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国家自然科学基金(30670094): 作品数：13被引量：23H指数：4; 导出分析报告; 相关作者：车艳春刘龙丁李琦涵李卫中余娴更多>>; 相关机构：中国医学科学院北京协和医学院川北医学院更多>>; 相关期刊：《Science China(Life Sciences)》《Virologica Sinica》更多>>; 相关主题：HSV-1TRANSCRIPTIONAL_REGULATIONICP22MIRNASVIRAL更多>>; 相关领域：生物学医药卫生农业科学更多>>

A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes被引量：6: 《Science China(Life Sciences)》2013年第4期373-383,共11页WU WenJuan GUO ZhongPing ZHANG XueMei GUO Lei LIU LongDing LIAO Yun WANG JingJing WANG LiChun LI QiHan; supported by the National Natural Science Foundation of China (30670094, 30700028);National Basic Research Program of China (2012CB518901, 2011CB504903); Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. ...; 关键词：herpes simplex virus I （HSV-1） microRNAs （miRNAs） cellular transcriptional repressor Kelch-like 24

The miRNAs of Herpes Simplex Virus(HSV)被引量：5: 《Virologica Sinica》2012年第6期333-338,共6页Le Sun Qihan Li; supported by the National Natural Sciences Foundation of China(No.30670094 and 30700028);Youth Science Research Foundation of PUMC(No.2012X23); Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2.The prevalence of HSV is worldwide.It primarily infects humans through epithelial cells,when it introduces a latent in...; 关键词：Herpes simplex virus （HSV） MIRNAS Latency-associated transcript （LAT）

HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2被引量：3: 《Science China(Life Sciences)》2011年第4期359-365,共7页WU WenJuan YU Xian LI WeiZhong GUO Lei LIU LongDing WANG LiChun LI QiHan; supported by the National Natural Science Foundation of China(Grant Nos.30700028,30670094);the Doctoral Fund of Ministry of Education of China(Grant No.0060023008); The protein encoded by HSRG1(HSV-1 stimulation-related gene 1) is a virally induced protein expressed in HSV-1-infected cells.We have already reported that HSRG1 is capable of interacting with transcriptional regulato...; 关键词：herpes simplex virus 1 HSRG1 Cyclin T2 transcriptional regulation

Transcriptional Regulation by HSV-1 Induced HTRP via Acetylation System: 《Virologica Sinica》2010年第6期417-424,共8页Jie CHEN Yan-mei LI Jian-feng LI Long-ding LIU Yun LIAO Rui-xiong NA Jing-jing WANG Li-chun WANG Qi-han LI; The National Natural Science Foundation of China (30670094);the Ph.D. Programs Foundation of Ministry of Education of China (20060023008); The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells.HTRP was found to interact with SAP30 (mSi...; 关键词：Herpes simplex virus type 1 （HSV-1） HTRP SAP30 Transcription regulation

Analysis of the Cellular Localization of Herpes Simplex Virus 1 Immediate-early Protein ICP22: 《Virologica Sinica》2010年第3期158-167,共10页Wei CUN Jie CHEN Ying ZHANG Long-ding LIU Qi-han LI; The National Natural Science Foundation of China (30670094, 30700028);the Ph.D. Programs Foundation of Ministry of Education of China (2006-0023008); Nuclear proteins often form punctiform structures, but the precise mechanism for this process is unknown. As a preliminary study, we investigated the aggregation of an HSV-1 immediate-early protein, infected-cell prot...; 关键词：Herpes Simplex Virus 1 （HSV-1） ICP22 Transcriptional regulation Cellular localization Nuclear functional domain

Transcriptional regulation of the Herpes Simplex Virus 1α-gene by the viral immediate-early protein ICP22 in association with VP16被引量：4: 《Science China(Life Sciences)》2009年第4期344-351,共8页CUN Wei, GUO Lei, ZHANG Ying, LIU LongDing, WANG LiChun, LI JianFeng, DONG ChengHong, WANG JinJin & LI QiHan Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China; Supported by the National Natural Science Foundation (Grant No. 30570081, 30670094);Doctoral Fund of Ministry of Education of China (Grant No. 20060023053); Herpes Simplex Virus 1 (HSV1) is capable of inducing two forms of infection in individuals, and the establishment of which type of infection occurs is linked to the transcriptional activation of viral α genes. One of...; 关键词：HERPES SIMPLEX virus ICP22 transcription VP16 α GENE

Molecular Modification of a HSV-1 Protein and Its Associated Gene Transcriptional Regulation: 《Virologica Sinica》2008年第6期394-398,共5页Yan-chun CHE Li JIANG Qi-han LI; National Natural Science Foundation of China (30670094,30700028); The molecular modifications of Herpes Simplex Virus Type I （HSV-1） proteins represented by acetylation and phosphorylation are essential to its biological functions. The cellular chromatin-remodeling/ assembly is in...; 关键词：MODIFICATION Herpes simplex virus type （HSV- 1） Transcriptional regulation

HSV-1间层蛋白VP22转录调控功能的分析被引量：2: 《中国科学（C辑）》2008年第9期787-793,共7页余娴李卫中刘龙丁车艳春寸伟吴文娟何春艳邵聪文李琦涵; 国家自然科学基金(批准号:30570081,30670094和30700028)资助项目; HSV-1间层蛋白是一类重要的功能蛋白,在病毒复制的多个环节中具有重要意义.为了解主要间层蛋白VP22在病毒复制过程中的生物学特性,本实验利用氯霉素乙酰转移酶系统,分析了VP22对病毒启动子的转录调控功能,结果表明VP22对HSV-1α4,TK和g...; 关键词：HSV-1 间层蛋白 VP22转录调控

Functional analysis of transcriptional regulation of herpes simplex virus type 1 tegument protein VP22被引量：4: 《Science China(Life Sciences)》2008年第11期966-972,共7页YU Xian1,2, LI WeiZhong1, LIU LongDing1, CHE YanChun1, CUN Wei1, WU WenJuan1, HE ChunYan1, SHAO CongWen1 & LI QiHan1 1 Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China 2 Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China; the National Natural Science Foundation of China (Grant Nos. 30570081,30670094 and 30700028); The herpes simplex virus type 1 (HSV-1) tegument proteins have important functions in the viral repli- cation process. In order to investigate the role of the HSV-1 tegument protein VP22 in viral replication, its tran...; 关键词：HERPES SIMPLEX virus type 1 TEGUMENT VP22 TRANSCRIPTIONAL regulation

Interactions of the HSV-1 UL25 Capsid Protein with Cellular Microtubule-associated Protein: 《Virologica Sinica》2008年第3期211-217,共7页Lei GUO Ying ZHANG Yan-chun CHE Wen-juan WU Wei-zhong LI Li-chun WANG Yun LIAO Long-ding LIU Qi-han LI; National Natural Science Funds(30570081, 30670094 and 30700028); An interaction between the HSV-1 UL25 capsid protein and cellular microtubule-associated protein was found using a yeast two-hybrid screen and β-D-galactosidase activity assays. Immunofluorescence microscopy of the U...; 关键词：HSV-1 CAPSID UL25 Microtubule-associated protein

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