EXPORTIN

作品数:13被引量:17H指数:2
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相关领域:医药卫生生物学更多>>
相关作者:陈宁仝进毅张杰张杰王竹青更多>>
相关机构:浙江大学医学院附属妇产科医院杭州市第一人民医院上海海洋大学中国水产科学研究院黄海水产研究所更多>>
相关期刊:《国际消化病杂志》《渔业科学进展》《Journal of Cancer Therapy》《Cellular & Molecular Immunology》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划中国水产科学研究院基本科研业务费专项基金广东省自然科学基金更多>>
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Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through ERK1/2 nuclear export被引量:1
《Cellular & Molecular Immunology》2024年第8期873-891,共19页Saeed Daneshmandi Qi Yan Jee Eun Choi Eriko Katsuta Cameron R.MacDonald Mounika Goruganthu Nathan Roberts Elizabeth A.Repasky Prashant K.Singh Kristopher Attwood Jianmin Wang Yosef Landesman Philip L.McCarthy Hemn Mohammadpour 
National Institutes of Health,National Heart Lung Blood Institute(K99 HL155792,R00HL155792 to HM);Roswell Park Alliance(HM),a gift from Brendan and Elise McCarthy(PLM),and R01 CA205246(ER);Cytometry services were provided by the Flow and Image Cytometry Shared Resource at the Roswell Park Comprehensive Cancer Center,which is supported in part by the NCI Cancer Center Support Grant NCI R50CA211108;NCI grant P30CA016056 involving the use of Roswell Park Comprehensive Cancer Center’s Genomic and Flow and Image Cytometry Shared Resources.Selinexor was provided by Karyopharm,Newton,MA.
Myeloid-derived suppressor cells(MDSCs)are a main driver of immunosuppression in tumors.Understanding the mechanisms that determine the development and immunosuppressive function of these cells could provide new thera...
关键词:MDSCS TUMOR Exportin 1 MAPK pathway 
Exportin家族鉴定及其在尼罗罗非鱼中的表达分析
《西南大学学报(自然科学版)》2024年第1期77-86,共10页张清清 游慧芹 杜康 陶文静 
国家自然科学基金面上项目(31972778);西南大学大学生创新创业训练计划项目(S202110635298).
输出蛋白(Exportins,XPOs)负责细胞核中蛋白质和RNA的输出,对基因表达调控起着重要的作用,然而Exportin家族的系统进化和表达模式尚不清楚.研究首先对22种代表性动物的Exportin家族进行鉴定并分析了其系统进化,再通过转录组分析和qRT-PC...
关键词:输出蛋白 系统进化分析 表达分析 尼罗罗非鱼 
The nuclear export receptor OsXPO1 is required for rice development and involved in abiotic stress responses
《The Crop Journal》2023年第1期71-78,共8页Qiufei Peng Jieyu Qiu Xintong Li Xuezhong Xu Xinxiang Peng Guohui Zhu 
supported by the National Key Research and Development Program(2020YFA0907600);the Laboratory of Lingnan Modern Agriculture Project(NZ2021004);the Natural Science Foundation of Guangdong Province(2020A1515010157);the Science and Technology Program of Guangzhou(202102080499)。
The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.Nucleocytoplasmic trafficking of pro...
关键词:Exportin 1 Nucleocytoplasmic transport Plant development Abiotic stress 
EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulating nucleo-cytoplasmic partitioning of HDA6
《Journal of Integrative Plant Biology》2019年第12期1243-1254,共12页Guohui Zhu Yanan Chang Xuezhong Xu Kai Tang Chunxiang Chen Mingguang Lei Jian-Kang Zhu Cheng-Guo Duan 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27040203);supported by Chinese Academy of Sciences;supported by the National Natural Science Foundation of China(31570250)
In eukaryotic cells,transport of macromolecules across the nuclear envelope is an essential process that ensures rapid exchange of cellular components,including protein and RNA molecules.Chromatin regulators involved ...
