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上海市自然科学基金: 作品数：21285被引量：103522H指数：63; 导出分析报告; 相关作者：王致杰陈新军杨海马王昕刘勤明更多>>; 相关机构：上海理工大学上海交通大学复旦大学同济大学更多>>; 相关期刊：更多>>; 相关主题：数值模拟英文遗传算法网络肿瘤更多>>; 相关领域：医药卫生理学自动化与计算机技术电子电信更多>>

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease被引量：1: 《Neural Regeneration Research》2024年第1期100-115,共16页Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao Gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang Jie Gao You Yin; supported by the National Natural Science Foundation of China,Nos.82072051 and 81771964(both to JG);the Natural Science Foundation of Shanghai Municipal Science and Technology Commission,No.22ZR147750(to YY);Science and Technology Support Projects in Biomedicine Field of Shanghai Science and Technology Commission,No.19441907500(to YY);Innovative Clinical Research Project of Changzheng Hospital,No.2020 YLCYJ-Y02(to YY);Characteristic Medical Service Project for the Army of Changzheng Hospital,No.2020 CZWJFW12(to YY)。; The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease progression.Therefo re,there is an urgent need for new effective drugs.The underlying pathogenic factors of Alzheim...; 关键词：Alzheimer's disease ANTI-INFLAMMATION blood-brain barrier drug delivery MICROGLIA NANOPARTICLES NEUROINFLAMMATION plant extracts

补骨脂-淫羊藿对类风湿关节炎抗炎机制的分子对接分析:动物实验验证被引量：2: 《中国组织工程研究》2024年第2期208-215,共8页冉磊韩海慧徐博王建业沈军肖涟波施杞; 上海市卫生健康委员会上海市临床重点专科建设项目(shslczdzk04801),项目负责人:肖涟波;上海市自然基金面上项目(22ZR1453100),项目负责人:肖涟波;上海市中医临床高地重点领域建设[ZY(2021-2023)-0201-06],项目负责人:肖涟波;上海市自然基金面上项目(22ZR1453000),项目负责人:沈军。; 背景:临床上补骨脂-淫羊藿治疗类风湿关节炎疗效明显,但两者所含有效成分复杂,在分子水平上治疗类风湿关节炎的作用机制仍不明确。目的:基于网络药理学和分子对接技术建立胶原诱导型关节炎模型,验证补骨脂-淫羊藿治疗类风湿关节炎可能...; 关键词：网络药理学分子对接补骨脂淫羊藿类风湿关节炎凋亡增殖体内实验胶原诱导型关节炎动物模型

Electrolyte engineering and material modification for graphite-based lithium-ion batteries operated at low temperature被引量：1: 《Interdisciplinary Materials》2023年第4期569-588,共20页Yue Yin Xiaoli Dong; supported by the National Key Research and Development Program of China(2022YFB3803400);National Natural Science Foundation of China(22109028);Natural Science Foundation of Shanghai(22ZR1404400);Chenguang Program sponsored by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(19CG01).; Graphite offers several advantages as an anode material,including its low cost,high theoretical capacity,extended lifespan,and low Li+-intercalation potential.However,the performance of graphite-based lithium-ion batt...; 关键词：graphite-based lithium-ion batteries low temperature material modification solid electrolyte interface solvation structure

Dual atomic catalysts from COF-derived carbon for CO_(2)RR by suppressing HER through synergistic effects被引量：2: 《Carbon Energy》2023年第6期92-103,共12页Minghao Liu Sijia Liu Qing Xu Qiyang Miao Shuai Yang Svenja Hanson George Zheng Chen Jun He Zheng Jiang Gaofeng Zeng; Q.Xu acknowledges financial support from the Natural Science Foundation of Shanghai(20ZR1464000);G.Zeng is grateful for the support from the National Natural Science Foundation of China(21878322,22075309);the Science and Technology Commission of Shanghai(19ZR1479200).The authors also thank the Shanghai Synchrotron Radiation Facility for XAFS measurements at Beamline BL14w1.; The electrochemical carbon dioxide reduction reaction(CO_(2)RR)for highvalue-added products is a promising strategy to tackle excessive CO_(2) emissions.However,the activity of and selectivity for catalysts for CO_(2)...; 关键词：carbon dioxide reduction reaction covalent-organic frameworks dual atomic catalysts metal-organic frameworks single-atom catalysts

High-intensity swimming alleviates nociception and neuroinflammation in a mouse model of chronic postischemia pain by activating the resolvin E1-chemerin receptor 23 axis in the spinal cord被引量：2: 《Neural Regeneration Research》2023年第11期2535-2544,共10页Xin Jia Ziyang Li Xiafeng Shen Yu Zhang Li Zhang Ling Zhang; National Key R&D Program of China,Nos.2019YFA0110300 (to LZ),2021YFA1201400 (to LZ);Natural Science Foundation of Shanghai,No.21ZR1468600 (to LZ);Open Fund of the Key Laboratory of Cellular Physiology (Shanxi Medical University),Ministry of Education,No.KLMEC/SXMU-201910 (to XJ)。; Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that ...; 关键词：central sensitization chemerin receptor 23 chronic post-ischemia pain complex regional pain syndrome exercise-induced analgesia microglia NEUROINFLAMMATION resolvin E1 spinal cord SWIMMING

