国家自然科学基金(30830044)

作品数：6被引量：23H指数：2
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相关作者：曹帅王韵赵志奇陈梦玲张玉秋更多>>
相关机构：北京大学复旦大学常熟理工学院更多>>
相关期刊：《生命科学》《Neuroscience Bulletin》《生理学报》更多>>
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蛋白激酶与神经系统功能调控被引量：2
《生命科学》2015年第3期306-315,共10页曹帅 王韵 
国家自然科学基金杰出青年基金项目(30925015);国家自然科学基金重点项目(30830044);国家自然科学中加合作基金项目(91332119);国家重点基础研究发展计划(“973”项目)(2014CB542204)
翻译后的磷酸化修饰是蛋白质结构和功能的重要调节方式。催化蛋白质磷酸化过程的蛋白激酶广泛参与神经发育、感觉、学习记忆、情绪与认知等生理过程及神经退行性疾病、慢性疼痛及精神疾病等病理生理过程,是生命科学领域的研究热点。现...
关键词：神经系统 蛋白激酶 CDK5 PKD1 LIMK 
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice被引量：1
《Neuroscience Bulletin》2014年第6期1025-1035,共11页Ying Zhang Ning Wang Ping Su Jie Lu Yun Wang 
supported by grants from the National Natural Science Foundation of China (91332119,81161120497,30925015,30830044,31371143,30900582 and 81221002);the National Basic Research Development Program from the Ministry of Science and Technology of China (2014CB542204)
Dopamine D1 receptors（D1Rs） play a key role in cocaine addiction, and multiple protein kinases such as GRKs, PKA, and PKC are involved in their phosphorylation. Recently, we reported that protein kinase D1 phosphory...
关键词：protein kinase D1 dopamine D1 receptor PHOSPHORYLATION COCAINE ADDICTION conditioned place preference locomotor activity 
Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system被引量：4
《Neuroscience Bulletin》2014年第3期497-504,共8页Gang Li Yun Wang 
supported by the National Natural Science Foundation of China (81161120497, 30925015, 30830044, 30900582, and 81221002);the National Basic Research Development Program (973 Program) of China (2014CB542204)
Protein kinase D （PKD） is an evolutionarily-conserved family of protein kinases. It has structural, regulatory, and enzymatic properties quite different from the PKC family. Many stimuli induce PKD signaling, includ...
关键词：PKD neuronal polarity pain modulation NEUROPROTECTION learning 
水通道蛋白4敲除对吗啡戒断小鼠脊髓PKCα、PKCγ及c-Fos的影响(英文)
《生理学报》2012年第4期365-371,共7页陈梦玲 鲍峰 张玉秋 赵志奇 
supported by the National Basic Research Development Program of China (No. 2006CB500807,2007CB512303 and 2007CB512502);the National Natural Science Foundation of China (No. 30830044)
水通道蛋白4(aquaporin 4, AQP4)基因敲除小鼠的阿片类躯体依赖症状减轻,但其具体机制至今仍不清楚。本实验通过免疫印迹法观察了与神经元敏化、阿片依赖密切相关的三个重要因子——蛋白激酶C (protein kinase C, PKC)亚型α、γ以及c-...
关键词：水通道蛋白4 C-FOS蛋白 小鼠 吗啡戒断 脊髓 蛋白激酶C 
Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity被引量：2
《Neuroscience Bulletin》2012年第2期182-192,共11页Hai-Jing Chen Wei-Yan Xie Fang Hu Ying Zhang Jun Wang Yun Wang 
supported by grants from the National Natural Science Foundation of China (30830044, 30925015, 30800330, and 81161120497);Beijing Natural Science Foundation (7092061);Specialized Research Fund for Doctoral Program of Higher Education Grants, China (200800011028 and 20060001121)
Objective Our previous study identified Threonine 161 （Thr-161）, located in the second intracellular loop of the 6-opioid receptor （DOR）, as the only consensus phosphorylation Cdte for cyclin-dqpendent kinase 5 （...
关键词：inflammatory hypersensitivity cyclin-dependent kinase 5 6-opioid receptor morphine tolerance 
Activation of glycine site and GluN2B subunit of NMDA receptors is necessary for ERK/CREB signaling cascade in rostral anterior cingulate cortex in rats:Implications for affective pain被引量：15
《Neuroscience Bulletin》2012年第1期77-87,共11页Hong Cao Wen-Hua Ren Mu-Ye Zhu Zhi-Qi Zhao Yu-Qiu Zhang 
supported by the National Natural Science Foundation of China (30900444,31070973,30870835,31121061 and 30830044)
Objective The rostral anterior cingulate cortex （rACC） is implicated in processing the emotional component of pain. N-methyl-D-aspartate receptors （NMDARs） are highly expressed in the rACC and mediate painrelated ...
关键词：N-methyl-D-aspartate receptor glycine site GIuN2B D-SERINE extracellular regulated kinase/cAMP-response element-binding protein signaling pathway rostral anterior cingulate cortex 
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