos.BK2011013 and BK2012014).
MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that are involved in post-transcriptional gene regulation. It has long been assumed that miRNAs exert their roles only in the cytoplasm, where they recognize their...
关键词：MICRORNA nuclear microRNA non-coding RNA nucleus ARGONAUTE EXPORTIN IMPORTIN 
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