云南高校图书馆联盟文献共享服务平台- 上海市教育委员会重点学科基金(B906)

上海市教育委员会重点学科基金(B906): 作品数：64被引量：249H指数：9; 导出分析报告; 相关作者：陈海生盛春泉柴晓云俞世冲吴秋业更多>>; 相关机构：第二军医大学空军总医院重庆邮电大学首都医科大学更多>>; 相关期刊：《Chemical Research in Chinese Universities》《中国药学杂志》《中国新药杂志》《高等学校化学学报》更多>>; 相关主题：化学成分抗真菌活性2-丙醇1H-1,2,4-三唑二氟苯基更多>>; 相关领域：医药卫生理学生物学化学工程更多>>

抗肿瘤天然产物汉黄芩素的合成被引量：1: 《有机化学》2016年第12期2960-2964,共5页袁虎叶霁陈浩赵增李玉柱张卫东孙青龑; 长江学者奖励计划;国家自然科学基金(Nos.81520108030;81573318;81373301;1302658);上海市重点学科建设(No.B906);上海活性天然产物制备工程研究中心(No.10DZ2251300)资助项目~~; 汉黄芩素(wogonin,5,7-二羟基-8-甲氧基黄酮)是传统中草药黄芩的有效成分之一,其抗肿瘤活性显著,且对肿瘤细胞的杀伤作用有其独特的机制.目前报道的化学合成法大多总收率较低,反应条件苛刻或原料来源困难.笔者以2,4-二苄氧基-6-羟基苯...; 关键词：抗肿瘤汉黄芩素硼酸酯化合成

Two new cyclic bisbibenzyl derivatives from Hebertus dicranus: 《Chinese Journal of Natural Medicines》2016年第6期457-461,共5页XU Chang-Long WANG Jin-Xin LI Hui-Liang; supported by program NCET Foundation,National Natural Science Foundation of China(Nos.81230090,81102335,and 81473109);Shanghai Leading Academic Discipline Project(B906);Key Laboratory of Drug Research for Special Environments,PLA,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(10DZ2251300);the Scientific Foundation of Shanghai China(Nos.12401900801,13401900101);National Major Project of China(No.2011ZX09307-002-03);the National Key Technology R&D Program of China(No.2012BAI29B06);the National Natural Science Foundation of China(No.21161009);the Natural Science Foundation of Jiangxi Province(No.20132BAB203004); In the present study, two new cyclic bisbibenzyls(1, 2) co-occuring with a known compound, isoplagiochins C(3) were isolated from Hebertus dicranus. The structures were determined mainly by extensive 1D and 2D NMR exp...; 关键词：Hebertus dicranus Cyclic bisbibenzyl Circular dichroism spectrum

Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins被引量：9: 《Chinese Journal of Natural Medicines》2015年第9期660-666,共7页ZHANG Shou-De SHAN Lei LI Wei LI Hong-Lin ZHANG Wei-Dong; supported by the National Natural Science Foundation of China(Nos.81302651,81230090,and 81222046);the Fundamental Research Funds for the Central Universities(No.222201314041);the Global Research Network for Medicinal Plants(GRNMP);King Saud University,the Shanghai Leading Academic Discipline Project(No.B906);the Key Laboratory of Drug Research for Special Environments,PLA,the Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300);the Scientific Foundation of Shanghai China(Nos.12401900801,09DZ1975700,09DZ1971500,and 10DZ1971700); The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L.(Thymelaeaceae) that is used in traditional Chinese medicine(TCM) to treat tumors, tuberculosis, and psoriasis. Herein, isoch...; 关键词：Stellera chamaejasme L. Isochamaejasmin Bcl-2 3D Similarity search （–）-Gossypol Apoptosis

天然产物文殊兰新碱的全合成研究: 《药学实践杂志》2015年第4期331-333,共3页陈浩叶霁刘江云张卫东孙青龑; 国家自然科学基金(81230090);上海市重点学科建设项目(B906); 目的开展文殊兰新碱的全合成工作。方法以3,4-亚甲二氧基苯乙胺和2,5-二甲氧基苯乙酸为起始原料,经缩合、环合、还原和氧化等反应。结果与结论完成了文殊兰新碱的全合成,确定了其最佳合成路线,总收率为73%。; 关键词：生物碱文殊兰新碱全合成

氯化两面针碱合成方法的改进被引量：2: 《有机化学》2015年第6期1353-1356,共4页许旭升刘志千邵文浩叶霁孙青龑何薇薇张卫东; 国家自然科学基金(81230090);上海市重点学科建设(No.B906)资助项目~~; 以6-溴-3,4-二甲氧基苯甲醛和6,7-亚甲二氧基-1-萘胺为起始原料,经还原胺化、分子内Heck偶联、氧化芳构化、甲基化以及离子交换等五步反应,完成了氯化两面针碱的合成,并对关键步骤分子内Heck偶联反应条件进行了探索,结果表明该偶联反应...; 关键词：氯化两面针碱分子内Heck偶联反应合成改进

