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国家自然科学基金(81130024): 作品数：26被引量：123H指数：7; 导出分析报告; 相关作者：李涛邓伟李名立李寅飞刘祥更多>>; 相关机构：四川大学华西医院四川大学华西医科大学广州市脑科医院更多>>; 相关期刊：《临床精神医学杂志》《精神医学杂志》《中华精神科杂志》《神经疾病与精神卫生》更多>>; 相关主题：精神分裂症非缺陷型缺陷型首次发病SCHIZOPHRENIA更多>>; 相关领域：医药卫生生物学理学更多>>

首次发病未治疗精神分裂症患者大脑皮质复杂度改变被引量：11: 《中华精神科杂志》2020年第1期11-15,共5页魏巍邓伟周燚彭祖贵何韬吕秋玥李涛; 科技部国家重点基础研究发展计划(2016YFC0904300);国家自然科学基金项目(81630030,81130024,81461168029);四川大学华西医院卓越学科发展135计划(ZY2016203,ZY2016103)。; 目的探讨首次发病未治疗精神分裂症患者大脑皮质复杂度的异常特征及其与临床症状的相关性。方法使用Philip 3.0 T磁共振成像系统采集77例首次发病未治疗精神分裂症患者(患者组)及84名健康对照者(对照组)的高分辨率3D脑结构图像,采用基于...; 关键词：精神分裂症磁共振成像神经发育假说皮质复杂度分型维度

GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia被引量：9: 《Neuroscience Bulletin》2020年第2期97-109,共13页Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li; supported by the National Natural Science Foundation of China(81630030,81130024,and 81528008);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme(81461168029);the National Basic Research Development Program of China(2016YFC0904300);the Science and Technology Project of the Health Planning Committee of Sichuan(19PJ090);the National Natural Science Foundation of China for Distinguished Young Scholars(81501159).; The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients wi...; 关键词：ERBB4 SCHIZOPHRENIA MRI Gene pathway Mouse

White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging被引量：10: 《Neuroscience Bulletin》2019年第5期867-876,共10页Sugai Liang Qiang Wang Xiangzhen Kong Wei Deng Xiao Yang Xiaojing Li Zhong Zhang Jian Zhang Chengcheng Zhang Xin-min Li Xiaohong Ma Junming Shao Andrew J. Greenshaw Tao Li; supported by the National Natural Science Foundation of China (81630030, 81130024, 81801326, and 81571320);the National Natural Science Foundation of China/ Research Grants Council of Hong Kong Joint Research Scheme (81461168029);the National Basic Research Development Program of China (2016YFC0904300);the 1.3.5 Project for Disciplines of Excellence, West China Hospital of Sichuan University;the National High-Technology Research and Development Project (863 Project) of China (2015AA020513);a Scientific Project of Sichuan Science and Technology Department, China (2015JY0173); Identifying data-driven biotypes of major depressive disorder(MDD) has promise for the clarification of diagnostic heterogeneity. However, few studies have focused on white-matter abnormalities for MDD subtyping. This...; 关键词：Major DEPRESSIVE DISORDER Hierarchal clustering Diffusion TENSOR imaging BIOTYPE HETEROGENEITY

Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia被引量：5: 《Neuroscience Bulletin》2019年第4期688-696,共9页Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li; supported by the National Basic Research Development Program of China (2016YFC0904300);National Natural Science Foundation of China (81630030, 81130024 and 81528008);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (81461168029);the ‘‘135’’ Project for Disciplines of Excellence, West China Hospital of Sichuan University, China (ZY2016103 and ZY2016203); Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characte...; 关键词：SCHIZOPHRENIA CORTICAL thickness AGE-RELATED

Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance被引量：3: 《Science China(Life Sciences)》2019年第4期535-543,共9页Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium; supported by the National Natural Science Foundation of China Key Project(91332205,81130024,81630030to T.L.);National Natural Science Foundation of China(8157051859 to W.D.et al.);National Key Technology R&D Program of the Ministry of Science and Technology of China(2016YFC0904300 to T.L.);National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme(8141101084 to T.L.);Sichuan Science&Technology Department(2015JY0173 to Q.W.);1.3.5 Project for disciplines of excellence,West China Hospital of Sichuan University(ZY2016103,ZY2016203 to T.L.); Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) ...; 关键词：MC4R ANTIPSYCHOTICS METABOLIC DISTURBANCE

