国家自然科学基金(31321091)

作品数：5被引量：38H指数：2
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Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation
《Cell Research》2017年第2期253-273,共21页Shu-Xin Zhang Li-Hui Duan Shun-Ji He Gui-Feng Zhuang Xiang Yu 
We thank Professors Volker Haucke, Marc Kirschner, Alexander Sorisky and Jane Y Wu for constructs. We thank Yuan Lu and Zong-Fang Wan for excellent technical assistance. We thank Dr Qian Hu and ION Optical Imaging Core Facility for confocal microscopy and data analysis support, and Dr Min Jiang and IOBS-Nikon Biological Imaging Center for use of the N-SIM microscope. We are grateful to Drs Xueliang Zhu and Xiumin Yan, colleagues at ION, and members of the Yu laboratory for suggestions and comments. This work was supported by the National Natural Science Foundation of China （31321091 and 31530030）, the Strategic Priority Research Program of the Chinese Academy of Sciences （XDB02010000） and the Science and Technology Commission of Shanghai Municipality （16XD 1404800）.
Neurite initiation is critical for neuronal morphogenesis and early neural circuit development. Recent studies showed that local actin aggregation underneath the cell membrane determined the site of neurite initiation...
关键词：PI（3 4）P2 actin aggregation NEURITOGENESIS SHIP2 PI3K C2α dendritogenesis N-WASP 
Actin Aggregations Mark the Sites of Neurite Initiation被引量：2
《Neuroscience Bulletin》2016年第1期1-15,共15页Shu-Xin Zhang Li-Hui Duan Hong Qian Xiang Yu 
the ION Optical Imaging Core Facility for technical support;the IOBS-Nikon Biological Imaging Center for use of the N-SIM microscope;supported by grants from the National Natural Science Foundation of China(31125015 and31321091)
A salient feature of neurons is their intrinsic ability to grow and extend neurites, even in the absence of external cues. Compared to the later stages of neuronal development, such as neuronal polarization and dendri...
关键词：Neurite initiation NEURITOGENESIS Actinaggregations - Actin - Microtubules 
Neuroinflammation in Parkinson’s disease and its potential as therapeutic target被引量：34
《Translational Neurodegeneration》2015年第1期151-159,共9页Qinqin Wang Yingjun Liu Jiawei Zhou 
by grants from the National Key Basic Research Program of China(2011CB504102);Natural Science Foundation of China(31430036,31123002,31321091).
Parkinson’s disease(PD),the second most common age-associated neurodegenerative disorder,is characterized by the loss of dopaminergic(DA)neurons and the presence ofα-synuclein-containing aggregates in the substantia...
关键词：Parkinson’s disease NEURODEGENERATION Glial cells NEUROINFLAMMATION 
Non-apoptotic role of caspase-3 in synapse ref inement被引量：2
《Neuroscience Bulletin》2014年第4期667-670,共4页Jin-Yuan Wang Zhen-Ge Luo 
supported by grants from the National Natural Science Foundation (31330032,31321091,and 61327902);he National Basic Research Development Program of China (2014CB910203)
Caspases, a family of cysteine proteases, mediate programmed cell death during early neural development and neurodegeneration, as well as following neurotoxic insults. Notably, accumulating lines of evidence have show...
关键词：CASPASES neuronal plasticity synaptic refinement 
Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse
《Neuroscience Bulletin》2014年第3期425-432,共8页Yan Hu Sen Li Hua Jiang Ming-Tao Li Jia-Wei Zhou 
supported by grants from the Chinese Academy of Sciences;the National Basic Research Development Program of China (2011CB504102);the National Natural Science Foundation of China (31123002 and 31321091)
Postmitotic neurons in the neocortex migrate to appropriate positions and form layered structures of nascent cortex during brain development. The migration of these neurons requires precise control and coordination of...
关键词：neuron migration Eph receptor A4 ephrin-B2 cerebral cortex development 
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