关键词:ENVELOPE RETENTION EXCHANGE 
宫颈脱落细胞Ki67和exportin-5表达用于宫颈癌筛查的初步研究被引量:4
《中国卫生检验杂志》2019年第12期1427-1430,共4页姚珊瑚 陈宁 刘维娜 仝进毅 
浙江省自然科学项目(LY12H16018)
目的探讨宫颈脱落细胞中 Ki67 和 exportin-5 的表达用于宫颈癌筛查的价值。方法 3 000 例同时行液基薄层细胞学检查( TCT)和杂交捕获Ⅱ代法人乳头瘤病毒( HPV HC -Ⅱ)检测的患者,按 TCT 结果分为 4 组,采用免疫荧光双标法检测各组宫颈...
关键词:宫颈癌 KI67 EXPORTIN - 5 筛查价值 
Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kαinhibition in breast cancer被引量:1
《Signal Transduction and Targeted Therapy》2019年第1期211-213,共3页Xue-Ling Liu Bo-Bo Wang Yi Wang Yu-Xiang Wang Chun-hao Yang Cun Tan Xi Zhang Qiao-jun He Jian Ding Ling-Hua Meng 
Dear Editor,Targeting PI3K is a promising approach for cancer therapy,and the PI3Kα-selective inhibitor alpelisib has been approved for breast cancer treatment.1,2,3 However,the development of acquired resistance pos...
关键词:PI3K BREAST cancer 
三疣梭子蟹Drosha和Exportin 5基因克隆及其在性腺发育过程中的表达分析被引量:1
《渔业科学进展》2018年第3期126-136,共11页张小辉 孟宪亮 高保全 刘萍 王竹青 张杰 蔡影 
国家自然科学基金项目(41576147;41306178);泰山领军人才工程高效生态农业创新类计划项目(LJNY2015002);中国水产科学研究院基本科研业务费(2018HY-ZD0201)共同资助~~
本研究利用RACE技术克隆了三疣梭子蟹(Portunus trituberculatus)Drosha和Exportin 5基因的cDNA全长序列,Drosha基因长度为3443 bp,编码1038个氨基酸,预测蛋白质包含2个相邻的RNA酶Ⅲ结构域(RⅢDa和RⅢDb)和1个双链RNA结合结构域(dsRBD)...
关键词:三疣梭子蟹 DROSHA Exportin5 基因克隆 基因表达 
Circadian Rhythms in Doxorubicin Nuclear Uptake and Clock Control of C6 Glioma Cells
《Journal of Cancer Therapy》2016年第8期558-572,共15页Ashapurna Sarma Vishal P. Sharma Michael E. Geusz 
Alterations of drug efficacy by the circadian clock are a concern when assessing drug therapies. Circadian rhythms persist in some cancer cells and are repressed in others. A better understanding of circadian activiti...
关键词:Nucleocytoplasmic Transport Circadian Pacemaker GLIOBLASTOMA EXPORTIN CHEMOTHERAPY 
巴西橡胶树importin和exportin基因的克隆及其乙烯响应规律分析
《热带亚热带植物学报》2016年第3期243-251,共9页冯伟强 仝征 靳翔 王丹 孙勇 蒙雪茹 王旭初 
国家自然科学基金面上项目(31270712);国家自然科学基金项目(31400523);海南省重大科技专项(ZDZX2013023-1)资助~~
为了解巴西橡胶树(Hevea brasiliensis)中importin和exportin基因的功能,采用RACE技术从巴西橡胶树中克隆了他们的c DNA全长,分别命名为Hb IMP和Hb XPO。结果表明,Hb IMP全长4170 bp,编码1115个氨基酸;Hb XPO全长4108 bp,编码1081个氨...
关键词:巴西橡胶树 乙烯 核质转运蛋白 基因克隆 
MicroRNA生物合成相关基因在肝癌中的表达及其意义被引量:1
《国际消化病杂志》2013年第3期193-196,211,共5页闫兆伟 朱海涛 董琼珠 周闯 张晓飞 任宁 叶青海 钦伦秀 
目的通过检测肝癌和癌旁组织中microRNA(miRNA)合成相关基因的mRNA表达,分析其与肝癌恶性行为的关系。方法运用实时荧光定量聚合酶链反应(RT-PCR)技术检测肝癌组织及其配对癌旁组织中miRNA生物合成相关基因的mRNA表达水平,比较分析其表...
关键词:肝细胞癌 MICRORNA DROSHA DGCR8 EXPORTIN 5 DICER AGO2 GEMIN3 GEMIN4 DBR1 ADAR 
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