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features被引量：7: 《Neuroscience Bulletin》2018年第2期312-320,共9页Sugai Liang Roberto Vega Xiangzhen Kong Wei Deng Qiang Wang Xiaohong Ma Mingli Li Xun Hu Andrew J.Greenshaw Russell Greiner Tao Li; funded by National Nature Science Foundation of China Key Projects(81130024,91332205,and 81630030);the National Key Technology R&D Program of the Ministry of Science and Technology of China(2016YFC0904300);the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme(8141101084);the Natural Science Foundation of China(8157051859);the Sichuan Science&Technology Department(2015JY0173);the Canadian Institutes of Health Research,Alberta Innovates:Centre for Machine Learning;the Canadian Depression Research&Intervention Network; Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder(MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitiv...; 关键词：SCHIZOPHRENIA Major depressive disorder NEUROCOGNITION Neurocognitive graph Graphical LASSO

首发精神分裂症患者认知功能和临床特征与脑源性生长因子基因Va166Met多态性的相关性被引量：15: 《中华医学遗传学杂志》2017年第4期592-596,共5页张程程谷晓楚王强李名立邓伟郭万军赵连生马小红李涛; 国家自然科学基金（81130024,30530300,91332205）;科技部十二五支撑计划（2012BA101806）; 目的探讨首发精神分裂症患者的认知功能损害和临床特征与脑源性生长因子（brain-derivedneurotrophicfactor，BDNF）基因Va166Met多态性的相关性。方法采用TaqMan荧光探针技术对87例首发精神分裂症患者和76名对照者BDNF基因的Va166Met（...; 关键词：精神分裂症脑源性生长因子认知功能

基于通路分析的全基因组甲基化水平与视觉记忆的相关性研究: 《中华医学遗传学杂志》2015年第5期625-628,共4页谷晓楚倪培艳向波赵连生韦锦学王英成马小红李涛; 国家自然科学基金（81130024,30530300,30125014）;科技部十二五支撑计划（2012BA101B06）;教育部博士点基金（20110181110014,20130181120032）;苏州市科技计划项目（SY$201370）; 目的通过对全基因组启动子甲基化程度与视觉记忆强相关的基因进行生物信息学分析，寻找与记忆功能相关的基因所在信号通路。方法对9名正常人外周血单核细胞DNA样本进行甲基化DNA免疫共沉淀芯片分析。将基因的启动子区域甲基化水平与即...; 关键词：基因组甲基化视觉记忆相关性研究

Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese: 《Neuroscience Bulletin》2015年第3期368-370,共3页Cheng-Cheng Zhang H ong-Yan Ren Ming-LiLi Qiang Wang Wei Deng Wan-Jun Guo Wei Lei Bo Xiang Lian-Sheng Zhao Xiao-Hong Ma Yong-Gang Yao Tao Li; supported by the National Natural Science Foundation of China (81130024);the National Key Technology R & D Program of the Ministry of Science and Technology of China during the 12th Five-Year Plan (2012BAI01B06); Dear Editor,A few studies have focused on exploring APOE gene- related effects on cognitive functions and brain activities in healthy populations. Bondi et aL found that ε4 carriers perform significantly worse on the...; 关键词：Apolipoprotein E gene polymorphisms associated with processing speed and executive functions in healthy Han Chinese GENE

首发精神分裂症与双相障碍Ⅰ型患者失匹配负波的对照研究被引量：3: 《精神医学杂志》2015年第1期1-5,共5页李喆邓伟王强李名立李寅飞刘祥郑重李涛; 国家自然科学基金项目(编号:81130024);科技部"十二五"支撑计划项目(编号:2012BAI01B06);教育部博士点基金项目(编号:20110181110014);四川省卫生厅课题(编号:130039); 目的探讨首发精神分裂症患者与伴精神症状史的双相I型患者的失匹配负波(MMN)及其与临床特征的相关性。方法比较45例首发精神分裂症患者(精神分裂症组),55例伴精神症状史的双相I型患者(双相障碍组)以及50例正常对照(对照组)的MMN;阳性和...; 关键词：精神分裂症双相障碍失匹配负波

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