国家自然科学基金(30370354)

作品数:6被引量:4H指数:1
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相关作者:卢正鼎陆枫肖奕刘怀兰周权雄更多>>
相关机构:华中科技大学更多>>
相关期刊:《Science Bulletin》《小型微型计算机系统》《科学通报》《Genomics, Proteomics & Bioinformatics》更多>>
相关主题:GPCRSUPPORT_VECTOR_MACHINESWEB视图对象视图模型构建更多>>
相关领域:生物学自动化与计算机技术医药卫生更多>>
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ModuleNet:An R package on regulatory network building
《Chinese Science Bulletin》2010年第30期3430-3435,共6页ZHOU Dao HE Dong LUO QingMing ZHOU YanHong 
supported by the National Natural Science Foundation of China (90608020 and 30370354);the National Platform Project of China (2005DKA64001);the Ministry of Education of China (NCET-060651)
Many researchers have used microarray gene expression data to investigate gene regulatory networks in specific life stages. In these analyses,Bayesian network was widely applied to regulatory network building from exp...
关键词:网络建设 监管 贝叶斯网络模型 基因表达数据 基因表达谱 转录因子 封装 基因调控网络 
基于Web视图模型构建生物信息二级数据库被引量:2
《小型微型计算机系统》2006年第3期492-496,共5页陆枫 卢正鼎 肖奕 
国家"八六三"高技术研究发展计划基金项目(2001AA231071)资助;国家自然科学基金项目(30370354)资助.
提出采用带根连通有向图来描述生物信息二级数据库的Web视图模型,以结合生物信息背景知识设计特定的生物信息Web视图及其间的相关关系.通过常量、静态和动态三类视图构成的Web视图模型解决了生物信息计算与数据资源共享的统一概念抽象....
关键词:生物信息二级数据库 WEB视图 带根连通有向图 对象视图 
A Contact Energy Function Considering Residue Hydrophobic Environment and Its Application in Protein Fold Recognition被引量:1
《Genomics, Proteomics & Bioinformatics》2005年第4期218-224,共7页Mo-Jie Duan Yan-Hong Zhou 
supported by the National Natural Science Foundation of China(No.90203011 and 30370354);the Ministry of Education of China(No.505010 and CG2003-GA002)
The three-dimensional (3D) structure prediction of proteins :is an important task in bioinformatics. Finding energy functions that can better represent residue-residue and residue-solvent interactions is a crucial ...
关键词:protein structure prediction fold recognition contact  energy hydrophobic environment 
Prediction and Classification of Human G-protein Coupled Receptors Based on Support Vector Machines被引量:1
《Genomics, Proteomics & Bioinformatics》2005年第4期242-246,共5页Yun-Fei Wang Huan Chen Yan-Hong Zhou 
supported by the National Natural Science Foundation of China(No.90203011 and 30370354);the Ministry of Education of China(No.505010 and CG2003-GA002).
A computational system for the prediction and classification of human G-protein coupled receptors (GPCRs) has been developed based on the support vector machine (SVM) method and protein sequence information. The f...
关键词:GPCR PREDICTION CLASSIFICATION SVM 
Predicting the Coupling Specificity of G-protein Coupled Receptors to G-proteins by Support Vector Machines
《Genomics, Proteomics & Bioinformatics》2005年第4期247-251,共5页Cui-Ping Guan Zhen-Ran Jiang Yan-Hong Zhou 
supported by the National Natural Science Foundation of China(No.90203011 and 30370354);the Ministry of Education of China(No.505010 and CG2003-GA002).
G-protein coupled receptors (GPCRs) represent one of the most important classes of drug targets for pharmaceutical industry and play important roles in cellular signal transduction. Predicting the coupling specifici...
关键词:GPCR G-PROTEIN SVM coupling specificity 
基于密码子使用特征预测家族性扩张型心肌病的疾病基因
《科学通报》2005年第20期2235-2239,共5页周艳红 周权雄 刘怀兰 万宏辉 
国家自然科学基会(批准号:90203011,30370354);湖北省自然科学基金(批准号:2002AC014)资助项目.
家族性扩张型心肌病(FDC)是一种以常染色体显性遗传为主的单基因病,迄今已定位了15个常染色体显性遗传FDC的疾病基因区间,但只确定了其中8个定位区间的致病基因,另外7个定位区间中的FDC疾病基因仍有待发现.本文对已知的FDC疾病基因序列...
关键词:家族性扩张型心肌病 FDC 常染色体 显性遗传 密码子 
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