国家自然科学基金(s30470405)

作品数:10被引量:8H指数:2
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相关期刊:《Chemical Research in Chinese Universities》《Science Bulletin》更多>>
相关主题:AQUAPORINACTIVATORCFTRAQUAPORIN-1TRANSPORT更多>>
相关领域:医药卫生生物学轻工技术与工程更多>>
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Aquaporin-3 Deletion Reduces Glycerol and ATP Content in Mouse Sciatic Nerve被引量:2
《Chemical Research in Chinese Universities》2010年第6期955-957,共3页ZHANG Di GUO Lei ZHU Na SU Wei-heng GUAN Xin-gang YI Fei HAO Feng XIAO Ying-hong LIU Jia LIU Tian-zhou MA Tong-hui 
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405,30570864,30670477 and 30770493)and the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
We reported the expression and function of aquaglyceroporin AQP3 in mouse peripheral nervous system.AQP3 mRNA was identified in freshly isolated mouse sciatic nerve by RT-PCR.Immunofluorescence using AQP3 antibody loc...
关键词:AQUAPORIN Sciatic nerve myelin GLYCEROL ATP 
Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice
《Chemical Research in Chinese Universities》2010年第2期217-220,共4页ZHU Na QIAO Ying ZHANG Di WANG Wen-juan LIU Jia LIU Tian-zhou MA Tong-hui 
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405, 30570864,30670477 and 30770493);the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
Aquaporins(AQPs) are molecular water channels that play important physiological roles in fluid trans-porting organs. The expression and function of AQPs in the immune system are largely unknown. CD 11 (a-d)/CD18 i...
关键词:AQUAPORIN SPLENOCYTE CD1 lb Flow cytometry 
Activation of CFTR-mediated Cl^- Transport by Magnolin
《Chemical Research in Chinese Universities》2008年第2期187-191,共5页JIN Ling-ling LIU Xin SUN Yan LIN Sen ZHOU Na XU Li-na YU Bo HOU Shu-guang YANG Hong 
Supported by the National Natural Science Foundation of China(Nos30470405 and 30570864)
Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator(CFTR) is an epithelial chloride channel that plays a key rol...
关键词:Cystic fibrosis CFTR MUTATION Magnolin ACTIVATOR 
Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator
《Chemical Research in Chinese Universities》2008年第1期92-95,共4页HAO Li-ming LIU Xin XU Li-na ZHU Na LIN Sen HOU Shu-guang ZHOU Na SHI De-cheng SHANG De-jing MA Tong-hui YANG Hong 
National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore...
关键词:Cystic fibrosis CFTR MUTATION Natural compound ACTIVATOR 
Prokaryotic Expression,Purification,Antibody Production of a NH_2-Terminal Fragment of mCLCA3 Protein and Analysis of mClCA3 Protein Expression in Asthmatic Mouse Lung被引量:1
《Chemical Research in Chinese Universities》2007年第6期688-692,共5页HOU Xia WU Qing-tian ZHANG Yu-ping ZHU Na LIU Yan-li FENG Xue-chao MA Tong-hui 
Supported by the Distinguished Young Scholars Fund of China(No.30325011);the National Natural Science Foundation of China(Nos.30470405and30670477);Distinguished Young Scholars Fund of Jilin Province,China(No.20030112);Excellent Young Teachers Program of MOE,China.
mCLCA3 is a member of calcium activated chloride channel(CACC) family that may play an important role in mucin packaging and secretion in asthmatic and cystic fibrosis lung. To study the protein structure and expres...
关键词:mCLCA3 Prokaryotic expression PURIFICATION Antibody production ASTHMA 
Dictamine Stimulates Cystic Fibrosis Transmembrane Conductance Regulator Cl-Transport被引量:2
《Chemical Research in Chinese Universities》2007年第5期554-557,共4页LIU Jun LIU Li-dan WANG Su-mei XU Li-na YU Bo LIN Sen 
Supported by the National Natural Science Foundation of China(Nos.30470405and30570864).
Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz.In the present study,we found that dictamine is able to stimulate the chloride transport activity of wild-type and ΔF508 mutant CFTR.The a...
关键词:Cystic fibrosis CFI'R Dictamine ACTIVATOR 
Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice被引量:2
《Chemical Research in Chinese Universities》2007年第3期297-299,共3页WU Qing-tian MA Qing-jie HE Cheng-yan WANG Cai-xia GAO Shi HOU Xia MA Tong-hui 
Supported by the National Natural Science Foundation of China(Nos30470405 and 30670477);National Natural ScienceFund for Distinguished Young Scholars(No30325011);Distinguished Young Scholars Fund of Jilin Province(No20030112);Excellent Young Tea
An overt phenotype of aquaporin-1 knockout(AQP1 ko) mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density( BMD), bon...
关键词:AQUAPORIN Gene knockout Bone mineral density Bone metabolism 
Importance of NPA motifs in the expression and function of water channel aquaporin-1被引量:1
《Chinese Science Bulletin》2007年第6期771-776,共6页JIANG Yong MA TongHui 
Supported by the National Natural Science Foundation of China for Distinguished Young Scholars (Grant No. 30325011);National Natural Science Foundation of China (Grant Nos. 30470405 and 30670477);Distinguished Young Scholars Fund of Jilin Province (Grant No. 20030112);Excellent Young Teachers Program of Ministry of Education of China
The asparagine-proline-alanine sequences (NPA motifs) are highly conserved in aquaporin water channel family. Crystallographic studies of AQP1 structure demonstrated that the two NPA motifs are in the narrow central c...
关键词:水通道蛋白-1 NPA模体 基因表达 功能 突变发生 
Activation Effect of Cathartic Natural Compound Rhein to CFTR Chloride Channel
《Chemical Research in Chinese Universities》2006年第3期312-314,共3页SHI Lin-lin XU Li-na HOU Shu-guang LIN Sen YANG Hong MA Tong-hui 
SupportedbytheNationalNaturalScienceFundforDistinguishedYoungScholars(No.30325011),theNationalNaturalScienceFoundationofChina(Nos.30470405and30570864),DistinguishedYoungScholarsFundofJilinProvince(No.20030112),andExcellentYoungTeachersProgramofMOE,China.
The cystic fibrosis transmembrane conductance regulator (CFFR) is a cAMP-activated chloride channel expressed in intestinal exoerine glands, which plays a key role in intestinal fluid secretion. A natural anthraquin...
关键词:CFTR chloride channel ANTHRAQUINONE Laxative drug 
cDNA Cloning, Prokaryotic and Eukaryotic Expression and Characterization of Porcine Leukemia Inhibitory Factor
《Chemical Research in Chinese Universities》2006年第2期145-149,共5页LI Ming-tang JIANG Yong WANG Shu-mei LI Yong-ming WANG Fang HOU Xia YANG Hong MA Tong-hui 
SupportedbytheNationalNaturalScienceFundforDistinguishedYoungScholars(No.30325011),theNationalNaturalScienceFoundationofChina(Nos.30470405and30570864),DistinguishedYoungScholarsFundofJilinProvince(No.20030112)andExcellentYoungTeachersProgramofMOE,P.R.China.
Molecular cloning of the porcine leukemia inhibitor factor(pLIF) has not been reported. A full-length eDNA encoding pLIF was cloned, expressed and characterized. The full-length porcine LIF cDNA encodes a 202 amino ...
关键词:Leukemia inhibitor factor PORCINE CLONING Recombinant protein Embryonic stem cell PLURIPOTENCY 
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