国家自然科学基金(31210103916)

作品数：5被引量：7H指数：2
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Immunosuppression Induced by Brain-Specific HDAC6 Knockdown Improves Aging Performance in Drosophila melanogaster被引量：1
《Phenomics》2022年第3期194-200,共7页Yingying Zhao Hongwen Xuan Chao Shen Peiyi Liu Jing-Dong J.Han Wei Yu 
This work was supported by grants from the National Natural Science Foundation of China(31771545,92049301,31821002,91329302,and 31210103916);China Ministry of Science and Technology(2015CB964803,2016YFE0108700,and 2016YFA0500600),and Max Planck fellowship to J.D.J.H.
HDAC6 is involved in several biological processes related to aging-associated diseases.However,it was unknown whether HDAC6 could directly regulate lifespan and healthspan.We found that HDAC6 knockdown induced transcr...
关键词：HDAC6 AGING DROSOPHILA INFLAMMATION Innate immunity Motor neuron 
Characterization of functional transposable element enhancers in acute myeloid leukemia
《Science China(Life Sciences)》2020年第5期675-687,共13页Yingying Zeng Yaqiang Cao Rivka Sukenik Halevy Picard Nguyen Denghui Liu Xiaoli Zhang Nadav Ahituv Jing-Dong JHan 
supported by grants from the National Natural Science Foundation of China(91749205,91329302,and 31210103916);Ministry of Science and Technology of China(2015CB964803 and 2016YFE0108700);a Max Planck fellowship to J.D.J.H.supported by the National Human Genome Research Institute(NHGRI)and the National Cancer Institute(1R01CA197139);NHGRI(1UM1HG009408);the National Health Lung and Blood Institute(1R01HL138424)。
Transposable elements(TEs)have been shown to have important gene regulatory functions and their alteration could lead to disease phenotypes.Acute myeloid leukemia(AML)develops as a consequence of a series of genetic c...
关键词：transposable element ENHANCER PROMOTER MIR acute myeloid leukemia 
衰老过程中的表观遗传调控
《生命科学》2017年第10期1052-1065,共14页豆晓阳 玄鸿文 穆永林 韩敬东 
国家自然科学基金项目(31210103916,91329302,91519330);国家重点基础研究发展计划(“973”项目)(2015CB964803,2016YFE0108700)
生物体衰老表现为性成熟后生理功能的逐渐衰退,最终引发疾病和死亡。表观遗传调控的紊乱作为衰老的一个重要特征,暗示可以通过干预表观遗传调控来延缓衰老并治疗衰老相关疾病。现就衰老过程中的表观遗传调控的最新进展作一综述。
关键词：衰老 DNA甲基化 组蛋白修饰 染色质重塑 非编码RNA 
Structure-based protein-protein interaction networks and drug design被引量：3
《Frontiers of Electrical and Electronic Engineering in China》2013年第3期183-191,共9页Hammad Naveed Jingdong J. Han 
This work was funded by grants from the National Natural Science Foundation of China （NSFC） （Grant No. 31210103916 and 91019019）, Chinese Ministry of Science and Technology （Grant No. 2011CB504206） and Chinese Academy of Sciences （CAS） （Grant Nos. KSCX2-EW-R-02 and KSCX2-EW-J-15） and stem cell leading project XDA01010303 to J.D.J.H.H.N. was supported by the Chinese Academy of Sciences Fellow- ship for Young International Scientist [Grant No. 2012Y1SB0006] and the National Natural Science Foundation of China [Grant No. 31250110524]. The authors thank Dr. Jerome Boyd-Kirkup for extensive editing and Hamna Anwar for proofreading the manu- script.
Proteins carry out their functions by interacting with other proteins and small molecules, forming a complex interaction network. In this review, we briefly introduce classical graph theory based protein-protein inter...
关键词：protein-protein interaction NETWORK STRUCTURE-BASED drug design drug reposition 
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