国家自然科学基金(30370506)

作品数：7被引量：15H指数：3
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相关作者：顾振纶秦正红林芳陈志欣刘春风更多>>
相关机构：苏州大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Acta Biochimica et Biophysica Sinica》《中华医学遗传学杂志》更多>>
相关主题：HUNTINGTIN亨廷顿舞蹈病CASPASEHTT不自主运动更多>>
相关领域：医药卫生生物学更多>>
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Huntingtin Cleavage Induced by Thrombin In Vitro
《Acta Biochimica et Biophysica Sinica》2007年第1期15-18,共4页Fang LIN Junchao WU Yan WANG and Zhenghong QIN Department of Pharmacology,Laboratory of Aging and Nervous Diseases,Soochow University School of Medicine,Suzhou 215123,China 
This work was supported by grants from the National Natural Science Foundation of Chilla(No. 30370506);the China Postdoctoral Science Foundation;the Specialized Research Fund for the Doctoral Program of Higher Education(No.20050285017)
Huntingtin （Htt） mutation causes Huntington＇s disease. Sequence analysis of Htt revealed a possible thrombin cleavage site in the N-terminal region of Htt. In order to investigate if thrombin can cleave Htt, we exp...
关键词：THROMBIN huntingtin （Htt） CLEAVAGE HIRUDIN 
Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies被引量：2
《Acta Pharmacologica Sinica》2006年第10期1287-1302,共16页Lin-hui WANG Zheng-hong QIN 
Project supported by the National Natural Science Foundation of China(No 30370506);by the Specialized Research Fund for the Doctoral Program of Higher Education(No 20050285017).
Huntington＇s disease （HD） is an autosomal dominant neurodegenerative disorder, which is caused by an abnormal expansion of Cytosine Adenine Guanine （CAG） trinucleotide repeat in the gene making huntingtin （Htt）...
关键词：Huntington＇s disease HUNTINGTIN NEURODEGENERATION animal models 
Quality Control System of the Endoplasmic Reticulum and Related Diseases被引量：4
《Acta Biochimica et Biophysica Sinica》2006年第4期219-226,共8页Jun-Chao WU Zhong-Qin LIANG Zheng-Hong QIN 
This work was supported by the grants from the National Natural Science Foundation of China (No.30370506);the Doctoral Program of Higher Education of China (No.20050285017)
The quality control （QC） system of the endoplasmic reticulum （ER） is an important monitoring mechanism in the protein maturation process, which ensures export of properly folded proteins from the ER. Incorrectly o...
关键词：protein folding quality control calnexin/calreticulin cycle endoplasmic reticulum-associated degradation protein misfolding disease 
亨廷顿舞蹈病一家系四例被引量：4
《中华医学遗传学杂志》2006年第4期486-486,共1页林芳 陈志欣 刘春风 顾振纶 秦正红 
江苏省博士后基金;国家自然科学基金(30370506)
关键词：亨廷顿舞蹈病 家系 注意力不集中 不自主运动 运动不协调 无感觉障碍 精细动作 情绪不稳 反应迟钝 先证者 
Caspase和calpain在神经元凋亡和亨廷顿舞蹈病发病机制中的作用
《神经科学通报》2005年第3期224-229,共6页王燕 顾振纶 秦正红 
by the National Natural Science Foundation of China(No 30370506).
亨廷顿舞蹈病(Huntington disease,HD)是由亨廷顿蛋白(huntingtin,Htt)N端多聚谷氨酰胺序列延长引起的神经退行性疾病。一组半胱氨酸蛋白酶(caspase)和钙蛋白酶(calpain)可剪切突变Htt,产生毒性较大的N端Htt片段。近年的研究表明,该剪...
关键词：CASPASE CALPAIN 神经元凋亡 亨廷顿舞蹈病 HD HTT 神经退行性疾病 
Development of novel therapies for Huntington's disease:hope and challenge被引量：3
《Acta Pharmacologica Sinica》2005年第2期129-142,共14页Zheng-hongQIN JinWANG Zhen-lunGU 
Supported by the National Natural Science Foundation of China(№ 30370506).
Huntington's disease(HD)is an autosomal dominant neurological disease.It is a fatal neurological disorder affecting 5-10 out of 10000 people.While there are intensive research efforts focusing on uncovering molecular ...
关键词：Huntington disease HUNTINGTIN AGGREGATES CASPASES nerve growth factors cell transplantation coenzyme Q10 
Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum被引量：2
《Acta Pharmacologica Sinica》2005年第2期150-154,共5页YiCAO Zhen-lunGU FangLIN RongHAN Zheng-hongQIN 
Project supported by the National Natural Science Foundation of China(№ 30370506).
Aim:To study the effects of the caspase-1 inhibitor Ac-YVAD-CHO on quinolinic acid(QA)-induced apoptosis.Methods:Rats were pre-treated with intrastriatal infusion of Ac-YVAD-CHO(2-8μg)before intrastriatal injection o...
关键词：caspase 1 Ac-YVAD-CHO Huntington disease protein p53 NF-kappaB inhibitor alpha APOPTOSIS NF-KAPPAB 
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