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北京市自然科学基金: 作品数：52600被引量：329876H指数：112; 导出分析报告; 相关作者：冯仲科李林王有年吴斌王治国更多>>; 相关机构：北京工业大学首都医科大学北京大学北京交通大学更多>>; 相关期刊：更多>>; 相关主题：小鼠数值模拟影响因素儿童网络更多>>; 相关领域：医药卫生自动化与计算机技术理学农业科学更多>>

1%富血小板血浆联合骨髓间充质干细胞促进周围神经损伤的修复: 《中国组织工程研究》2024年第7期985-992,共8页冯睿钦韩娜张蒙谷馨怡张丰识; 北京市自然科学基金(7222198),项目负责人:韩娜。; 背景:富血小板血浆已被证明能够增强间充质干细胞活性并具有促血管再生能力。细胞外囊泡是间充质干细胞发挥作用的关键介质之一,但目前还不清楚富血小板血浆是否能影响细胞外囊泡的功能。目的:探索富血小板血浆对骨髓间充质干细胞分泌...; 关键词：富血小板血浆间充质干细胞细胞外囊泡周围神经损伤施万细胞重编程神经导管间充质干细胞移植坐骨神经损伤

脐带间充质干细胞治疗多囊卵巢综合征的作用及机制被引量：1: 《中国组织工程研究》2024年第7期1015-1020,共6页刘麒薇张俊辉杨袁王金娟; 北京市自然科学基金资助项目(7214228),项目负责人:刘麒薇。; 背景:目前对多囊卵巢综合征的治疗大多是超指征用药,对其治疗仍面临很大的挑战。研究证明人脐带间充质干细胞可修复卵巢功能,但鲜有研究报道其对多囊卵巢综合征的治疗作用。目的:观察人脐带间充质干细胞对多囊卵巢综合征的治疗作用,并...; 关键词：脐带间充质干细胞多囊卵巢综合征排卵障碍内分泌紊乱线粒体自噬

不同因素影响激素性股骨头坏死家兔模型成模效果的网状Meta分析被引量：1: 《中国组织工程研究》2024年第6期976-984,共9页胡智星李群杨超王潇潇方罗昌婷侯吴琼林娜陈卫衡刘春芳林雅; 国家自然科学基金重点项目(82030122),项目负责人:陈卫衡;国家自然科学基金面上项目(81973888),项目负责人:陈卫衡;北京市自然科学基金面上项目(7232304),项目负责人:刘春芳;中央级公益性科研院所基本科研业务费专项(ZXKT20013),项目负责人:刘春芳;中国中医科学院科技创新工程项目(C12021A03808),项目负责人:林娜。; 目的:激素性股骨头坏死家兔模型是最常用的股骨头坏死动物模型,其股骨头病理学改变与临床较为接近,但目前国内外报道的造模条件、方法和评价标准等均不统一,导致所建立动物模型的科学价值低、难于推广应用。此次研究旨在明确不同造模条...; 关键词：激素性股骨头坏死家兔动物模型造模方法影响因素亚组分析网状Meta分析循证医学

Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke被引量：6: 《Neural Regeneration Research》2024年第2期409-415,共7页Hongmei Duan Shulun Li Peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li; supported by the National Natural Science Foundation of China,Nos.81941011(to XL),31771053(to HD),31730030(to XL),31971279(to ZY),31900749(to PH),31650001(to XL),31320103903(to XL),31670988(to ZY);the Natural Science Foundation of Beijing,Nos.7222004(to HD);a grant from Ministry of Science and Technology of China,Nos.2017YFC1104002(to ZY),2017YFC1104001(to XL);a grant from Beihang University,No.JKF-YG-22-B001(to FH)。; Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactiv...; 关键词：adult endogenous neurogenesis ANGIOGENESIS basic fibroblast growth factor-chitosan gel CHITOSAN functional recovery ischemic stroke neural stem cell newborn neuron

Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment被引量：2: 《Neural Regeneration Research》2024年第2期440-446,共7页Sumei Liu Baoguo Liu Qian Li Tianqi Zheng Bochao Liu Mo Li Zhiguo Chen; supported by the Stem Cell and Translation National Key Project,No.2016YFA0101403(to ZC);the National Natural Science Foundation of China,Nos.82171250 and 81973351(to ZC);the Natural Science Foundation of Beijing,No.5142005(to ZC);Beijing Talents Foundation,No.2017000021223TD03(to ZC);Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan,No.CIT&TCD20180333(to ZC);Beijing Municipal Health Commission Fund,No.PXM2020_026283_000005(to ZC);Beijing One Hundred,Thousand,and Ten Thousand Talents Fund,No.2018A03(to ZC);the Royal Society-Newton Advanced Fellowship,No.NA150482(to ZC);the National Natural Science Foundation of China for Young Scientists,No.31900740(to SL)。; Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells a...; 关键词：biomaterial FIBRINOGEN functional recovery induced neural stem cell transplantation MICROENVIRONMENT MICROGLIA spinal cord injury THROMBIN

Advantages of nanocarriers for basic research in the field of traumatic brain injury被引量：2: 《Neural Regeneration Research》2024年第2期237-245,共9页Xingshuang Song Yizhi Zhang Ziyan Tang Lina Du; supported by the Natural Science Foundation of Beijing,No.L222126(to LD)。; A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researche...; 关键词：blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell NANOCARRIERS nanoparticles neural restoration traumatic brain injury

Advances in probing single biomolecules: From DNA bases to glycans: 《Interdisciplinary Materials》2023年第4期511-528,共18页Baofei Hou Teng Zhang Huixia Yang Xu Han Liwei Liu Linfei Li Cesare Grazioli Xu Wu Nan Jiang Yeliang Wang; support of the Beijing Natural Science Foundation(Nos.Z190006 and 4192054);National Key Research and Development Program of China(Nos.2019YFA0308000,2020YFA0308800,and 2021YFA1400100);National Natural Science Foundation of China(Nos.92163206,61971035,61725107,and 62271048);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB30000000).; Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level.Among the various imaging techniques availabl...; 关键词：atomic-scale probing biomolecules scanning probe microscopy structure VISUALIZATION

基于肖维勒准则与主元分析的有机朗肯循环神经网络建模方法被引量：5: 《大电机技术》2023年第6期70-76,共7页平旭杨富斌张红光邢程达杨海龙王焱; 国家自然科学基金(51906119);北京市自然科学基金(3222024);天津大学内燃机燃烧学国家重点实验室2020年开放课题(K2020-08)。; 随着人工神经网络技术的不断发展,有机朗肯循环(organic Rankine cycle,ORC)神经网络模型广泛应用于系统分析和优化领域。针对现有ORC神经网络模型计算量大、时间周期长和精度偏低的问题,本文提出了基于肖维勒准则与主元分析的ORC神经...; 关键词：有机朗肯循环人工神经网络建模肖维勒准则主元分析

Hierarchical predictive energy management strategy for fuel cell buses entering bus stops scenario: 《Green Energy and Intelligent Transportation》2023年第4期1-12,共12页Mei Yan Hongyang Xu Menglin Li Hongwen He Yunfei Bai; supported by the National Natural Science Foundation of China(Grand No.52202484);the Hebei Natural Science Foundation(Grand No.F2021203118);the Beijing Natural Science Foundation(Grand No.J210007);the Science and Technology Project of Hebei Education Department(Grand No.QN2022093).; This paper aims to answer how to use traffic information to design energy management strategies for fuel cell buses in a networked environment.For the buses entering the bus stops scenario,this paper proposes a hierar...; 关键词：Fuel cell bus Entering the bus stops scenario Predictive energy management strategy Traffic information Velocity planning SOC trajectory

Social Engineering Attack-Defense Strategies Based on Reinforcement Learning: 《Computer Systems Science & Engineering》2023年第11期2153-2170,共18页Rundong Yang Kangfeng Zheng Xiujuan Wang Bin Wu Chunhua Wu; funded by the Beijing Natural Science Foundation (4202002).; Social engineering attacks are considered one of the most hazardous cyberattacks in cybersecurity,as human vulnerabilities are often the weakest link in the entire network.Such vulnerabilities are becoming increasingl...; 关键词：Social engineering game theory reinforcement learning Q-LEARNING

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