Metabolomic Study of Biochemical Changes Related to Toxicity Induced by Bupleurotoxin Using LC-MS Coupled with a Pattern Recognition Approach被引量：2: 《World Journal of Traditional Chinese Medicine》2015年第1期29-36,共8页Zhong-Xiao Zhang Juan Su Xin-Ru Liu Wei-Xing Dai Shi-Kai Yan Wei-Dong Zhang; supported by a program of the NCET Foundation,NSFC(81402823);partially supported by the Global Research Network for Medicinal Plants(GRNMP);by King Saud University,Shanghai Leading Academic Discipline Project(B906);FP7-PEOPLE-IRSES-2008(TCMCANCER Project 230232);the Key laboratory of drug research for special environments,PLA;the Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(10DZ2251300);the Scientific Foundation of Shanghai China(09DZ1975700,09DZ1971500,10DZ1971700);the National Major Project of China(2011ZX09307-002-03);the National Key Technology R&D Program of China(2012BAI29B06); The purpose of this study was to detect changes in urine of mice and to clarify the toxicity induced by bupleurotoxin(BETX) using liquid chromatography/quadrupole time-of-flight mass spectrometry(LC-Q-TOF-MS). A proce...; 关键词：bupleurotoxin metabolomic profiling TOXICITY BIOMARKER LC-Q-TOF-MS

微管蛋白聚合抑制剂OXi8006的合成新方法: 《有机化学》2015年第2期484-489,共6页刘春廷毕凯健畅婉琳叶霁张卫东孙青龑; 国家自然科学基金(No.81230090);上海市重点学科建设(No.B906)资助项目~~; 2-(3'-羟基-4'-甲氧基苯基)-3-(3",4",5"-三甲氧基苯甲酰基)-6-甲氧基吲哚(OXi8006)能够有效抑制微管蛋白聚合,而表现出良好抗癌活性.目前报道的OXi8006全合成路线较长、总收率低,且反应条件苛刻.为了更高效地合成该化合物,从而为进一...; 关键词：微管蛋白聚合抑制剂 OXi8006 杂迈克尔加成 HECK反应

“Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives被引量：18: 《Chinese Journal of Natural Medicines》2015年第1期3-21,共19页YAN Shi-Kai LIU Run-Hui JIN Hui-Zi LIU Xin-Ru YE Ji SHAN Lei ZHANG Wei-Dong; supported by Professor of Chang Jiang Scholars Program,NSFC(No.81230090);Shanghai Leading Academic Discipline Project(B906);Key laboratory of drug research for special environments,PLA,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300);the Scientific Foundation of Shanghai,China(Nos.12401900801,13401900 101);National Major Project of China(No.2011ZX09307-002-03);the National Key Technology R&D Program of China(No.2012BAI29B06); In the post-genomic era, biological studies are characterized by the rapid development and wide application of a series of "omics" technologies, including genomics, proteomics, metabolomics, transcriptomics, lipidomic...; 关键词：OMICS GENOMICS TRANSCRIPTOMICS PROTEOMICS Metabolomics Target Discovery Toxicity Assessment PersonalizedMedicine Traditional Chinese Medicine

Bioanalysis and Pharmacokinetics of Eight Active Components from Huanglian Jiedu Decoction in Rat Plasma by LC-ESI-MS/MS Method被引量：6: 《Chinese Herbal Medicines》2014年第3期198-210,共13页Cheng-cheng Peng Shu-ping Wang Hui-zi Jin Jian-fei Tao Guo-wei Wang Pan-lei Wei Xu-feng Zhang Le Li Run-hui Liu Wei-dong Zhang; Program NCET Foundation NSFC(81230090);Global Research Network for Medicinal Plants and King Saud University,Shanghai Leading Academic Discipline Project(B906);Key laboratory of drug research for special environments,PLA,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(10DZ2251300);Scientific Foundation of Shanghai China(12401900801,09DZ1975700,09DZ1971500,10DZ1971700);National Major Project of China(2011ZX09307-002-03);National Key Technology R&D Program of China(2012BAI29B06); Objective To develop a sensitive and rapid liquid chromatography-electrospray ionization-tandem mass spectrometry （LC-ESI-MS/MS） method for the simultaneous determination of wogonin, coptisine, berberine, palmatine,...; 关键词：ALKALOID BIOANALYSIS flavonoid Huanglian Jiedu Decoction LC-ESI-MS/MS PHARMACOKINETICS

新型三唑类抗真菌药物的合成及其抑菌活性研究: 《药学实践杂志》2013年第5期373-376,共4页庞涛吴茂诚王潇屹; 上海市重点学科资助项目(B906);上海科委基金资助项目(09dZ1976700);全军特殊环境重点研究实验室资助项目; 目的设计合成新的三氮唑类化合物,并对其进行体外抑菌活性研究。方法以1,3-二氟苯为原料,运用Click反应合成一系列目标化合物;用微量液体稀释法检测目标化合物,测定其体外抗真菌活性。结果合成了12个目标化合物;所有化合物对所选真菌均...; 关键词：三唑 CLICK反应抗真菌活性

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