外胚叶发育不全基因A突变导致家族性非综合征型先天缺牙的初步研究: 《口腔疾病防治》2023年第11期768-773,共6页王慧慧吴情徐斌凌琪吴轶群; 上海市自然科学基金(21ZR1437700);上海市闵行区自然科学研究课题(2020MHZ030)。; 目的寻找非综合征型先天缺牙(non-syndromic tooth agenesis,NSTA)家系的致病基因,探讨其发病机制。方法获得医院伦理审批及患者与家属知情同意,收集先证者及其家系主要成员的临床资料,采集外周静脉血,提取DNA,利用全外显子测序技术...; 关键词：外胚叶发育不全基因A 非综合征型先天缺牙综合征型先天缺牙多数牙缺失个别牙缺失全外显子测序 Sanger测序基因组DNA 基因突变错义突变

Altered gut microbiota composition in children and their caregivers infected with the SARS‑CoV‑2 Omicron variant: 《World Journal of Pediatrics》2023年第5期478-488,共11页Yi‑Zhong Wang Jian‑Guo Zhou Yan‑Ming Lu Hui Hu Fang‑Fei Xiao Ting Ge Xing Wang Lu Zheng Lian‑Hu Yu Jun Le Hui Yu Guang‑Jun Yu Qiang Xia Ting Zhang Wen‑Hao Zhou; supported by the grants from the National Natural Science Foundation of China(No.81870373);the Natural Science Foundation of Shanghai(No.22ZR1451800).; Background Gut microbiota alterations have been implicated in the pathogenesis of coronavirus disease 2019(COVID-19).This study aimed to explore gut microbiota changes in a prospective cohort of COVID-19 children and ...; 关键词：CAREGIVERS CHILDREN Coronavirus disease 2019(COVID-19) Gut microbiota Severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)

遥感SiCH-2卫星光学系统“猫眼”效应的卫星激光测距: 《地球与行星物理论评（中英文）》2023年第5期581-586,共6页龙明亮张海峰林海生吴志波邓华荣秦思张忠萍; 上海市自然科学基金面上资助项目(20ZR1467500);国家自然科学基金资助项目(12003056,11903066);上海市科技创新行动仪器共享配套操作与应用资助项目(21142201900)。; 乌克兰地球遥感卫星SiCH-2由2011年发射升空,目前已停止工作,处于失效失控状态,作为空间碎片目标由北美防空司令部(NORAD)提供两行根数(TLE)预报.本文分析了光学系统的“猫眼”效应,以上海天文台卫星激光测距(SLR)系统实现对SiCH-2卫星...; 关键词：卫星激光测距空间碎片光电探测设备 “猫眼”效应

Metal organic polymers with dual catalytic sites for oxygen reduction and oxygen evolution reactions被引量：4: 《Carbon Energy》2023年第5期127-137,共11页Sijia Liu Minghao Liu Xuewen Li Shuai Yang Qiyang Miao Qing Xu Gaofeng Zeng; support from the Natural Science Foundation of Shanghai (20ZR1464000);G.Zeng acknowledges the support from the National Natural Science Foundation of China (21878322,22075309);the Science and Technology Commission of Shanghai Municipality (19ZR1479200,22ZR1470100)。; Metal-organic frameworks and covalent organic frameworks have been widely employed in electrochemical catalysis owing to their designable skeletons,controllable porosities,and well-defined catalytic centers.However,th...; 关键词：covalent organic frameworks metal organic polymers oxygen evolution reaction oxygen reduction reaction single atom catalysts

Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease被引量：1: 《Neural Regeneration Research》2023年第9期2019-2028,共10页Li-Fen Liu Yu-Tong Liu Dan-Dan Wu Jie Cheng Na-Na Li Ya-Ni Zheng Liang Huang Qiong-Lan Yuan; supported by the Notional Natural Science Foundation of China,Nos.81371213 and 8107098 7;the Natural Science Foundation of Shanghai,No.21ZR1468400 (all to QLY)。; Extracellular amyloid beta(Aβ) plaques are main pathological feature of Alzheimer’s disease.However,the specific type of neuro ns that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown.In...; 关键词：5-hydroxytryptamin receptor 3 Alzheimer’s disease amyloid beta plaques CALCINEURIN cognitive deficits HTR3 interneurons iCa2+ nuclear factor of activated T-cells transgenic amyloid precursor protein and presenilin-1 mice TROPISETRON

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