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国家高技术研究发展计划(2011AA10A207): 作品数：13被引量：60H指数：5; 导出分析报告; 相关作者：钱旭红石延霞李宝聚谢学文李忠更多>>; 相关机构：华东理工大学中国农业科学院蔬菜花卉研究所沈阳农业大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《果树学报》《中国蔬菜》《药学学报》更多>>; 相关主题：SCAFFOLD3-DPLANTACTIVATORACTIVATORS更多>>; 相关领域：化学工程农业科学医药卫生理学更多>>

C11 , a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis被引量：3: 《Acta Pharmacologica Sinica》2019年第6期823-832,共10页Zhuo Chen Lin-jiang Tong Bai-you Tang Hong-yan Liu Xin Wang Tao Zhang Xian-wen Cao Yi Chen Hong-lin Li Xu-hong Qian Yu-fang Xu Hua Xie Jian Ding; National Natural Science Foundation of China (grants 81173080, 81321092, 21236002 and 21302054);National Basic Research Program of China (973 Program, 2010CB126100);National High Technology Research and Development Program of China (863 Program, 2011AA10A207);National Science & Technology Pillar Program (2009ZX09103-102);Shanghai Committee of Science and Technology (grant 13ZR1453100);Fundamental Research Funds for the Central Universities.; The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new sele...; 关键词：C11 FGFR1 INHIBITOR ANTITUMOR BREAST cancer metastasis ANGIOGENESIS

The discovery of new scaffold of plant activators：From salicylic acid to benzotriazole: 《Chinese Chemical Letters》2017年第4期919-926,共8页Kang Chang Jian-Qin Chen Yan-Xia Shi Mei-Jian Sun Peng-Fei Li Zhen-Jiang Zhao Wei-Ping Zhu Hong-Lin Li Yu-Fang Xu Bao-Ju Li Xu-Hong Qian; financially supported by the National Basic Research Program of China(973 Program,No.2010CB126100);the National High Technology Research and Development Program of China(863 Program,No.2011AA10A207);the Shanghai Leading Academic Discipline Project(B507);the Fundamental Research Funds for the Central Universities; Started from salicylic acid（SA） and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison（SHAFTS）,a new lead compound benzotriazole was predicted...; 关键词：Plant activator Systemic acquired resistance Salicylic acid Benzotriazole Virtual screening

Synthesis and insecticidal evaluation of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one derivatives: 《Chinese Chemical Letters》2016年第1期7-10,共4页Xuan-Qi Liu Ya-Qin Liu Xu-Sheng Shao Zhi-Ping Xu Xiao-Yong Xu Zhong Li; financial supported by National High Technology Research Development Program of China (863 Program, No. 2011AA10A207);National Natural Science Foundation of China (Nos. 21472046, 21372079);Shanghai Pujiang Program (No. 14PJD012);the Fundamental Research Funds for the Central Universities (No. 222201414015);partly supported by Australia DC Foundation; A series of novel tetrahydroimidazo[1,2-a]pyridine-5（1H）-one derivatives containing a electronegative pharmacophore（=CNO_2） were synthesized via practical aza-ene reaction and characterized by ~1H NMR,^（13）C NM...; 关键词：NEONICOTINOIDS Tetrahydroimidazo[1 2-a]pyridin-5（1H） ONE Configuration Insecticidal activity

A novel and facile synthesis of 2-oxo-1,2-dihydropyridine-fused 1,3-diazaheterocycles via heterocyclic ketene aminals and Konevenagel adducts formed by phthalic anhydride and ethyl cyanacetate: 《Chinese Chemical Letters》2014年第12期1515-1519,共5页Min-Ming Zou Feng-Juan Zhu Xue Tian Li-Ping Ren Xu-Sheng Shao Zhong Li; financial supported by National Natural Science Foundation of China(No.21372079);National High Technology Research Development Program of China(863 Program,No. 2011AA10A207);Shanghai Pujiang Program(No.14PJD012);Key Projects in the National Science & Technology Pillar Program(No. 2011BAE06B05);the Fundamental Research Funds for the Central Universities;partly supported by Australia DC Foundation; An efficient synthetic pathway to 2-oxo-1,2-dihydropyridine-fused 1,3-diaza heterocycles from heterocyclic ketene aminals,phathalic anhydride and ethyl cyanacetate was established.This protocol involved aza-ene reacti...; 关键词：Heterocyclic ketene aminals 2-Oxo-1 2-dihydropyridine 1 3-Diazaheterocycle Synthesis

