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北京市自然科学基金(7120002): 作品数：11被引量：26H指数：3; 导出分析报告; 相关作者：王鹏刘芝华方伟岗郭永庆刘威更多>>; 相关机构：北京大学中国医学科学院北京协和医学院中日友好医院第三军医大学更多>>; 相关期刊：《Science China(Life Sciences)》《解剖学报》《Frontiers of Medicine》《中国科学：生命科学》更多>>; 相关主题：DLIKINN-CORRELATESMOUSE更多>>; 相关领域：医药卫生生物学更多>>

LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein被引量：2: 《Science China(Life Sciences)》2022年第1期129-141,共13页Siyuan Yang Weizhi Xu Cheng Liu Jiaqi Jin Xueying Li Yuhan Jiang Lei Zhang Xianbin Meng Jun Zhan Hongquan Zhang; supported by the National Natural Science Foundation of China(81730071,81972616,81230051,81472734,31170711 and 81773199);the Ministry of Science and Technology of China(2016YFC1302103 and 2015CB553906);Beijing Natural Science Foundation(7120002 and 7171005);Peking University(BMU2018JC004,BMU20120314 and BMU20130364)。; Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 st...; 关键词：LATS1 acetylation LATS1 activation and inhibition Hippo signalling pathway lung adenocarcinoma

细胞分裂周期相关蛋白7通过增强细胞增殖和干性促进人乳腺癌进程被引量：2: 《解剖学报》2020年第6期888-896,共9页杨得草刘程马集王梦远战军张宏权; 国家自然科学基金(81230051,81472734,31170711,81321003,81773199,30830048);科技部专项基金(2016YFC1302103,2015CB553906);北京市自然科学基金(7120002)。; 目的探讨细胞分裂周期相关蛋白7(CDCA7)在人类乳腺癌中的相关功能及潜在的作用机制。方法通过癌症和肿瘤基因图谱(TCGA)数据库分析检索出不同乳腺癌亚型差异表达基因,找到在基底型乳腺癌中高表达基因,在这些基因中找到CDCA7,通过临床患...; 关键词：细胞分裂周期相关蛋白7 Basal-like/luminal乳腺癌干细胞 Β-连环蛋白流式细胞术人

C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision被引量：2: 《Science China(Life Sciences)》2019年第9期1229-1242,共14页Ji Ma Cheng Liu Decao Yang Jiagui Song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang; supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z;a grant from the National Natural Science Foundation of China (81773199) to J.Z; Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...; 关键词：C1orf106 BASAL-LIKE LUMINAL PROGENITOR breast cancer ELF5 GATA3

G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma被引量：2: 《Frontiers of Medicine》2019年第4期482-491,共10页Wenjing Wang Shigang Ding Hejun Zhang Jun Li Jun Zhan Hongquan Zhang; This study was supported by grants from the Ministry of Science and Technology ofChina (Nos. 2016YFC1302103,2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (Nos. 81230051, 81472734, 31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (No. 7120002);the 111 Project of the Ministry of Education, Peking University (Nos. BMU20120314 and BMU20130364);and the Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang.; LGR6 is a member of the G protein-coupled receptor family that plays a tumor-suppressive role in colon cancer. However, the relationship between LGR6 expression in patients and clinicopathological factors remains uncl...; 关键词：LGR6 COLON ADENOCARCINOMA IMMUNOHISTOCHEMISTRY PROGNOSIS

Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice被引量：6: 《Science China(Life Sciences)》2019年第2期225-234,共10页Bing Li Xiaochun Chi Jiagui Song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang; supported by grants from the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906, and 2013CB910501);the National Natural Science Foundation of China (81730071, 81230051, 81472734, and 31170711);the Beijing Natural Science Foundation (7120002 and 7171005);the 111 Project of the Ministry of Education, grants from Peking University (BMU20120314 and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z.;supported by a grant from the National Natural Science Foundation of China (81773199) to J.Z; Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a...; 关键词：Kindlin-2 breast cancer MOUSE MAMMARY GLAND growth MAMMARY TUMORIGENESIS TRANSGENIC MOUSE

