Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405,30570864,30670477 and 30770493)and the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
We reported the expression and function of aquaglyceroporin AQP3 in mouse peripheral nervous system.AQP3 mRNA was identified in freshly isolated mouse sciatic nerve by RT-PCR.Immunofluorescence using AQP3 antibody loc...
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405, 30570864,30670477 and 30770493);the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
Aquaporins(AQPs) are molecular water channels that play important physiological roles in fluid trans-porting organs. The expression and function of AQPs in the immune system are largely unknown. CD 11 (a-d)/CD18 i...
Supported by the National Natural Science Foundation of China(Nos30470405 and 30570864)
Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator(CFTR) is an epithelial chloride channel that plays a key rol...
National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore...
Supported by the Distinguished Young Scholars Fund of China(No.30325011);the National Natural Science Foundation of China(Nos.30470405and30670477);Distinguished Young Scholars Fund of Jilin Province,China(No.20030112);Excellent Young Teachers Program of MOE,China.
mCLCA3 is a member of calcium activated chloride channel(CACC) family that may play an important role in mucin packaging and secretion in asthmatic and cystic fibrosis lung. To study the protein structure and expres...
Supported by the National Natural Science Foundation of China(Nos.30470405and30570864).
Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz.In the present study,we found that dictamine is able to stimulate the chloride transport activity of wild-type and ΔF508 mutant CFTR.The a...
Supported by the National Natural Science Foundation of China(Nos30470405 and 30670477);National Natural ScienceFund for Distinguished Young Scholars(No30325011);Distinguished Young Scholars Fund of Jilin Province(No20030112);Excellent Young Tea
An overt phenotype of aquaporin-1 knockout(AQP1 ko) mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density( BMD), bon...
Supported by the National Natural Science Foundation of China for Distinguished Young Scholars (Grant No. 30325011);National Natural Science Foundation of China (Grant Nos. 30470405 and 30670477);Distinguished Young Scholars Fund of Jilin Province (Grant No. 20030112);Excellent Young Teachers Program of Ministry of Education of China
The asparagine-proline-alanine sequences (NPA motifs) are highly conserved in aquaporin water channel family. Crystallographic studies of AQP1 structure demonstrated that the two NPA motifs are in the narrow central c...
The cystic fibrosis transmembrane conductance regulator (CFFR) is a cAMP-activated chloride channel expressed in intestinal exoerine glands, which plays a key role in intestinal fluid secretion. A natural anthraquin...
Molecular cloning of the porcine leukemia inhibitor factor(pLIF) has not been reported. A full-length eDNA encoding pLIF was cloned, expressed and characterized. The full-length porcine LIF cDNA encodes a 202 amino ...