Design,synthesis and insecticidal activity of spiro heterocycle containing neonicotinoid analogs被引量：5: 《Chinese Chemical Letters》2014年第2期197-200,共4页Nan-Yang Chen Li-Ping Ren Min-Ming Zou Zhi-Ping Xu Xu-Sheng Shao Xiao-Yong Xu Zhong Li; financial supported by National Basic Research Program of China(973 Program,No.2010CB126100);National High Technology Research Development Program of China(863 Program,No.2011AA10A207);Key Projects in the National Science & Technology Pillar Program(No.2011BAE06B05);National Natural Science Foundation of China(No.21372079);Shanghai Education Committee(No.12ZZ057);the Fundamental Research Funds for the Central Universities;partly supported by Australia DC Foundation; Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenon...; 关键词：NEONICOTINOID Spiro heterocycle Activity INSECTICIDE

Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold: Synthesis and bioactivity被引量：4: 《Chinese Chemical Letters》2013年第11期967-969,共3页Qing-Shan Du Yan-Xia Shi Peng-Fei Li Zhen-Jiang Zhao Wei-Ping Zhu Xu-Hong Qian Bao-Ju Li Yu-Fang Xu; financially supported by the National Basic Research Program of China (973 Program, No. 2010CB126100);the National High Technology Research and Development Program of China (863 Program, No. 2011AA10A207);the China 111 Project (No. B07023);the Fundamental Research Funds for the Central Universities.; The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were d...; 关键词：Thieno[2 3-d]-1 2 3-thiadiazole-6-carboxylate derivatives Plant activator Systemic acquired resistance

Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold被引量：11: 《Chinese Chemical Letters》2013年第8期673-676,共4页Yin-Bo Chen Ji-Ling Li Xu-Sheng Shao Xiao-Yong Xu Zhong Li; supported by National Basic Research Program of China(973 Program,No.2010CB126100);National High Technology Research and Development Program of China (863 Program,No.2011AA10A207);supported by National Key Technology R&D Program of China(No. 2011BAE06B01); A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~...; 关键词：Anthranilic diamides Benzyl sulfide Synthesis Insecticidal activity

4种诱抗剂诱导番茄抗晚疫病的初步效果被引量：19: 《中国蔬菜》2013年第06X期49-54,共6页李少波石延霞刘君丽谢学文李宝聚; 国家高技术研究发展计划项目(2011AA10A207);国家现代农业产业技术体系专项(CARS-25-B-04);农业部园艺作物生物学与种质创制重点实验室资助项目; 为了明确苯并噻二唑、香菇多糖、几丁聚糖和氨基寡糖素对番茄晚疫病(Phytophthora infestans)的作用效果,测定了这4种诱抗剂对番茄晚疫病菌的抑菌活性,并通过盆栽和田间试验明确了4种诱抗剂对番茄晚疫病的诱导抗性。抑菌活性测定结果表...; 关键词：番茄晚疫病诱抗剂诱导抗病性

甜瓜白粉病防治药剂活体筛选模型研究被引量：2: 《果树学报》2013年第5期893-897,I0004,共6页所凤阅唐莎莎石延霞谢学文李宝聚; 公益性行业(农业)科研专项(2010CB126101);国家"973"项目(2010CB126101);十二五"863"课题(2011AA10A207);农业部园艺作物生物学与种质创制重点实验室; 【目的】寻找新的甜瓜白粉病杀菌剂筛选方法。【方法】在不同品种和不同部位的甜瓜叶片上接种白粉病菌，并在不同的温度和光照条件下培养。【结果】选用厚皮甜瓜真叶叶盘（4cm×2cm）为试材，从叶盘背面喷雾接种白粉病菌的孢子悬浮液，...; 关键词：甜瓜白粉病活体微量筛选模型离体叶盘

Comparative and statistical analysis of nAChR sequences: An ab initio approach to the origin of molecular discrimination: 《Chinese Science Bulletin》2012年第5期479-486,共8页WANG YanLi LI Zhong QIAN XuHong; supported by the National Basic Research Program of China (2010CB126100);the National High Technology Research and Development Program of China (2011AA10A207);supported by the National Key Technology R&D Program of China (2011BAE06B01);the Shanghai Leading Academic Discipline Project (B507);the Fundamental Research Funds for the Central Universities, China; Compared with traditional structure-based approaches for the identification of species-specific ligands, the ab initio approach, based on large-scale protein sequences from different species, has been used to locate s...; 关键词：乙酰胆碱受体蛋白质序列分子选择性统计分析从头算方法物种特异性从头计算方法结构信息

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