Kindlin-1和Kindlin-2的差异表达与食管癌的进程及流行病学特点的相关性被引量：3: 《中国科学：生命科学》2018年第1期93-101,共9页王鹏战军宋佳桂王允玲方伟岗刘芝华张宏权; 中国科技部基金(批准号：2016YFC1302103,2015CB553906,2013CB910501); 国家自然科学基金(批准号：81230051,81472734,31170711,81321003,81301802,30830048); 北京自然科学基金(批准号：7120002); 北京大学教育部111项目(批准号：BMU20120314,BMU20130364); 北京教育局领导学科项目资助; 食管癌是中国最致命的恶性肿瘤之一,但其病因和危险因素的分子机制仍不清楚.整合素相互作用蛋白Kindlin-1和Kindlin-2可以激活跨膜受体整合素,调节肿瘤细胞的生长、侵袭和转移.本研究首次发现,在中国食管癌患者中,Kindlin-1和Kindlin-2...; 关键词：Kindlin-1 Kindlin-2 食管癌流行病学

Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology被引量：1: 《Science China(Life Sciences)》2017年第11期1214-1222,共9页peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang; supported by the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906. 2013CB910501);the National Natural Science Foundation of China (81230051, 81472734, 31170711, 81321003, 81301802, 30830048);Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU20120314, BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang; Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that a...; 关键词：Kindlin-l Kindlin-2 esophageal cancer EPIDEMIOLOGY

Depletion of Kindlin-2 induces cardiac dysfunction in mice被引量：1: 《Science China(Life Sciences)》2016年第11期1123-1130,共8页Lihua Qi Yu Yu Xiaochun Chi Danyu Lu Yao Song Youyi Zhang Hongquan Zhang; supported by the Ministry of Science and Technology of China(2015CB553906,2013CB910501);the National Natural Science Foundation of China(81500180,81230051,81472734,31170711,81321003,30830048);Beijing Natural Science Foundation(7120002);the 111 Project of the Ministry of Education,Peking University(BMU20120314,BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang; Kindlin-2, a member of the Kindlin family focal adhesion proteins, plays an important role in cardiac development. It is known that defects in the Z-disc proteins lead to hypertrophic cardiomyopathy(HCM) or dilated ca...; 关键词：Kindlin-2 depletion myocardial hypertrophy cardiac dysfunction MOUSE

Kindler syndrome protein Kindlin-1 is mainly expressed in adult tissues originating from ectoderm/endoderm被引量：1: 《Science China(Life Sciences)》2015年第5期432-441,共10页ZHAN Jun YANG Mei ZHANG Jing GUO YongQing LIU Wei ZHANG HongQuan; supported by the National Natural Science Foundation of China(81301802,81230051,30830048,31170711);Grant of Ministry of Science and Technology of China(2013CB910501,2010CB912203,2010CB529402);Program for Introducing Talents of Discipline to Universities(111 Project)of Ministry of Education;Beijing Natural Science Foundation(7120002);Peking University grants(BMU20120314,BMU20130364,BMU20130373);a Leading Academic Discipline Project of Beijing Education Bureau; Mutations of integrin-interacting protein Kindlin-1 cause Kindler syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However, Ki...; 关键词：Kindlin- 1 epithelial tissue ECTODERM ENDODERM embryo

Kindler综合征蛋白Kindlin-1在人体内、外胚层来源的组织中表达: 《中国科学：生命科学》2015年第1期25-34,共10页战军杨枚张京郭永庆刘威张宏权; 国家自然科学基金(批准号:81301802;81230051;81301802;31170711;30830048);国家重点基础研究发展计划(批准号:2015CB553906;2013CB910501;2010CB912203);北京自然科学基金(批准号:7120002);教育部高等学校学科创新引智计划;北京大学教师启动基金(批准号:BMU20120314;BMU20130364;BMU20130373);北京教育局学科建设项目资助; 整合素相互作用蛋白Kindlin-1的基因突变可导致Kindler综合征.在肿瘤中,Kindlin-1的表达会发生失衡.Kindlin-1相关疾病通常只发生于一些特定的组织器官中.迄今,关于Kindlin-1的组织分布规律及正常人体如何控制Kindlin-1表达的规律还不清...; 关键词：Kindlin-1 上皮组织外胚层内胚层胚胎

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