National Institutes of Health,National Heart Lung Blood Institute(K99 HL155792,R00HL155792 to HM);Roswell Park Alliance(HM),a gift from Brendan and Elise McCarthy(PLM),and R01 CA205246(ER);Cytometry services were provided by the Flow and Image Cytometry Shared Resource at the Roswell Park Comprehensive Cancer Center,which is supported in part by the NCI Cancer Center Support Grant NCI R50CA211108;NCI grant P30CA016056 involving the use of Roswell Park Comprehensive Cancer Center’s Genomic and Flow and Image Cytometry Shared Resources.Selinexor was provided by Karyopharm,Newton,MA.
Myeloid-derived suppressor cells(MDSCs)are a main driver of immunosuppression in tumors.Understanding the mechanisms that determine the development and immunosuppressive function of these cells could provide new thera...
supported by the National Key Research and Development Program(2020YFA0907600);the Laboratory of Lingnan Modern Agriculture Project(NZ2021004);the Natural Science Foundation of Guangdong Province(2020A1515010157);the Science and Technology Program of Guangzhou(202102080499)。
The transport of proteins to and from the nucleus is necessary for many cellular processes and is one of the ways plants respond to developmental signals and environmental stresses.Nucleocytoplasmic trafficking of pro...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB27040203);supported by Chinese Academy of Sciences;supported by the National Natural Science Foundation of China(31570250)
In eukaryotic cells,transport of macromolecules across the nuclear envelope is an essential process that ensures rapid exchange of cellular components,including protein and RNA molecules.Chromatin regulators involved ...
Dear Editor,Targeting PI3K is a promising approach for cancer therapy,and the PI3Kα-selective inhibitor alpelisib has been approved for breast cancer treatment.1,2,3 However,the development of acquired resistance pos...
Alterations of drug efficacy by the circadian clock are a concern when assessing drug therapies. Circadian rhythms persist in some cancer cells and are repressed in others. A better understanding of circadian activiti...