云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(20175026)

国家自然科学基金(20175026): 作品数：13被引量：19H指数：3; 导出分析报告; 相关作者：赵玉芬钟儒刚赵丽娇陈晓岚廖新成更多>>; 相关机构：郑州大学清华大学北京工业大学教育部更多>>; 相关期刊：《有机化学》《Science Bulletin》《化学学报》《Chinese Journal of Chemistry》更多>>; 相关主题：N-AMINO_ACIDESIESI-MSPHOSPHORYLATION更多>>; 相关领域：理学生物学医药卫生更多>>

Synthesis of Novel Phosphorylated Daidzein Derivatives and ESI Investigation on Their Non-Covalent Complexes with Lysozyme被引量：6: 《Chinese Journal of Chemistry》2007年第7期1008-1013,共6页陈晓岚石晓娜屈凌波袁金伟卢建莎赵玉芬; Project supported by the National Natural Science Foundation of China （Nos. 20132020 and 20175026） and Henan Academic Foundation of Science and Technology.; Daidzein （7,4＇-dihydroxyisoflavone） was phosphorylated by a modified Atherton-Todd reaction. The structures of the five target product, were determined by X-ray, IR, NMR and ESI-MS. Electrospray ionization results ...; 关键词：DAIDZEIN PHOSPHORYLATION ESI-MS non-covalent complex

N-磷酰化氨基酸生成五配位磷中间体过程中氨基酸侧链立体化学效应的理论研究: 《化学学报》2006年第9期959-962,共4页赵丽娇钟儒刚甄岩赵玉芬; 国家自然科学基金(No.20175026);北京市人才强教计划资助项目; 用密度泛函(DFT)方法在B3LYP/6-311G(d,p)水平上对N-磷酰化氨基酸生成五配位磷酸羧酸混酐(IMCPA)反应中手性氨基酸残基侧链的立体化学效应进行了研究.模拟了氨基酸残基上羧基氧原子从磷酰基的不同侧面进攻磷原子从而形成不同构型五配位...; 关键词：N-磷酰化氨基酸生命起源立体化学效应 DFT

丝组二肽对DNA切割作用的QM-MM研究被引量：4: 《化学学报》2004年第24期2444-2446,共3页钟儒刚赵丽娇赵玉芬; 国家自然科学基金 (No.2 0 1 750 2 6)资助项目; 运用QM MM方法对丝组二肽切割DNA作用的机理进行了研究 .通过计算得到了丝组二肽与DNA形成多氢键作用的有效分子识别模型及相关分子结构参数 ,从理论上解释了丝组二肽与DNA通过形成五配位磷中间体而使磷酸二酯键发生水解 ,从而使得DNA...; 关键词：MM DNA 二肽生水酯键作用研究上解配位分子识别

Elucidation of O-Phosphoryl and N-Phosphoryl Amino Acids by Electrospray Ionization Tandem Mass Spectrometry: 《Chinese Journal of Chemistry》2004年第8期870-873,共4页张建臣曹书霞徐军廖新成赵玉芬; Project supported by the National Natural Science Foundation of China (No. 20175026).; Mass spectroscopic characteristics of phosphoryl amino acids were studied in detail by positive and negative electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). Be...; 关键词：N-phosphoryl amino acid O-phosphoryl amino acid electrospray ionization tandem mass spec- trometry

Novel Rearrangement of Small Peptides in Electrospray Ionization Tandem Mass Spectrometry被引量：1: 《Chinese Journal of Chemistry》2004年第5期477-481,共5页陈益王津刘晓红孙命陈晶江洋赵玉芬; Project supported by the Chinese National Natural Science Foundation (No. 20175026); the Ministry of Science and Technology; the visiting scholar fund of the Chinese Education Ministry; and Tsinghua University.; Electrospray ionization mass spectrometry (ESI-MS) is a powerful method for sequencing peptides. A novel fragmentation pattern with the loss of a neutral fragment of 45 Da was observed with the dipeptides, tripeptides...; 关键词：REARRANGEMENT small peptides electrospray ionization tandem mass spectrometry

氨基酸复合物的电喷雾质谱研究被引量：4: 《分析测试学报》2004年第3期64-66,共3页曹书霞杨晓丽陈晓岚廖新成赵玉芬; 国家自然科学基金资助项目 (20175026); 采用电喷雾 -离子阱质谱技术 ,对水溶液中氨基酸的自身聚合以及和碱金属离子形成的复合物进行了研究。发现不同的氨基酸和不同的碱金属离子具有不同的聚合特点。; 关键词：电喷雾-质谱(ESI—MS) 氨基酸复合物液相色谱-质谱

2',3'-双脱氢-2',3'双脱氧胸苷5'-亚磷酸苄酯的ESI-MS^n中的一种新颖的重排反应: 《分析测试学报》2004年第z1期122-123,共2页陈益赵玉芬; 国家自然科学基金资助项目(20175026); 　　爱滋病(AIDS)是一种严重威胁人类健康的传染性疾病.研究和开发新的、高疗效的抗AIDS的药物已成了生物学家、化学家和药物学家的主要的研究方向之一.2′,3′-双脱氢-2′,3′-双脱氧胸苷(d4T)是HIV逆转录酶抑制剂[1,2],它们是美国FDA...; 关键词：2’ 3’ -didehydro-2’ 3’ -dideoxythymidin-5’ -yl H-phosphonates Electrospray ionization multistage mass spectra Anti-HIV prodrug REARRANGEMENT

Synthesis and Chiral Separation of Dinucleotide(TpAZT) Phosphoramidates: 《Chinese Chemical Letters》2003年第8期779-782,共4页ChangXueLIN HuaFU GuangZhongTU YuFenZHAO; The authors would like to thank the financial supports from the National Natural Science Foundation of China(No.29902003,20132020 and 20175026),the Ministry of Science and Technology,the Chinese Ministry of Education and Tsinghua University.; Dinucleotide (TpAZT) phosphoramidates were synthesized by Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Sp) were separated by crystallization, and the resul...; 关键词：Dinucleotide phosphoramidate chiral auxiliary chiral separation.

电喷雾质谱动力学方法测定磷酰化丙丙二肽的气相质子亲和能被引量：2: 《高等学校化学学报》2003年第3期459-461,共3页陈晶陈益江洋赵玉芬; 国家自然科学重点基金 (批准号 :2 0 175 0 2 6)资助; In this work, the change of gas-phase proton affinity of alkyl-alanine through the phosphorylation reaction was studied by the electrospray ionization mass spectrometry with kinetic method. It was proved that the phos...; 关键词：电喷雾质谱动力学方法测定磷酰化丙丙二肽气相质子亲和能

Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry: 《Chinese Chemical Letters》2003年第2期195-196,共2页Hai LIU Jing CHEN 等; the National Natural Science Foundation of China (No. 20175026); the Ministry of Science and Technology of China; the Education Ministry of China and Tsinghua University for financial support.; With introduction of a diisopropyloxy phosphoryl group into the N terminal of amino acids, it was found that proton affinity (PA) of amino acid was enhanced in mass spectrometry. Density functional theory calculation...; 关键词：Proton affinity diisopropyloxy phosphoryl group amino acid mass spectrometry.

国家自然科学基金(20175026)